Bulletin Index 1963-2013
Bull Soc Sci Med Grand Duche Luxemb. 2013;(2):63-8.
Multidisciplinary management of a gastric metastasis of uveal melanoma presenting 12 years after enucleation.
Sofos S, Azagra JS, Arru L, Ries F, Leider P, Weber J, Goergen M.
PMID: 24437076 [PubMed – in process]
2. Bull Soc Sci Med Grand Duche Luxemb. 2013;(2):51-62.
The reduction of stroke risk, risk of myocardial infarction and death by healthy diet and physical activity.
Droste DW, Keipes M.
There is no doubt that a healthy diet and regular physical activity improve risk factors for cerebro-cardio-vascular disease and death. However, there is less evidence from prospective randomised controlled trials that they also reduce the actual risk of stroke, myocardial infarction and death. The only evidence from randomised controlled trials is, that a mediterranean diet with nuts and/or native olive oil considerably reduces stroke risk by 47% respectively 31%,however not the risk of myocardial infarction and death. A low-fat diet, a low-salt diet, and the addition of omega-3 fatty acids have no influence. In case of severe obesity with a BMI of > 34-38 kg/m2, weight reduction is the priority, if necessary by means of bariatric surgery. In longitudinal studies mortality (-29%), stroke (-34%), and myocardial infarction (-29%) could thus be reduced.
Regular physical activity, whether endurance or more intense activity, leads to weight loss and improved vascular risk factors. An independent impact on stroke, myocardial infarction and mortality has not yet been demonstrated in prospective studies (double-blinding being impossible). Nevertheless, several epidemiological meta-analyses with observation durations of 4 to 28 years using data of up to 880 000 persons, indicate that there is a 2-3 fold risk reduction of cerebro-cardio-vascular death and global mortality in people with regular physical activity versus sedentary behaviour.
PMID: 24437075 [PubMed – in process]
3. Bull Soc Sci Med Grand Duche Luxemb. 2013;(2):25-32.
Management of acute diverticulitis in a tertiary care institution.
De Magistris L, Arru L, De Blasi V, Poulain V, Lens V, Mertens
L, Goergen M, Azagra JS.
BACKGROUND: Diverticular disease of the left colon is a common disease, mainly in the population over 50 years of age. The surgical management of acute diverticulitis is remains controversial, especially in severe forms.
OBJECTIVE: This study aimed to evaluate the results of laparoscopic surgery for diverticular disease in a tertiary care institution with a specialist interest in minimally invasive surgery.
DESIGN: All patients who had elective laparoscopic sigmoidectomy for diverticulitis within eight years at University Hospital of Luxembourg were selected from a retrospective database to evaluate laparoscopic benefit in moderate and severe disease.
RESULTS: A total of 155 patients were divided in two groups: Moderate Acute Diverticulitis (MAD) and Severe Acute Diverticulitis (SAD) respectively. The short-term outcomes, after laparoscopic sigmoidectomy, were evaluated. There were not important differences between two groups.
CONCLUSIONS: The laparoscopic management of diverticular disease after moderate and severe crisis gives same benefits and short-term outcomes are similar. Elective Laparoscopic surgery is actually the standard of care for moderate and severe diverticular disease in our institution.
PMID: 24437073 [PubMed – in process]
4. Bull Soc Sci Med Grand Duche Luxemb. 2013;(2):7-24.
Defence mechanisms and coping strategies in men and women: a comparative and structural study based on the artistic production of people suffering from a break-up of their life project.
Schiltz L, Ciccarello A, Ricci-Boyer L, Schiltz J.
A comparative study of men and women suffering from a break-up of their life project allowed us examining the typically female and male manners to cope with trauma, anxiety, guilt, depression and internal destructivity. In a first stage, an exploratory study was focussed on 206 subjects, belonging to several clinical subgroups: people living in great precarity and long-term unemployed people, asylum seekers and refugees, drug addicts, prisoners and people coming out of prison. Secondly, arts therapeutic sessions were proposed with the aim of helping the participants finding an outlet to their situation. The artistic production (drawings and stories induced by music) was analysed with the help of original rating scales, constructed in a phenomenological and structural perspective. We will present a synthesis of our qualitative observations, as well as some results of typological and structural studies, computed with the help of non parametric statistical procedures on the data of N = 93 participants. The results allow us pointing to gender differences and defining typically male and female coping styles. Differential indications for psychotherapy can be extracted from these analyses.
PMID: 24437072 [PubMed – in process]
Bull Soc Sci Med Grand Duche Luxemb. 2013;(1):48-71.
Using arts therapies in psycho-oncology: evaluation of an exploratory study implemented in an out-patient setting].
Schiltz L, Zimoch A.
According to the state-of-the-art in health psychology and psycho-oncology, a cancerous disease, as well as the accompanying medical treatments, is a source of intense emotional stress. As feelings of insecurity and anxiety are likely to induce negative effects on immune defences, those effects may overlap with the cancerous disease and complicate its evolution. As arts therapies tend to favour the imaginary and symbolic elaboration of the tensions of daily life, as well as the re appropriation of one’s body and personal history, different artistic
mediations may occupy an important function in the psychological follow-up of the patient. Following an exploratory study in a hospital, we carried out an action-research in an out-patient setting during six moths. The arts therapeutic treatment comprehended alternatively drawing and writing sessions while listening to music, opening tracks for a thorough verbal elaboration. The evaluation was based on psychometric scales (HADS and MDBF), rating scales for the pictorial and literary production and a semi-structured interview. According to the results of
the quantitative analyses, based on non parametric statistical procedures for small groups and non metric data, as well as to the qualitative content analyses, arts therapies could become a valuable treating measure within a multidisciplinary bio-psycho-social approach.
Bull Soc Sci Med Grand Duche Luxemb. 2013;(1):40-6.
Giant melanoma of the scalp: Case report.
Calteux N, Berchem G, Schmid N, Nebendahl J, Fischer G.
We present a case of giant melanoma of the scalp observed in our department. It is a rare but very aggressive pathology which is generally treated by radical surgery. We emphasize early diagnosis because a large extension of the tumor can lead to the need of a very extensive surgical resection. Prognosis is very severe despite adjuvant medical treatments.
Bull Soc Sci Med Grand Duche Luxemb. 2013;(1):28-38.
Lifestyle counseling in patients with carotid arteriosclerosis from Luxemburg should focus more on the reduction of sugar, sodium and saturated fat consumption.
Droste DW, Iliescu C, Vaillant M, Gantenbein M, De Bremaeker N, Lieunard C, Velez T, Meyer M, Guth T, Kuemmerle A, Chioti A.
BACKGROUND: Healthy diet and physical activity improve risk factors for
cerebrovascular disease. It is unclear whether patients with carotid artery disease from Luxemburg meet common guideline criteria and whether systematic counseling has a sustained effect.
METHODS: We assessed anthropometric data, eating habits and physical activity habits in 53 patients with carotid atherosclerosis at baseline, after 4 and 20 weeks, and advised them five times for 30 min to follow a modified Mediterranean diet and to perform moderate physical exercise at least during 30 min/day.
RESULTS: The patients had a mildly increased BMI (mean 27.6, recommended below 25), they already ate enough vegetables and fruits (mean 485 g daily, recommended at least 400 g), they ate too much sugar (mean 74 g daily) and sodium (mean 2710 mg daily, recommended less than 1500), they consumed 13% of calories from saturated fatty acids (recommended less than 10%), and they already moved sufficiently (62 min daily of moderate and intense physical activity, recommended at least 30 min of moderate physical activity). Lifestyle counseling had a sustained effect on weight, reduction of global caloric intake, carbohydrate and cholesterol intake and on an increase in consumption of poly-unsaturated fatty
acids, vegetables and fibres. There was no sustained effect on the consumption of sugar, sodium, and saturated fat.
CONCLUSIONS: The reduction of sugar, sodium and saturated fat consumption should be stressed more in counselling of this patient group.
Bull Soc Sci Med Grand Duche Luxemb. 2013;(1):20-6.
A few reflections and definitions on the subject of embryonic research.
Tissue regeneration by embryonic stem cells (ESC) opens new applications for cellular therapy. ECS are used in endocrinology, rheumatology, cardiology, orthopaedics, dermatology and neurology. They come from supernumerary embryos given by their progenitors to science. The moral embryo status is the conflicting point and a hotly debated question. No ethical committee has given any valuable definition. Some countries have set time limits governing research with embryos, while others consider ECS as more akin to things or living beings such as animals.
Bull Soc Sci Med Grand Duche Luxemb. 2013;(1):6-19.
Prostate cancer in Luxembourg from 1982 to 2006. Incidence and mortality.
Survival of a hospital cohort.
Lamy S, Wilmart JF, Hein T, Scheiden R, Capesius C.
Prostate cancer incidence has tripled in Luxembourg as in many other western countries. From 1982 to 2006, new cases increased from 80 to 309 per year, while the incidence (world stand.pop.) rose from 29.5 to 85 per 100 000 men. Since 1991 prostate cancer is the most frequent male cancer in Luxembourg, exceeding colo-rectal, lung and stomach cancer. Prostate cancer deaths have diminished from 64 in 1982 to 45 in 2006. This represents less than 10% of male cancer related deaths; it represents the third most frequent cancer death, behind lung and colo-rectal cancers. Annual mortality rate has decreased from 29 to 10 per 100
000 men during the same period, this difference between incidence and mortality is explained on the one hand by the widespread use of PSA since the 1990’s and on the other hand by a better local control as well as a multidisciplinary approach of advanced disease. The increase of the incidence is particularly important in the 60 to 70 age group, while for men older than 70, the peak incidence was reached in 2002. A lowering of the age at diagnosis is confirmed by the 5-year age group analysis. The hospital cohort consists of 628 patients from the urological department of the Centre Hospitalier de Luxembourg diagnosed with prostate cancer between 1st January 1982 and 31st December 2006; follow-up ended 31st December 2011. During this period, age at diagnosis decreased from 71.5 to 68.9 years whereas the proportion of localized clinical stages increased from 44 to 70%. Median PSA dropped from 14.5 to 9 ng/ml. Furthermore the analysis of cancer specific mortality confirms the negative effects of an advanced clinical stage (10-year survival: 90% for localized disease, 60% for advanced disease) or a high PSA level at diagnosis (10-year survival: 97% if PSA < 4 ng/nl, 94% if 4 < PSA < 10, and 72% if PSA > 10 ng/ml), as well as a poor differentiation (60% 10-year survival compared to 90% for differentiated tumors). Kaplan-Meier curves show that long term surveillance is necessary as even tumors with a good initial prognosis may relapse after 10-12 years.
Bull Soc Sci Med Grand Duche Luxemb. 2012;(2):49-62.
Investigation of an excess of Salmonella enteritidis phage type 14b and MLVA type 4-7-3-13-10-2-2 in Luxembourg, Belgium and Germany during 2010.
Mossong J, Ragimbeau C, Schuh J, Weicherding P, Peetso R, Wildemauwe C,
Imberechts H, Rabsch W, Bertrand S.
We investigated an increase of human cases of Salmonella Enteritidis occurring from August until November 2010 in Belgium, Luxembourg and Germany involving an estimated three hundred laboratory confirmed cases. Molecular typing indicated that the increase in Luxembourg and Belgium was due a particular strain having phage type 14b, MLVA pattern 4-7-3-13-10-2-2 and fully susceptible to the Enternet panel of antibiotics. MLVA and phage typing were found to have similar discriminatory power on a collection of 40 Belgian and Luxembourg strains isolated during 2010. Epidemiological investigations in Luxembourg suggested eggs as a possible source for some cases, although supermarket eggs tested were negative. No other EU countries observed a substantial increase of cases, although three smaller outbreaks in Germany were also due to a strain with the same phage type and MLVA pattern. In 2010 the EU directive banning battery cages came into force in Germany followed by a dioxin food scare incident. Given that the EU Laying Hens Directive will come into force across all Member States in 2012, a closer monitoring of Salmonella contamination of imported eggs at retail and wholesale level is recommended.
Bull Soc Sci Med Grand Duche Luxemb. 2012;(2):37-48.
Transpatellar access for intramedullary stabilisation of the tibia.
Gerich T, Backes F, Pape D, Seil R.
Postoperative deformities of the knee and sequaelae after intraarticular surgery can interfere with a standard parapetallar approach for intramedullary stabilisation of the tibia. Even the suprapatellar approach can be rendered impossible. For these rare indications we describe the patella osteotomy and transpatellar approach.
Bull Soc Sci Med Grand Duche Luxemb. 2012;(2):25-35.
Risk factors and disease prevalence in 3331 personal check-ups performed in preventive medicine between 2006 and 2011. cross-sectional and follow-up study.
Keipes M, Bellucci A, Hansen E.
INTRODUCTION: The present data results from a retrospective analysis of 3331 check-ups made in the preventive medicine department of the “ZithaKlinik”, named “ZithaGesondheetsZentrum”. These check-ups are done for the employee’s of several firm’s and institutions. According to gender and age, several tests and examinations are performed and the results are given to the person’s general practitioner or another doctor of his choice. We will present a global synthesis of all the results but also a follow-up study of persons having performed 2 check-ups or more over a 5-year period.
POPULATION: In the cross-sectional part, the analysis is done on 3331 individual check-ups (1447 woman, 1884 men). The average age is 50.3 years +/- 11.4. In the follow-up study, 478 persons (191 women, 287 men) had at least 2 (maximum 5) check-ups in the 5-year period of our observation. Initial age was 54.1 +/- 10.9 years for woman and 51.4 +/- 11.4 for men, respectively 56.4 +/- 10.9 and 53.7+/- 11.2 at their last check-up.
RESULTS: An alarming number of persons present with a weight or obesity problem (according to age ranging from 22.0% overweight and 7.3% obese from 18-29 years, respectively 37.5% and 11.3% from 30-49 years, finally 44.0% and 20.6% in the range 50-69 years). Associated risk factors and pathologies (Hypertension, Dyslipidemia, NASH, diabetes type 2 and complete metabolic syndromes) are extremely frequent and getting more so with growing age. Furthermore, physical activity is insufficient in grossly 2/3 of the studied population. The only positive point is a tendency of decreasing tobacco use in all age groups. The follow-up study is frustrating because most of the examined criteria get worse in-between check-ups instead of getting better with changes in lifestyle in an informed population.
CONCLUSIONS: Asymptomatic diseases or risk factors for non-communicable diseases are extremely frequent in the population examined. The follow-up data shows that huge parts of this group are not sufficiently conscientious of their problems to act up and change their life-style or seek adapted pharmacological prevention.
Absolute number of risk factors (prevalence) or pathologies rise evidently with age but incidence (newly discovered pathologies after a first, second or a record of 21 check-ups with our services) rises less. Life-style changes are rare or insufficient to change the pathological value back to normal or therapeutically range. Even with several biases (retrospective design, selection bias, …) our study puts similar problems forward in the population as ORISCAV. The astonishing (better than national records) results in tobacco use is probably due to a selection of more health-oriented patients and of a higher socio-educative-economic level. Alcohol abuse was very low but probably due to inadequate screening methods. A better health promotion advocating healthier living must be associated with better communication and new motivational tools.
Therapeutical education for patients with chronic non-communicable diseases will be the challenge of the near future as their prevalences increase due to ageing of the population and worse individual lifestyles. In this task, efforts must be made on the personal level (health-team with the individual patient) but also on the national level (legal frame work for patient education by multi-professional teams as they exist already in neighbor states).
Bull Soc Sci Med Grand Duche Luxemb. 2012;(2):15-24.
DTI of the visual pathway in cerebral lesions.
Hana A, Husch A, Hana A, Boecher-Schwarz H, Hertel F.
Diffusion tensor imaging (DTI) can be used to localise the visual pathway (VP). In the service of the neurosurgery we have been working since the beginning of this year to develop a protocol which is suitable for the every day clinical routine to show the tracts of the white matter. Many lesions of the brain concern the white matter. Up to date it is still difficult to portray the visual pathway. Many centers all around the world are actually trying to localize the visual pathway, yet it is still used for the research. The application of the DTI-data for surgical interventions remains still a rarity. We believe that using this technique it would reduce the intraoperative risk and improve the postoperative outcome. From the beginning of this year we have been able to localize the visual pathway in 14 patients with different illnesses and we performed also postoperative controls. Using this new technique we were able to minimize the intraoperative risk in our patients.
Bull Soc Sci Med Grand Duche Luxemb. 2012;(2):7-14.
Taste preference and psychopathology.
Aguayo GA, Vaillant MT, Arendt C, Bachim S, Pull CB.
OBJECTIVE: Excessive food intake has been linked to many factors including taste preference and the presence of psychopathology. The purpose of this study was to investigate the association between sweet and salty taste preference and psychopathology in patients with severe obesity.
METHODS: A consecutive series of patients applying for bariatric surgery was recruited for the study. Taste preference was self-reported. Psychopathology was assessed using the revised version of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). 190 patients were included in the study.
RESULTS: In comparison with patients who had salty taste preference, patients with sweet taste preference had significantly higher elevations on the depression (OD: 4.090, p = 0.010) and the hysteria (OD: 2.951, p = 0.026) clinical scales of the MMPI-2.
CONCLUSION: The results suggest the presence of an association between taste preference and psychopathology. The findings may be of interest for clinicians who are involved in the treatment of obesity. In particular, they may wish to pay increased attention to patients with sweet taste preference or who have a strong attraction for both sweet and salty foods, in order to detect psychopathology and to adapt the treatment.
Bull Soc Sci Med Grand Duche Luxemb. 2012;(1):60-70.
Impact of initial intervention on long-term neurological recovery after cardiac arrest: data from the Luxembourg “North Pole” cohort.
Stammet P, Collas D, Werer C, Muenster L, Clarens C, Wagner D.
BACKGROUND: Prognosis after cardiac arrest is variable and difficult to predict. Early prognostic markers would facilitate the care of these patients.
AIMS: Therefore, we evaluated the impact of initial interventions after resuscitation on neurological outcome at 6 months.
MATERIAL AND METHODS: We conducted a retrospective analysis of the patient charts from consecutive cardiac arrest patients admitted to our intensive care unit and treated with induced hypothermia.
RESULTS: Over a 3-year period, 90 patients were included in our study. Sixty-four percent of the patients had bystander cardio-pulmonary resuscitation. An automated external defibrillator (AED) was used in 19% of the patients and the mean time to first defibrillation was 11 +/- 8.9 minutes. Patients being resuscitated and defibrillated by bystanders did better than those who had CPR only and far better than those patients in whom no rescue measures where attempted at all (73% vs. 56% vs. 32% for good neurological outcome, respectively, p= 0.03). Witnessed cardiac arrest was more frequent in patients with a good outcome than in those who collapsed without a witness (91% vs 75%, p = 0.03). In 76% of the patients with good outcome, CPR was performed whereas only 52% benefited from these measures in the bad outcome group (p = 0.01). Although the use of an AED was not significantly different between good and bad outcome groups (26% vs. 11%, p = 0.06), time to first defibrillation was significantly lower in patients with good outcome (8.7 +/- 6.3 vs. 13.3 +/- 11.3 minutes, p = 0.05). In the 17 patients in whom an AED was used, 12 (71%) recovered without major sequelae whereas in the 73 cases where no AED was used, only 34 (47%) had a good outcome (p = 0.06). At 6 months follow-up, 46 (51%) survivors had a good outcome (cerebral performance category 1-2), 5 (6%) survived with severe neurological sequelae or stayed in coma and 39 (43%) died.
CONCLUSIONS: Our local data confirm that early interventions have a major impact on survival of cardiac arrest patients. Efforts should oncentrate on delivering rapid and high quality CPR as well as early defibrillation by AED’s to every patient in cardiac arrest. Besides large scale Basic life support training, the introduction of dispatcher assisted CPR and the implementation and use of public AED’s could considerably help to improve outcome in these patients.
Bull Soc Sci Med Grand Duche Luxemb. 2012;(1):50-9.
The Luxembourg Society for Sports Medicine (SLM) after 60 years.
This review will mainly focus the last 10 years of the society’s history because several important changes occurred during this relatively short period. The most important was the creation of the first clinical sports medicine department in Luxembourg in 2004. This modern new infrastructure was made possible by the recruitment of 2 highly competent sports physicians, the excellent collaboration of the governing board of the Centre Hospitalier de Luxembourg (CHL) and the support of the sports minister. In 2008 the new department received the label “Medical Olympic Centre of Luxembourg”. One year later a Research Lab of Sports
Medicine (CRP-Santé) completed the new concept. Thus within 4 years the structure of Luxembourgish sports medicine was completely rearranged and includes today orthopaedic surgery and traumatology, functional rehabilitation, sports cardiology, exercise physiology, physiotherapy and specific sports medicine research. An important new challenge of the SLMS will be to integrate the external sports physicians into this new infrastructure. Another ongoing mission of the SLMS will be the education and training of new young sports medicine specialists. Here the new department could play an outstanding role and the SLMS is in close negotiations with the University of Luxembourg, in charge of academic education in Luxembourg. A recruitment of new young sports physicians is necessary to perpetuate the routine sports medicine exams in the 15 regional centers in Luxembourg, where such an exam is mandatory in order to get an official sports licence. Since 2010 an ECG exam has been added for all new licence candidates, according to the recent recommendations of the scientific societies. New young sports physicians will also be needed to assure the medical attendance of the different national teams of Luxembourg. Until 1985 these activities were confined only to the Olympic teams every 4 years, but since the implementation of the Games of the Small European Countries in 1985, where rather big teams represent Luxembourg every two years, this mission has become more important. The history of the SLMS reflects the development both of sports and sports medicine during the last 60 years. At the beginning of the 21.century sports medicine is well settled in the Grand-duchy of Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 2012;(1):43-9.
The OPTIMISE study (Optimal Type 2 Diabetes Management Including Benchmarking and Standard Treatment). Results for Luxembourg.
Michel G; OPTIMISE.
Collaborators: Anton P, Cescutti E, Chidiac T, Daman F, Fischer G, Godart A, Heftrich R, Koppes J, Kuntz A, Marin L, Muller-Ganser M, Nuss M, Oms P, Reuter P, Richarts N, Santana S, Schmit D, Schmit R, Theis F, Thiry D, Trierweiler P, Waldbillig M, Weber C, Weis A.
The OPTIMISE study (NCT00681850) has been run in six European countries, including Luxembourg, to prospectively assess the effect of benchmarking on the quality of primary care in patients with type 2 diabetes, using major modifiable vascular risk factors as critical quality indicators. Primary care centers treating type 2 diabetic patients were randomized to give standard care (control group) or standard care with feedback benchmarked against other centers in each country (benchmarking group). Primary endpoint was percentage of patients in the benchmarking group achieving pre-set targets of the critical quality indicators: glycated hemoglobin (HbAlc), systolic blood pressure (SBP) and low-density lipoprotein (LDL) cholesterol after 12 months follow-up. In Luxembourg, in the benchmarking group, more patients achieved target for SBP (40.2% vs. 20%) and for LDL-cholesterol (50.4% vs. 44.2%). 12.9% of patients in the benchmarking group met all three targets compared with patients in the control group (8.3%). In this randomized, controlled study, benchmarking was shown to be an effective tool for improving critical quality indicator targets, which are the principal modifiable vascular risk factors in diabetes type 2.
Bull Soc Sci Med Grand Duche Luxemb. 2012;(1):32-42.
The dependence level of the elderly person influences the risk of infection.
Wiedenkeller B, Modert F, Karleskind I.
OBJECTIVE: Assess the impact of the reduction or loss of autonomy of the elderly in the nosocomial infection risk.
METHOD: Using Karnosfsky scale (KPS). This study involved 163 patients aged 65 and over hospitalized for medical reasons. Data collection: KPS index, body mass index, Index Norton, bladder’s drainage system at the entrance and during hospitalization, colonization of resistant bacteria (BMR) at entry and during hospitalization, antibiotic use at entry and during hospitalization, infection at entry and during hospitalization.
RESULTS: There is a statistically significant relationship between the degree of autonomy and the index of risk of pressure ulcers (Norton), between the degree of autonomy and the use of bladder’s drainage system, between the degree of autonomy and risk acquisition of BMR, between the degree of autonomy and the nosocomial infection risk.
CONCLUSION: The level of dependence increases the risk of infection nosocomial: loss of autonomy is a risk factor for infection. The evaluation of the degree o autonomy of elderly patients at entry and at regular intervals is essential in ou view a policy of reducing nosocomial infections.
Bull Soc Sci Med Grand Duche Luxemb. 2012;(1):21-31.
Can one authorize oocyte donation in the Grand Duchy of Luxembourg?.
In the case of early ovary extinction, the only way to have a child is either adoption or egg/embryo reception by donation. To day, egg donation is prohibited in Luxembourg by ministerial decision in 2003. Germ cell donation is part of artificial reproductive therapy. Oocyte donation, in particular, needs to be done by IVF treatment, which makes it more complicated then sperm donation What makes it more difficult is the fact that there are no oocyte bank yet. Today, prohibition encourages procreative tourism what only wealthy people can afford.
Although donation programs are well established many questions arise about egg donation such as refunds, divulging information, women’s age limit, health insurance participation.
20. Bull Soc Sci Med Grand Duche Luxemb. 2012;(1):7-20.
The general practitioner faced with memory problems in the aged patient in Luxembourg: a study of the management employed, the experience of the physicians and the perception of the specific treatment.
Gondoin C, Lévy F, Tirmarche D.
Memory impairments are common in elderly. General practitioners are in first line to detect and manage these troubles, for which many countries published recommendations. For Alzheimer disease there are currently four treatments, none of which is healing. Some countries limited the first prescription of those medicines to specialists whereas in Luxembourg, every practitioner is allowed to prescribe them, but has to ask health insurance first. Consequently, it is important that general practitioners know what to do. The aim of our paper is to study the management done by the general practitioners in Luxembourg, the way they feel about it and the way they see the specific medicines for Alzheimer disease. Therefore, we have sent a questionnaire to every general practitioner in Luxembourg. We found that 87% of the practitioners realize at least one cognitive impairment test. More than half of them check for depression and 22.6% also add an autonomy assessment scale, even though all these tests are done by the dependence insurance. The involvement of general practitioners in the diagnosis of dementia is important as more than half of them have a statistically adequate number of demented patients. About two third of the practitioners do systematically start a specific medicine for Alzheimer disease. The management of cognitive impairment is difficult for general practitioners of Luxembourg, particularly the disclosure of diagnosis and management of behavioural and psychological symptoms.
Bull Soc Sci Med Grand Duche Luxemb. 2011;(2):57-70.
A clinical, radiological and computational analysis of the thrust plate
prosthesis in young patients.
Gerich TG, Wilmes P, Nackenhorst U, Gösling T, Ziefle M, Krettek C.
BACKGROUND AND PURPOSE: A thrust plate prosthesis can be used as an alternative to a conventional stem prosthesis, preserving the diaphyseal bone stock. Recent findings however predict a higher rate of aseptic loosening than with intramedullary devices. The purpose of our investigation was to compare the clinical outcome and radiological findings with a finite element analysis of bone remodeling. The hypothesis was that aseptic loosening after thrust plate prosthesis of the hip is inherent to the design.
METHODS: From 1997 to 2001, 58 thrust plates were implanted in 52 patients. Average age at the time of surgery was 40.9 years. Ninety four percent returned for follow up at an average of 26 months. A finite element model of the thrust plate within the femur was developed and stress shielding as well as bone remodeling were analyzed.
RESULTS: A total of 4 patients required revision surgery (6.9%). Data from the finite element analysis revealed an inherent failure mechanism to the implant, facilitating stress shielding and loosening.
INTERPRETATION: Lacking the ideal total hip prosthesis in young patients, the thrust plate can still be regarded as a feasible implant. However, surgeons and patients should be aware of possible mechanical problems regarding the design of the thrust plate. There is evidence that thrust plate prostheses are prone to early aseptic loosening. Clinical and radiological observations are in agreement with the results from the numerical simulations. Stress concentrations computed at the leash are interpreted as an explanation for leash pain. The authors regard computational methods as an aid to improve existing prosthesis design and future developments.
Bull Soc Sci Med Grand Duche Luxemb. 2011;(2):43-55.
Lung cancer statistics in Luxembourg from 1981 to 2008.
Thill PG, Goswami P, Berchem G, Domon B.
Lung cancer is the leading cause of cancer-related death in the world and in Luxembourg. As a part of “The health science initiative focused on personalized medicine”, Luxembourg aims to participate by developing diagnostics to improve the detection and treatment of lung cancer. In line with this objective, this study made a review of evolution of lung cancer in Luxembourg from 1981 to 2008 and compared this statistics to the situation in the Nordic countries, Europe in general and the World. Incidence data of the national morphological tumour registry and mortality data of the service of statistics of the national ministry of health is depicted in charts with trend lines, in the framework of a statistical evaluation of relevant parameters. The data indicate that while male lung cancer incidence decreased in Luxembourg, the incidence in women and its mortality have doubled over the 28-year span considered. Notwithstanding this increase, the female lung cancer incidence and mortality remain low compared to the Nordic countries and Europe. Interestingly, the study also potentially suggests that the lung cancer pattern follows the smoking pattern in incidence and mortality.
Bull Soc Sci Med Grand Duche Luxemb. 2011;(2):35-42.
7-year results of cell therapy in patients with severe ischemic cardiomyopathy.
Ekosso L, Delagardelle C, Berchem G, Beissel J, Wagner DR.
BACKGROUND: Intracoronary infusion of autologous bone marrow cells (CTX) has been shown to improve myocardial function in post infarct patients and in patients with chronic ischemic cardiomyopathy. Long term results of CTX are unknown.
METHODS AND RESULTS: In this small pilot study, eleven patients with chronic ischemic cardiomyopathy and ejection fraction (EF) of 19 +/- 1% were treated with CTX and followed for 7 years. Four patients died during follow-up, all because of progressive heart failure. All patients received an implantable cardioverter defibrillator (ICD) during the course of the study but only 1 patients developed ventricular tachycardia after CTX. One patient received resynchronization therapy. The overall clinical benefit of CTX was modest (NYHA 3.0 +/- 0.1 pre and
2.5 +/- 0.2 post CTX, p= 0.06). CTX was not associated with reverse remodeling.
However, left ventricular EF (19 +/- 1% pre and 18 +/- 6% post) and left
ventricular end-diastolic volumes (289 +/- 71 ml pre and 294 +/- 123 ml post) remained remarkably stable over 7-year follow-up in the survivors of this very sick population.
CONCLUSIONS: During 7-year follow-up, CTX was associated with stabilization of EF and ventricular volumes but without significant clinical benefit or evidence of reverse remodeling.
26. Bull Soc Sci Med Grand Duche Luxemb. 2011;(2):25-33.
Actual state and prospects of acute stroke treatment in the Grand-Duchy of Luxemburg].
Droste DW, Metz R.
Stroke is a neurological emergency condition that warrants immediate
hospitalisation on a stroke unit, where a dedicated team offers state-of-the-art diagnostic and therapeutic measures. Stroke units have shown to reduce mortality and handicap especially if thrombolysis is possible. A critical mass of stroke patients with standardised, simplified and automated processes is required to achieve good results. Stroke teams are no alternative to a stroke unit as a geographic unit. A turnover of less than 200-250 strokes per year is associated with a worse patient outcome and the treatment effect of a stroke unit may be abolished. The situation in Luxembourg offers the possibility to create units of this size and performance if all the concerned physicians and hospitals, health insurance and health administration join their efforts.
Bull Soc Sci Med Grand Duche Luxemb. 2011;(2):7-24.
Influence of obesity-susceptibility loci (MC4R and INSIG2) on the outcome of weight loss and amelioration of co-morbidity in obese patients treated by a gastric-bypass.
Goergen M, Manzoni D, De Blasi V, Fabiano P, Poulain V, De Magistris L, Simonelli, V, Dahan K, Azagra JS.
BACKGROUND: Genome-wide association and linkage studies have identified multiple susceptibility loci for obesity.
OBJECTIVE: We hypothesized that such loci may affect weight loss and comorbidity amelioration outcomes following a gastric-bypass.
DESIGN: A total of 200 obese patients who underwent a gastric bypass surgery were genotyped for single-nucleotide polymorphisms (SNPs) in insulin induced gene 2 (INSIG2) and melanocortin 4 receptor (MC4R) obesity genes.
RESULTS: After a follow-up of 18 month, the patients (192) data of weight excess loss (72%) and co-morbidities (Hypertension -62- and Diabetes -39-) were analyzed and compared. 26 Patients with SNP were found (9 MC4R and 17 INSIG2). No significant differences in weight excess loss and amelioration of comorbidities were revealed.
CONCLUSIONS: The data suggest no influence of weight excess loss and amelioration of co-morbidities after gastric-bypass by genetic susceptibility.
Bull Soc Sci Med Grand Duche Luxemb. 2011;(1):7-17.
25 years of organized ambulatory heart sport in Luxembourg. The development of a sustained rehabilitation model.
Delagardelle C, Feiereisen P.
After Second World War cardiovascular disease (CVD), especially coronary artery disease (CAD), turned out to be an epidemic in the western countries including the Grand-Duchy of Luxembourg, and accounted for nearly half of all deaths. A lot of strategies, among them treatment by physical activity, were developed to fight this challenge and, fortunately, a mortality regression of about 50 % could be achieved. Nowadays, eastern European countries and, more recently, China and
India face an increasing CVD mortality. During the seventies ambulatory heart sport clubs, then labeled as, “coronary clubs” became very popular in Europe especially in West-Germany. Around 2000 there were more than 6000 heart sports groups in Germany. In 1984 a first group was founded in Luxembourg City (Centre) a, 1991 a second group started in Esch/Alzette (South) and in 2002 a third regional group in Ettelbruck (North) so that, by now, the 3 main public health districts of the Grand-Duchy of Luxembourg can offer regular ambulatory sports activities to almost all concerned cardiac patients in the country. The ambulatory heart sport groups of Luxembourg cooperate in a federated association allowing an integrated logistic organization. Since the beginning nineties cardiac rehabilitation became a field of interest to the university faculties and later of scientific societies, like the American Heart Association (AHA) and the European Society of Cardiology (ESC). New subgroups were founded and guidelines were published and renewed. The movement of ambulatory heart sport groups was more or less neglected in the prevention and rehabilitation activities of the scientific societies. Recently the ESC proposed a new definition of comprehensive CVD prevention and rehabilitation programmes as “coordinated, multifaceted interventions designed to optimize a cardiac patient’s physical, psychological, and social functioning, in addition to stabilizing, slowing, or even reversing the progression of the underlying atherosclerotic processes, thereby reducing morbidity and mortality”. The responsible ESC cardiologists agree with the international community that fighting CVD risk factors is at least as important as the whole arsenal of modern heart surgery and interventional cardiology. The core activity of ambulatory heart sport groups remains physical activity, and nowadays 6 different activities can be offered (one activity each day of the week): exercise lesson, swimming, walking, cycling, Nordic Walking and water gymnastics On the other hand comprehensive prevention programs, especially concerning CVD risk factors are also endorsed by the ambulatory heart sport groups of Luxembourg via regular meetings, conferences, brochures and symposia.
One advantage of the ambulatory heart sport movement in Luxembourg, in contrast to the German model, is the direct financial allowance of the health ministry, which permits a lifelong activity to all the active members. Another advantage is that all the regional groups are directed by clinical cardiologists knowing the patients very closely. One weak point is that only about 5-10% of all potential candidates adhere to the ambulatory heart sport groups but nearly 50% of the active members are practicing for more than 5 years. These regularly active patients are a positive selection of well committed cardiac patients who, most of the time, control CVD risk factors with scrutiny. The ESC has recommended creating so called “Heart Houses” where all the aspects of comprehensive prevention and rehabilitation can be offered. Their main concern is to develop a sustained strategy which is desperately missing for the moment. A lot of the active members of the heart sport groups of Luxembourg achieve such a sustained activity and, therefore, these heart sport groups can be considered as very cost effective models of sustained rehabilitation. After a 25 years activity the ambulatory heart sport movement of Luxemburg has reached the outstanding goal of being a center of sustained rehabilitation. Although such a goal was not really planned during the first 15 years of activity, the stamina of the active members set the movement into this direction.
Bull Soc Sci Med Grand Duche Luxemb. 2011;(1):41-71.
Predictive relevance of clinical scores and inflammatory parameters in secondary peritonitis.
Zügel NP, Kox M, Lichtwark-Aschoff M, Gippner-Steppert C, Jochum M.
HYPOTHESIS: To measure and evaluate clinical scores and various inflammation parameters for providing a better outcome assessment of patients with secondary peritonitis.
DESIGN: Prospective study.
SETTING: ICU of a university and a university affiliated hospital.
PATIENTS: Fifty-six patients with severe secondary peritonitis were enrolled in this study executed within 4 years.
MEASUREMENTS AND MAIN RESULTS: Blood samples were taken preoperatively and 2, 6, 8, 12, 18, 24, 30, 36, 42 and 48 hours post operation, thereafter every 12th hour until day 5 respectively once daily until day 14. Etiology of peritonitis, clinical score systems (APACHE II, MOF and SOFA), and 27 mainly with activity tests or enzyme-immunoassays measurable inflammation parameters were simultaneously analyzed and stratified into lethal outcome (n = 11) or survival (n = 45), respectively. The etiological distribution of peritonitis was identical among both groups. Proportion of intraperitoneal fungi, E. coli, and bacteroids was substantially higher during the primary operation in the group with lethal outcome. With increasing significance initial and follow-up APACHE II, MOF and SOFA scores provided higher values in this group. Various plasma/serum parameters of hemostasis, leukocyte proteolytic system, acute phase reaction, cytokine system, cell adhesion, opsonization, and main organ functions showed significantly different values between both groups at the preoperative stage and/or during observation period I (day 0-4). Logistic regression analysis revealed the SOFA score and neopterin concentration as the combination with the best sensitivity (63.6%) and specificity (93.2%) for predicting the patients’ survival even at the preoperative stage. For the observation period I, the combination of SOFA score and TNF receptor II showed the highest predictive sensitivity (72.7%) and specificity (95.6%).
CONCLUSION: Evaluation of the severity of secondary peritonitis using a scoring system with high prognostic relevance could conceivably result in an earlier and adequate application of intensive care such as hemofiltration, administration of immunoglobulins and serial abdominal lavage to improve successful outcome.
Bull Soc Sci Med Grand Duche Luxemb. 2011;(1):31-40.
Chemokine receptor 5 polymorphism in myocardial infarction patients from
Rodius S, Lambert C, Devaux C, Schmit JC, Devaux Y, Wagner DR.
BACKGROUND: The CC-chemokine receptor 5 (CCR5) is regulating inflammatory
pathways and may thus be implicated in the development and progression of heart failure (HF). A 32 base pair deletion of the ccr5 gene, called CCR5delta32, prevents the expression of CCR5 at the cell surface. We analyzed the association between the CCR5delta32 deletion and the risk and severity of myocardial infarction (MI) in a cohort of patients from Luxembourg.
METHODS: Using TaqMan allelic discrimination assay, we genotyped a total of 1080 patients undergoing coronary angiography. This population contained 3 groups of patients: controls with atypical chest pain, abnormal stress testing but normal coronary angiography (n = 154), patients with angina who underwent uncomplicated primary coronary intervention (n = 230), and patients with acute MI (n = 696). In
MI patients, left ventricular ejection fraction (LVEF) was determined 1-month after MI with echocardiography.
RESULTS: The frequency of the CCR5delta32 deletion was 16.3% in the global population, and was similar between controls, patients with angina and MI patients. The deletion was not associated with variations of plasma levels of creatine phosphokinase and troponin T, nor it was associated with LVEF, New York Heart Association class or 2-year mortality. The frequency of the deletion was comparable between MI patients with LV dysfunction (EF < or = 40%, n = 82) and no
LV dysfunction (EF > 40%, n = 402).
CONCLUSIONS: The frequency of the CCR5delta32 deletion in Luxembourg is similar to that observed in other European countries and is not associated with the risk of developing MI and LV dysfunction.
Bull Soc Sci Med Grand Duche Luxemb. 2011;(1):19-30.
Predicting significant fibrosis in hepatitis C patients in Luxembourg using serological markers.
Mossong J, Bill S, Hawotte K, Gilson G, Knolle U, Weber J, Roskams T, Arendt V.
OBJECTIVE: The aim of our study was to assess the diagnostic performance of various serological markers and scores for predicting significant fibrosis retrospectively in a population of patients referring to our hospital for liver biopsy and chronic hepatitis C.
MATERIALS AND METHODS: Stored serum obtained from 186 patients were tested for a number of biological markers putatively associated with liver fibrosis. Fibrotest and Forns scores were compared with liver fibrosis pathology scored according to the METAVIR system by multiple logistic regression.
RESULTS: The prevalence of significant fibrosis was 44%. Aspartate amino transferase (AST) and gamma-glutamyltransferase (GGT) were most correlated with METAVIR staging, followed by platelet counts and alpha2-macroglobulin. The negative predictive value was 77% and 83% and the positive predictive value was 100% and 84% for the Forns score and the Fibrotest, respectively. In multivariate analysis AST, GGT and alpha2-macroglobulin had independent predictive power.
CONCLUSIONS: The accuracy of serological markers in predicting significant fibrosis is limited, because approximately two thirds of patients lie into an indeterminate “grey zone”. Serological markers might be useful for patients reluctant to undergo liver biopsy but current predictive scoring systems are too inaccurate to replace biopsies in a routine manner.
Bull Soc Sci Med Grand Duche Luxemb. 2010;(2):319-45.
Astrologic and medical manuscript of the 18th Century.
We present a manuscript from the 18th century, an extract taken from the “Great and the Little Albert” attributed to Albertus Magnus. The linguistic variety in the paper is typical for a text composed in Luxembourg. Added to this text are two incantations and a short cartomancy paper.
Bull Soc Sci Med Grand Duche Luxemb. 2010;(2):303-13.
Safety of the patient and the Mammography Program in the Grand Duchy of
Luxembourg: Care of cancers detected by mammography. Retrospective studies.
Wagnon MC, Scharpantgen A, Back C, Hansen-Koenig D.
In Luxemburg, the national breast cancer mammography screening programme has been running for 18 years. The Coordinating Centre treats approximately 17,000 files a year. The Health Directorate, as promoter of the “Programme Mammographie”, is obliged to provide itself with a maximum of guarantees; within the framework of its legal missions, it has to implement all the possible means in order that the whole approach assures minimal adverse effects. The technical quality of the 9 centres is at the level required by the European Guidelines for Quality Assurance in Mammography Screening and Diagnosis, 4th edition. The quality of the readings was already the subject of 2 evaluations of the performance of the readers: the mean accuracy of the first readers to detect cancers is 87%, of the second readers 97%. The mean recall rate for assessment is about 6%. The double reading assures the detection of between 15 and 21% additional cancers, depending on the years. The imaging of diagnostic assessment has been the subject of a retrospective study. Out of 392 cancers, time from assessment to diagnosis was longer then 24 months for 17 women (4%). Examples are described and reasons for negative assessment are listed. The main cause is the multiplicity of the doctors acting in the assessment process, resulting in a default of the examination synthesis and a certain lack of communication and multidisciplinary approach.
More convergence in diagnostic breast assessment and a shortening of delays between screening and diagnosis, are desirable. In conclusion: The evolution towards Specialist Centres for breast cancer care answers an ethical obligation which the initiators of a public health programme have to assume, such as the organization of a high quality breast cancer screening programme.
Bull Soc Sci Med Grand Duche Luxemb. 2010;(2):289-301.
Evaluation and care of patients with type II diabetes regarding recommendations concerning cardiovascular risk factors and adherence to values in general medicine in the Grand Duchy of Luxembourg.
Stein R, Aubart-Schuller M, Vandenberghe H.
AIMS: The objective of this study was to assess the adherence to national guidelines on cardiovascular prevention and target attainment for patients with type 2 diabetes mellitus followed-up in general practice.
METHODS: Non-interventional, cross-sectional survey.
RESULTS: 606 patients have been considered in this analysis. Type 2 diabetes patients remain undertreated with statins (63% treated), even so those with a cardiovascular history (80% treated). Although more patients received antihypertensive treatment (82%) compared to hypolipidemic medication (69%), the proportion of patients attaining targets for total (35%), HDL (65%), and LDL-cholesterol (42%) exceeded far those attaining blood pressure control (13%).
The primary endpoint of reaching the goal for LDL-cholesterol (<100 mg/dL) was attained by 42% of patients, of which only 13% reached the more stringent target of LDL-C <70 mg/dL. About half of the patients attained glycemic control (HbA1c <7%, 49%) and had triglycerides <150 mg/dL (55%).
CONCLUSIONS: The majority of type 2 diabetes patients are treated for hypercholesterolemia and hypertension, although, there is still undertreatment with statins, especially in patients with CV disease. Only 42% of patients were on target for LDL-cholesterol and 13% for blood pressure. Therefore, wider implementation of process and outcome indicators, which proved to be related, and continuous evaluation of their result, is needed.
Bull Soc Sci Med Grand Duche Luxemb. 2010;(2):279-82.
Early decompressive hemicraniectomy in fulminant herpes simplex encephalitis.
Maraite N, Mataigne F, Pieri V, Dang T, Diederich NJ.
Herpes encephalitis can be a life-threatening condition, despite early instauration of acyclovir treatment. In particular patients may succumb to rapidly progressive cerebral oedema. We report a 66-year patient with a Glasgow Coma Score (GCS) of 6 and incipient uncus herniation of the right temporal lobe on the third day. Decompressive hemicraniectomy was immediately performed. The long-term outcome was satisfactory with unassisted gait and a Barthel Index score of 70 after 9 months.
Bull Soc Sci Med Grand Duche Luxemb. 2010;(2):271-8.
Autoimmune lymphoproliferative syndrome (ALPS). Case report and family history.
Ries F, Ferster A, Rieux-Laucat F, Biwer A, Dicato M.
Autoimmune lymphoproliferative syndrome (ALPS) is a rare disease caused by defective lymphocyte apoptosis and is characterized by non-malignant lymphoproliferation, hepatosplenomegaly, autoimmune manifestations and increased risk of both Hodgkin’s and non-Hodgkin’s lymphoma. Most forms of the disease are due to germ line mutations of the FAS gene and manifest during the first years of life with fluctuating lymphadenopathies, hemolysis, immune thrombocytopenia.
During the second decade of life disease manifestations improve spontaneously but autoimmune problems still occur and there is an increased risk of lymphoproliferative malignancy. We describe a typical case of ALPS in a now 44 year old man, followed since the age of 2 for disease manifestations that were unclear at the beginning.
Bull Soc Sci Med Grand Duche Luxemb. 2010;(2):257-70.
Retrospective studies of pregnancies after assisted medical reproduction from 2001-2009 and Central Hospital in Luxembourg (part 2).
Arendt J, Schilling C, Peiffer M, Ginter S, Nahanb AF, Lemosb C, Duboisb M, Thononb F, Jouanb C, Gaspardb O, Larcher ME, Gomez V, Pereira S, Geimer M.
The first chapter analyses the ART methods of the Centre Hospitalier of Luxembourg, in the department of reproductive medicine between 2001 and 2009. The second chapter examines the techniques individually, their influence on pregnancy outcomes, the complications on offsprings and their health. The results coincide with literature in that risks are acceptable as long as good medical and biological conditions are maintained. Multiple pregnancies remain the most frequent complication, particularly once out of IVF. These are analysed separately as well as the pregnancies after egg and semen donation.
40. Bull Soc Sci Med Grand Duche Luxemb. 2010;(2):247-55.
Retrospective study–pregnancy after assisted medical reproduction from 2001 to 2009 at the Central Hospital of Luxembourg (first section).
Arendt J, Schilling C, Peiffer M, Ginter S, Nahan AF, Lemos C, Dubois M, Thonon F, Jouan C, Gaspard O, Larcher ME, Gomez V, Pereira S, Geimer M.
Retrospective study on a nine year ART practice focusing on pregnancy outcomes and multiple pregnancies, their complications, the gestational duration, delivery options, the new born weights and health statements til the age of two. Post ART pregnancies seem to have an increased complication rate; multiple births are more frequent than with spontaneous conception. The first chapter deals with the entire group. The second chapter analyses several sub-groups according to the ART method employed. The results are compared to publications in PubMed and Medline.
42. Bull Soc Sci Med Grand Duche Luxemb. 2010;Spec No 1(1):229-38.
Evaluation in the interest in arts psychotherapy treatment of alcoholics hospitalized for a weaning process–presentation of two clinical examples.
Ricci-Boyer L, Schiltz L, Spitz E.
The aim of our study is to show the relevance of art therapeutic treatment with an alcoholic population met in the weaning department of a general hospital. A current tendency of research in psychology consists in using an integrated quantitative and qualitative methodology. This approach is especially suited to the study of the therapeutic intervention. In arts therapeutic research the investigation of the artistic production and the application of a projective test
(Rotter) may complete the psychometric tools: SVF 78 Stressverarbeitungsfragebogen by Janke W., Erdmann G., Kallus W.; MDBF
Mehrdimensionalen Befindlichkeitsfragebogens by Steyer R., Schwenkmezger P., Notz P., Eid M. The results of the study show the relevance of our art therapeutic treatment. We are going to illustrate the multidimensional reality of the therapeutic process by two clinical examples.
Bull Soc Sci Med Grand Duche Luxemb. 2010;Spec No 1(1):219-27.
Dance therapeutic workshop for elderly people living in a home.
Elderly persons are often depressive; thus they are in loss of desire and motivation. They don’t take care anymore of themselves and seem disembodied. It is exactly on this loss of desire that arts therapies have an impact. This involvement of the body facilitates the awareness of one’s often unexploited capacities but also allows the emergence of pleasure and finally desire. Arts therapies are based on the conscience of here and now, with the perspective to become a creative being. It is the matter of helping people to recognize their own creativity that was underestimated by themselves up to here. These sessions allow the patients to go out of their room while bringing them a sensation of relaxation and well-being. They are proud to produce something by themselves and recover thus a certain self-esteem. And, through this activity, they are able to express what they feel. The statistical computations are made with the data of 10 elderly persons aged 77 to 95 years. We analyze the rating scales for self-expression through movement during 10 sessions. The subjects also filled in the Campbell’s Index of Well-being in T1 and T2. Arts therapies improve in a significant way the cognitive functioning and the psychological well-being of elderly persons, as well as their quality of life.
Bull Soc Sci Med Grand Duche Luxemb. 2010;Spec No 1(1):205-17.
Comparative study on elderly and disabled subjects with various degrees of dementia.
This study aims at showing the positive effects of arts therapies in individual and group sessions, with an aging, valid or dependent population, presenting symptoms of dementia or not. The improvement of cognition (including memory), well-being, as well as of certain medical problems (pain, tension…) was underlined in several studies on arts therapies, including especially the use of music therapeutic techniques. Indeed, music stimulates the emotional memory, causing the emergence of ancient memories, thus restoring narcissism. The well-being of participants is increased. Our population consists of elderly people, most of them suffering from dementia. They come to the workshops by themselves or led by their families. Music but also pictorial arts are used as a therapeutic mediation for one session per week during the time of hospitalization. This period varies depending on the condition of the subject.
The scales used in T1 and T2 with patients suffering from dementia are the Echelle d’appréciation clinique en gériatrie by Bouvard & Cottraux and the Fragebogen zur Beurteilung der Behandlung durch den Therapeuten (FBB-T) by Mattejat and Remschmidt. Regarding the criteria for external validation, a semi-structured interview is proposed to the nurses in T2. The scales used with valid people are the Index of Well-being by Campbell et al, the Hospital Anxiety and Depression Scale (HADS) by Zigmond and Snaith, the Rosenberg Self-esteem Scale (RSES), validated by Vallières and Vallerand in 1990, and the Stressverarbeitungsfragebogen (SVF 78) by Janke et al. CDC: There was a positive effect for most seniors who attended the sessions: an increased well-being and a temporary appropriation of memories. However, given the small size and the heterogeneity of samples, the irregularity of attendance, the results cannot be generalized. More regular sessions of arts therapies would be favorable for a consolidation of results.
Bull Soc Sci Med Grand Duche Luxemb. 2010;Spec No 1(1):167-79.
The influence of music on pictorial expression of young women–a comparative study of different music styles].
Schiltz L, Maugendre M, Brytek-Matera A.
Questing one’s personal identity and developing a coherent representation of oneself, the other and the world are major tasks in adolescence. Research showed that a satisfactory resolution of the crisis of adolescence can be favoured by psychological counselling based on artistic mediations. The objective of this study consisted in exploring the effect of music on the pictorial expression of a non clinical sample of female adolescents (N=157) aged from 17 to 28 years. We analysed free drawings realised by the test group with the help of a rating scale constructed in a phenomenological and structural perspective (Schiltz, 2006). The adolescents painted under musical induction. We proposed three different styles of music, i.e. baroque music (Georg Friedrich Händel and Johann Sebastian Bach), classical music (Wolfgang Amadeus Mozart and Ludwig van Beethoven) and polish ethnical music (Kapela ze Wsi Warszawa-Warsaw Village Band). By using non parametric inferential and multi dimensional statistics, we could show that structural characteristics of music styles lead to differences in formal and content variables on the rating scales for the pictures. The results of our exploratory study open some tracks for future research. It would be pertinent to enlarge the population to other categories of age and to investigate the influence of gender.
Bull Soc Sci Med Grand Duche Luxemb. 2010;Spec No 1(1):91-107.
Forecasting financial asset processes: stochastic dynamics via learning neural networks.
Giebel S, Rainer M.
Models for financial asset dynamics usually take into account their inherent unpredictable nature by including a suitable stochastic component into their process. Unknown (forward) values of financial assets (at a given time in the future) are usually estimated as expectations of the stochastic asset under a suitable risk-neutral measure. This estimation requires the stochastic model to be calibrated to some history of sufficient length in the past. Apart from inherent limitations, due to the stochastic nature of the process, the predictive power is also limited by the simplifying assumptions of the common calibration methods, such as maximum likelihood estimation and regression methods, performed often without weights on the historic time series, or with static weights only.
Here we propose a novel method of “intelligent” calibration, using learning neural networks in order to dynamically adapt the parameters of the stochastic model. Hence we have a stochastic process with time dependent parameters, the dynamics of the parameters being themselves learned continuously by a neural network. The back propagation in training the previous weights is limited to a certain memory length (in the examples we consider 10 previous business days), which is similar to the maximal time lag of autoregressive processes. We demonstrate the learning efficiency of the new algorithm by tracking the next-day forecasts for the EURTRY and EUR-HUF exchange rates each.
Bull Soc Sci Med Grand Duche Luxemb. 2010;Spec No 1(1):77-89.
Using the partial least squares approach for comprehending the motivational factors in the activity of consuming psychoactive products in adolescents].
Practice of a sport is associated with better health but it can also be linked to behavioral disorders of adolescents. It is therefore necessary to identify what influences these health problems.OBJECTIVE: We evaluated the effect of sports motivation and achievement goals on the substances use of adolescents using the PLS approach. A proposal for modelling with latent variables creating motivational and consumption of substances has been conducted among adolescents over a period of 20 months. Method: This research was conducted among 105 adolescents aged an average of 17 years.
RESULTS: The analysis of data in PLS has revealed the essential role of sport motivation and achievement goals in the behavioral disorders in adolescence. We also made a comparison of PLS with a statistical regression classic.
Bull Soc Sci Med Grand Duche Luxemb. 2010;Spec No 1(1):69-75.
Application computing frequency–analysis of sensory dating for determining the sulfide load.
Giebel S, Romaker J, Frechen FB.
Bull Soc Sci Med Grand Duche Luxemb. 2010;Spec No 1(1):41-51.
Shape analysis of retroperitoneal tumors in childhood in magnetic resonance imaging.
Giebel SM, Schiltz J, Graf N, Schenk JP.
2D-shape analysis of biological objects is described first in 2007 with MRI-data (magnetic resonance imaging) of renal tumours of infancy. For shape analysis the evaluation of landmarks is necessary (n >2). In this study 24 landmarks are selected. Every object is described by these landmarks. The shape is the standardised and centred object. The procedure is applied on transversal as well as on frontal images. The results for frontal and transversal images are compared. Tumours of different origin, topography and size can be analysed. The differentiation of relevant landmarks is important for statistical and medical reason. In this study, evaluation of landmarks and their possibility for tumour differentiation is demonstrated.
Bull Soc Sci Med Grand Duche Luxemb. 2009;(2):131-3.
Early decompressive hemicraniectomy in fulminant herpes simplex encephalitis.
Maraite N, Mataigne F, Pieri V, Dang T, Diederich NJ.
Herpes encephalitis can be a life-threatening condition, despite early instauration of acyclovir treatment. In particular patients may succumb to rapidly progressive cerebral oedema. We report a 66-year patient with a Glasgow Coma Score (GCS) of 6 and incipient uncus herniation of the right temporal lobe on the third day. Decompressive hemicraniectomy was immediately performed. The long-term outcome was satisfactory with unassisted gait and a Barthel Index score of 70 after 9 months.
Bull Soc Sci Med Grand Duche Luxemb. 2009;(2):163-70.
Telemedicine assisted diet and diagnosis management in food hypersensitivity.
Rösch N, Arens-Volland A, Harpes P, Herbst R, Plumer P, Feidert F, Schmalz P, Mösges R.
Several studies have shown that the current prevalence of food allergy in Western Europe is about 4% and will further increase. Because of missing therapeutic alternatives, food allergy patients are required to identify individual allergens in the daily food by carefully reading the product’s ingredient lists.
Experiences with other chronic diseases show that a combination of telemedicine and Disease Management (DM) could have a positive impact on medical outcome and health related costs. A new concept of telemedicine support for allergy patients and allergists has been elaborated within the Luxembourgian MENSSANA project.
Instead of measuring physiological parameters, a Smartphone based Personal Allergy Assistant (PAA) allows patients to keep an electronic patient diary by scanning the barcode of the consumed food products. For diagnostic purpose, the diary is regularly transmitted to the allergist’s electronic patient record. To further support the individual diet management, the PAA gives a warning before consumption of allergenic food. Computer readable food ingredient lists are required for the PAA diet management. To collect this kind of information, a dedicated web-based “virtual community” of food consumers and producers
(www.wikifood.eu) has been established. This volunteer network complements an independent product database. Up to now, more than 13.000 food descriptions are public available within wikifood.eu.
Bull Soc Sci Med Grand Duche Luxemb. 2009;(2):141-52.
Results of the ALEGRIA study in Luxembourg. An epidemiological, observational study to describe symptom impact and control in patients with GERD and an evaluation of the GERD Impact Scale.
Fritz R, Goodman N, Duquenne V, Taeter C.
BACKGROUND AND STUDY AIMS: The aim of this observational study was to perform the first epidemiology study in a primary care patient population with GERD in the Grand Duchy of Luxembourg and to evaluate the added value of the GERD Impact Scale (GIS) patient questionnaire.
PATIENTS AND METHODS: 152 Patients with symptoms of GERD from 20 study centers were included. At visit 1, demographic data including lifestyle factors and the patients’ symptoms were recorded. GERD symptoms and their severity, treatment changes and the GIS were all assessed at baseline (visit 1), visit 2 (4-6 weeks) and visit 3 (8-14 weeks). Analyses were performed on an intent-to-treat basis.
RESULTS: 142 patients were included in the analysis, which comprised 50% men and 50% women with a mean BMI of 27 kg/m2. Documented lifestyle factors included consumption of caffeine-containing beverages (87% of patients), stress (62%) and alcohol consumption (53%); 44% of patients were smokers or ex-smokers. The median duration of GERD was 2.0 years. Upon inclusion, 46% were receiving, or had received, proton pump inhibitors (PPIs), antacids (44%), H2-receptor antagonists (21%) or no treatment (21%). PPIs were prescribed at the first visit in the majority of cases (94%) with 75% of patients being prescribed esomeprazole with a median daily dose of 40 mg. The GIS score correlated well with the clinician’s judgment of symptom severity and was reported to help determine the appropriate treatment and evaluate the patient’s response in approximately 80% of patients.
CONCLUSIONS: In this, the first epidemiological study on GERD patients in the Grand Duchy of Luxembourg, data was obtained as planned. The novel patient questionnaire was judged to be helpful by the physician and data shows that the GIS may have an added value over current assessments.
Bull Soc Sci Med Grand Duche Luxemb. 2009;(2):115-29.
Measurement of ventricular twist by 2D speckle tracking early after acute myocardial infarction. Comparison between anterior and inferior infarction.
Blasen C, Codreanu A, Robert F, Meniconi N, Beissel J, Wagner DR.
INTRODUCTION: Left Ventricular twist (LV twist) is defined as the apical counter-clockwise rotation relative to the clockwise basal rotation. It has been shown that LV twist decreases after myocardial infarction (MI) and that it is well correlated with left ventricular ejection fraction. Most studies have only evaluated anterior wall MI. The aim of our study was to determine whether LV twist is dependent on the infarct territory (anterior vs. inferior) and whether there is a correlation between LV twist and matrix metalloproteinase-9, a marker of LV remodeling.
METHODS: We measured LV twist using echocardiography with 2D speckle tracking in patients with acute MI and in a control group.
RESULTS: We evaluated 27 controls and 35 patients with acute MI, 15 with anterior wall and 20 with inferior wall MI. LV twist was significantly decreased after MI, compared to the control group (10.93 +/- 2.05 vs 15.5 +/- 2.29; p = 0.003). There was no difference between anterior and inferior MI. LV rotation was decreased in the infarct area. We did not observe a correlation between LV twist and MMP-9, or creatine phosphokinase.
CONCLUSION: With this study we confirm that LV twist decreases after acute MI. Moreover, we show that LV apical rotation is mostly decreased after large anterior MI. As apical rotation is important for ejection and aspiration (untwisting), this could be a possible mechanism of LV dysfunction after MI.
Bull Soc Sci Med Grand Duche Luxemb. 2009;(1):79-87.
C-reactive protein to initiate or withhold antibiotics in acute respiratory tract infections in adults, in primary care: review.
Rausch S, Flammang M, Haas N, Stein R, Tabouring P, Delvigne S, Holper D, Jentges C, Pieger M, Lieunard C, Iliescu C.
BACKGROUND: There is a discrepancy between the incidence of viral pathogens and the frequency of prescribing antibiotics for acute respiratory tract infections (ARTIs). Typically, primary care physicians have few possibilities to order sophisticated laboratory tests to help distinguish viral pathogens from bacterial pathogens. C-Reactive Protein (CRP) measurement could help the primary care physician to discriminate more easily between these two conditions, and should contribute to reducing unnecessary prescribing of antibiotics during the first patient consultation.
METHODS: A literature review was performed in order to see what is known and tested about CRP measurement in ARTIs in adult patients in the primary care setting, to assist GPs in their decision whether or not to prescribe antibiotics.
RESULTS: Out of 54 entered articles reviewed from 109 abstracts, we could identify 8 articles which correspond to our selection criteria. Overall the methodological quality of the studies is heterogeneous. Specificity and sensibility of CRP measurement in ARTIs in adults vary widely from as low as 10% to as high as 99%.
DISCUSSION AND CONCLUSION: Current literature is insufficient and too heterogeneous to allow conclusions about the value of CRP measurement to support the decision of prescribing antibiotics for ARTIs in adults, in primary care. Most studies tested CRP in view of an aetiological diagnosis of ARTIs, whereas common practice in primary care is oriented pragmatically towards risk management and watchful waiting when ‘dangerous’ symptoms are absent. We found sufficient evidence that CRP would be a useful biomarker in this perspective, but thorough and rigorous studies are needed to test this hypothesis.
Bull Soc Sci Med Grand Duche Luxemb. 2009;(1):57-65.
The athlete’s foot: the grey zone behind the ankle.
van Giffen N, Seil R, Pape D, Nührenbörger C.
Posterior ankle and heel pain is common among athletes. The most common injury in this region is that of the Achilles tendon. However, besides the Achilles tendon, pain can originate from a retrocalcaneal bursitis, posterior impingement syndrome, os trigonum syndrome, or flexor hallucis longus tenosynovitis. These pathologies often caused by overuse, but can also occur after trauma. With careful examination, and the help of MRI imaging, the distinction can be made among these pathologies and the more common Achilles tendon problems. Like most overuse injuries, the majority of cases of retrocalcaneal bursitis, posterior impingement, flexor hallucis longus tenosynovitis respond to conservative treatment. However, when this fails, open or arthroscopic surgery can be proposed. Arthroscopy is less aggressive than open surgery, with the added advantage of less patient morbidity, less post-operative pain, and early functional rehabilitation. It is becoming the surgery of choice, especially among athletes.
Bull Soc Sci Med Grand Duche Luxemb. 2009;(1):27-43.
Antiphospholipid antibody syndrome.
Chakoutio V, Ries F.
An Antiphospholipid syndrome (APS) was diagnosed in a patient who had massive pulmonary embolisation from a right atrial thrombus. The (APS) is an autoimmune disease defined by the presence in the serum of at least one type of autoantibody known as antiphospholipid antibody (aPL) and the occurrence of at least one clinical feature from a list of potential disease manifestations, the most common of which are venous or arterial thrombosis, recurrent fetal loss and thrombocytopenia. The prevalence of APS in a series of patients from internal medicine is 2 percent. The mean age at diagnosis is 42 years. The pathogenesis of APS associated with clinical manifestations seems to result from a variety of effects of aPL on coagulation pathways,but the exact mechanism of action of aPL on these pathways is not completely understood. The APS can be primary or secondary to a disease. Thrombosis is the most frequent clinical manifestation of APS. It involves many organs, resulting on multiorgan failure: this is the catastrophic APS. The treatment is the same whether the APS is primary or secondary. It is mainly symptomatic and consists in the prevention of thrombosis at short and long-term by using aspirin and/or anticoagulants. Immunomodulating treatment can be offered but its efficiency at long-term is unproven. The mortality varies according to the etiology and the clinical manifestations. The mortality rate is 50 percent in catastrophic APS, despite treatment.
Bull Soc Sci Med Grand Duche Luxemb. 2009;(1):11-25.
A cross-cultural examination of the relationship between negative mood states, body image and eating disorders.
Brytek-Matera A, Schiltz L.
The present study investigated the relationship between depression and anxiety symptoms, body image and disordered eating behaviours in Polish and French populations. In addition, our study was also designed to explore durability and intensity of depression and anxiety symptoms in both anorexic groups.
Participants were 95 adolescent girls suffering from anorexia nervosa and 95 healthy women. All participants completed the Hospital Anxiety and Depression Scale and Eating Disorder Inventory. An analysis of variance (ANOVA) indicated that the depression score of Polish anorexic patients was significantly higher than those of French adolescents. Compared with the control group without eating disorders, both anorexic group experienced significantly higher anxiety and depression symptoms. Anxiety and depression levels were found to have increased with the Polish women’s age and Body Mass Index. They were independent of the illness duration for both in Polish and French patients suffering from anorexia nervosa. The results of Pearson’s correlations show that, in the Polish group, the higher anxiety is, the higher maturity fears and interoceptive awareness are. Furthermore, in the French group, the higher depression is, the higher bulimia, ineffectiveness, interpersonal distrust, interoceptive awareness and maturity fears are. The results are discussed in terms of the important role of mood and anxiety symptoms in eating disorders.
Bull Soc Sci Med Grand Duche Luxemb. 2009;(1):7-9.
A case of acute haemolysis with 2 different multi target thyrosine kinase inhibitors in a patient with renal cancer.
Berchem G, Dewilde S, Mahassen P.
We report the case of a 78-year-old man diagnosed with metastatic renal cell carcinoma developping acute haemolysis under Sunitinib as well as under Sorafenib. This side effect induced a definitive withdrawal from the drugs. As these drugs are used more widely, rare side effects are bound to appear.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(3):353-69.
Advance directives in Luxembourg: legal aspects.
Actually in Luxembourg law, article 43 from the law dated 28th August 1988 about the medical centers and articles 40 to 44 of the professional code of ethics of the medical professions are dealing with the issue people’s end of life situations. Except article 44 of the before-said code stating the principle according to which the physician has to take into account the wills expressed by the patient with regards to his end of life, there are no legal texts defining the ruling of the advanced directive. The legislator has set into place a bill of law (doc.parl.5584) dealing with the issue of advanced directive and the support giving at terminally ill patients.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(3):345-50.
Advance directives: the situation in Luxembourg.
In Luxembourg, there exist two very different bills, which among other themes, deal with advanced directives. The two bills are first described globally, then they are analyzed more specifically regarding their stipulations concerning living wills, including the ethical background.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(3):339-43.
Legal comparisons between States: the Italian perspective.
In Italy compared to the past the doctor-patient relationship has changed, but at the present it is necessary to improve the patient’s involvement into the clinical and medical decisions regarding his own health: the patient is a moral subject and the possibility to choose should be recognized especially for the end-of-life decisions.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(3):289-97.
Characteristics and aims of patient advance directive laws.
The advanced directive law (PatVG), which regulates the conditions and effectiveness of living wills, has been in force since 1 June 2006. A living will is a declaration of will with which a patient refuses certain medical treatment for the case that he is no longer able to understand the situation, make ajudgement or to express himself. In contrast to the non-anticipatory rejection of treatment, the legislator demands, in the case of anticipatory rejection, the fulfilment of certain conditions. The law provides for two forms of living will 1. the non-binding living will and 2. the binding living will. In the case of a binding will, if the patient is no longer able to understand the situation or to make a judgement and/or is unable to express himself, the doctor has to respect the living will and under no circumstances is allowed to carry out the measures which the patient has refused. If one conditions for a binding living will is not fulfilled, the will is then non-binding. However, the greater the number of conditions which are fulfilled, the more likely it is that a doctor will consider it binding. In all cases, the binding living will serves as an aid for the doctor to indicate the will of the patient.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(3):259-64.
Bulletin of the Medical Science Society of the Grand Duchy of Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(3):257.
The anticipated directives–international comparisons of legal and ethical points of view. Analysis, reflection, dialogue.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(4):559-64.
Localized prostatic cancer: treatment exclusive by radiotherapy guided by imagery, experiences in Luxembourg in 2005 and 2006.
Untereiner M, Renard-Oldrini S, Mecellem H, Burie D, Lassen Y, Phy RR, Phy SJ, Phy LH.
Exclusive radiotherapy is one of therapeutic standard in the curative treatment of localized prostate cancer. Results are equivalent when compared with other treatment regimens (radical prostatectomy or curietherapy) in localized forms. However, the patients risks profiles to predict noxious effects are different. Between 2005 and 2006, 27 patients have been treated with intensity modulated radiation therapy and image-guided radiotherapy (IGRT), after implantation of gold markers to target prostate localization during daily radiotherapy seances.
The total dose of radiation delivered in prostate is 74 Gy with respect to the maximal dose defined to the rectum and to the bladder. Late toxicity was limited to grade 2 (rectitis and cystitis). These symptoms were temporary. One patient out of 20 patients with one-year follow-up experienced biological recurrence with metastasis progression. New radiotherapy technologies have allowed to reduce the incidence of the toxicity especially late rectal toxicity (2.2% in 2006) within a limited time period (one-year minimum).
Bull Soc Sci Med Grand Duche Luxemb. 2008;(4):551-7.
Radiotherapy after prostatectomy: experiences in Luxembourg from 2005 to 2006.
Untereiner M, Renard-Oldrini S, Mecellem H, Burie D, Lassen Y, Phy RR, Phy SJ, Phy LH.
Radical prostatectomy is a therapeutic option for the treatment of localized prostate cancer (T1 and T2). The prognostic factors which define risks of recurrence after prostatectomy are: capsular invasion, invasion of resection margins, seminal vesicle invasion. Two randomized trials show that adjuvant radiotherapy improves local control and biochemical recurrence-free survival.
Between 2005 and 2006, 12 patients of Centre François Baclesse have been irradiated on theprostatic loge. Immediate post-operative radiotherapy was preferably used. Late toxicity (grade 1) occurred only in one patient (1 case out of 8). Based on the literature, immediate postoperative irradiation is preferentially proposed in case of unfavourable factors, or possibly used secondly, in case of biological recurrence (in early situation i.e. PSA < 0.5).
Bull Soc Sci Med Grand Duche Luxemb. 2008;(4):521-39.
Testicular cancer in Luxembourg: incidence and outcome in relation to the different histo-pathological types (1980-2004).
Scheiden R, Hein T, Wagener C, Kieffer N, Lamy S, Capesius C.
BACKGROUND: Increasing incidence rates of testicular cancer have been reported worldwide over the last three decades. Trends over time in the incidence rates of germ cell tumours (GCTs) in Luxembourg (Western Europe) and the outcome, both in relation to the different histological types, were analysed.
METHODS: The population-based files of the Morphologic Tumour Registry collecting at a nation-wide level all testicular cancers diagnosed between 1980 and 2004 in the central department of pathology in Luxembourg were retrospectively reviewed. In addition, the presence of concomitant malignant diseases was investigated.
RESULTS: 397 patients with GCT were evaluated. The mean age was 33.7 years (range: 1-72). Most of the patients (58.7%) were between 15 and 34 years of age. The age-standardized incidence rates rose from 4.5 per 10(5) (1980-1984) to 7.7 per 10(5) (2000-2004). Out of 275 (69.3%) pure GCTs, 218 seminomas, 48 embryonal carcinomas, 4 yolk sac tumours, 4 malignant teratomas and 1 choriocarcinoma were identified. 30.7% GCTs were of mixed type with 17 different histological variants. 5.8% of the patients had metachronous concomitant cancers, 2% bilateral GCTs and 3.8% non-testicular neoplasms. In all histological categories, with the exception of the pure seminomas, prognosis was determined within the 24 months following diagnosis; pure seminomas need long time follow-up. Ten-year observed survival rates exceeded mostly 90%. Pure embryonal carcinomas had the worst prognosis with a 10-year observed survival rate of 87.1 +/- 12%.
CONCLUSIONS: Testicular germ cell tumours are rare, highly curable neoplasms that generally occur in young patients. In all histological categories, except for pure seminomas, prognosis was determined within the 24 months after diagnosis. Despite better observed survival rates, patients with pure seminomas, without or with metachronous concomitant non-testicular malignancies, need long time followup strategy.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(4):517-20.
Androgen-secreting tumor in an adrenal tumor discovered by accident after amenorrhea caused by a meningeal hemorrhage.
Oprea I, Michel G.
Androgen-secreting tumors are uncommon among adrenal secreting tumors. The case reported here concerns an adrenal tumor secreting androgens, unexpectedly found after a sudden amenorrhea caused by a meningeal haemorrhage, with positive outcome after adrenalectomy. The indication of increased secretion of oestrogens and androgens, should suggest the presence of adrenal androgen-secreting tumor.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(4):509-16.
Pan-European survey on the undertreatment of hypercholesterolemia in hypolipidemias(Luxembourg).
Michel G, Muller P.
Cepheus (Centralized Pan-European survey on the undertreatment of hypercholesterolemia) is an observational centralized study realized in 8 European countries including Luxemburg. The aim was to evaluate the percentage of patients reaching the TJETF and 2004 NCEP ATP III recommendations for LDL-cholesterol. A secondary aim was to identify by questionnaires the determinants of patients and physicians explaining this undertreatment. Data from 706 patients in Luxemburg have shown that only 40.6% of patients and only 17.5% of high risk patients (CVD and diabetes) reach the newest european target values of LDL-cholesterol (post-hoc analysis). 90% of patients had statins prescribed and 9.7% fibrates. 60% of patients had still the same medication at the same dosage at the moment of the study, after at least 3 months treatment with a mean of 6.2 years. 40% of patients said that they forget sometimes their treatment and 13% were convinced that forgetting their tablets more than once a week did not affect their cholesterol level. These disappointing results could be due partly to insufficient dosages, too less adaptation of the treatment and a bad compliance of patients.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(4):497-502.
Biological parameters for evaluation of ovarian reserve and resultant antimullerian hormone.
Arendt J, Schilling C, Peiffer M.
No biological parameter allows a predictive result in ART for ovary stimulation. We studied the interest of dosing AMH in ovary stimulation in balance with the the clinical context.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(2):307-15.
Doctor Charles Marx 1903-1946.
Charles Marx (1903-1946) an outstanding Luxembourg physician was a communist. He had very well succeeded in his medical studies in Paris starting as an interne (1929), to become “chef de clinique chirurgicale”, then a “Lauréat de l’Académie de Médecine” and finally a member of the “Comité de l’Association française de Chirurgie” (1935). He founded his own hospital (50 beds) in Ettelbruck. There, in 1940, he helped two interned French airmen, to escape to France. Charles Marx escaped himself, with his family, just before the German invasion. He briefly directed four French hospitals, in Nevers and in Quillan. In July he founded the first resistance group of the “Armée secrète”, which in May 1943 was followed by a first maquis in the western Pyrenees. In June 43, he was condemned to death “in absentia” in Montpellier by the Nazis. In February 1944 Charles Marx was appointed medical commander of the FFI and chief health manager of the Resistance in the oriental Pyrenees. In September 1944 he took part in the liberation of Lyon. In October, being the delegate of the medical resistance council, he was named attaché to the Health Minister and was charged to organize French-American military surgical structures. End of July he took up the management of the Ettelbruck hospital. In November 1945 he was nominated minister of Public Health in Luxembourg. In June 1946 Charles Marx and his Rumanian wife lost their lives in a car accident.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(2):259-79.
Lucky National Registry (Luxembourg Acute Myocardial Infarction Registry). Are women much better taken care of than men?.
Oprea I, Vaillant M, Hesse M, Jacobs L, Beissel J, Wagner DR.
The national LUCKY registry (Luxembourg Acute Myocardial Infarction Registry)confirms for Luxembourg that transfer of patients with acute myocardial infarction for primary percutaneous coronary intervention (PCI) is very effective. However, while mortality is low after PCI, a third of the patients with acute myocardial infarction develop severe left ventricular dysfunction.
This may in part be explained by relatively long time delays between onset of symptoms and opening of the infarct-related artery, despite short distances between hospitals (time is myocardium). Surprisingly, in comparison with men, women are younger, have a higher body mass index and receive less evidence-based therapies such as statins before and after myocardial infarction. In conclusion, PCI has substantially improved the treatment of acute myocardial infarction in Luxembourg, but all actors including the patient have to keep efforts high to minimize time delays.
Bull Soc Sci Med Grand Duche Luxemb. 2008;(2):197-208.
Day care hospital in psychiatry: diversity or specificity?.
d’Albis MA, Pull C.
Day Care Hospitals represent efficient structures for the treatment of various psychatric disorders through a large variety of medical care. In the litterature, multiple terms are used to define the various models of Day Care Hospitals, according to their use, their orientation and their therapeutic programmes. Our aim in this study is to compare, through a search on “Medline”, the various existing models of Day Care Hospitals in France and in Belgium. Thereafter, the “specific” model which exists at the Centre Hospitalier du Luxembourg will be described. Two main types of Day Care Hospitals are described in the litterature: the “classical” type, with mainly a support fuction, resides on the downstream side of hospitalisation and the “specific” type, with a care function for a short duration, resides on its upstream side. The model developed at the Centre
Hospitalier du Luxembourg is upstream the hospital. From our study, it is concluded that, rather of being an inconvenience, the large number of existing Day Care Hospitals, which differ by various specificities, represent excellent complementary opportunities for the current care of mental diseases.
Bull Soc Sci Med Grand Duche Luxemb. 2008;Spec No 1:175-88.
Analysing the relationship between traumatic biographical events and the current structural functioning of personality.
Schiltz L, Schiltz J.
We present the general structure of a multi-annual research project. Our general expectancy concerns the possibilities of arts psychotherapy as a means of launching the blocked process of subjectivation with people suffering from exclusion, precarity and marginalization. The research project follows a complex research design with a sequential strategy, the first part consisting in an integrated psychosocial and clinical study using a mixed methodology. We constructed special rating scales for the analysis of the data of a semi-structured biographical interview and also for the holistic interpretation of the Rotter Blank Sentences Test, separating the associations to sentences beginning with the third and first person. The correlations between two sets of variables (biographical interview and Rotter test) were computed for the total experimental group (N=206), and for clinical subgroups. We shall analyse the matrices of correlations (Spearman’s Rho) with the help of optimal scaling procedures (OVERALS). The links between traumatic biographical events and responses to the 3rd, respectively 1st person items of the Rotter test are interpreted in terms of unconscious versus conscious psychological processes and allow us analysing the expression of defence mechanisms and coping strategies. The results of the study are discussed in the light of the recent traumatogenic hypothesis of borderline functioning.
Bull Soc Sci Med Grand Duche Luxemb. 2008;Spec No 1:165-73.
Comparative study of two kinds of addictive behaviour; smoking and drug abuse. Interest of arts psychotherapy.
The aim of the study consists in showing differences between addiction to tobacco, and to illegal drugs in terms of self-regulation skills, anxiety and depression. These two kinds of dependency are considered to take place on a continuum of addiction. Researches on emotional troubles in addictions have shown that there was a lower level of emotional awareness in patients with addictive behaviour, when compared with normal controls. As arts allow a better access to the emotional register, this kind of psychotherapy seems to be very interesting in cases of addiction. The comparison will be based on the HADS, with its two subscales of anxiety and depression, and on the SRSS, with the following subscales: avoiding distraction, control-regulation, planning, self-efficacy. From the results of our comparative study, we shall draw conclusions allowing us adapting our treatment by arts psychotherapy to different kinds of addictions.
Bull Soc Sci Med Grand Duche Luxemb. 2008;Spec No 1:131-43.
Singing for preterm born infants music therapy in neonatology.
The use of music as part of a stress reduction therapy has been applied both to premature infants and their parents in the Neonatal Reanimation Service. This aim of music therapy amounts to an attempt to help the premature infant regaining its physical and neurological balance, so important to its psychological and physical development, mainly by masking the sometimes excessive noise present in the intensive care unit and/or in the incubator. Studies have demonstrated the positive impact of music therapy on oxygen saturation, heartbeat, and on the general level of relaxation experienced by premature infants. In this project, the palliative technique used was that of live singing, directly to the infant, accompanied by a pentatonic harp. The aim was to improve the state of health, both physical and psychological, of a group of premature infants, whose gestation period varied between 23 and 36 weeks. The technique used was to apply what amounts to a protective cocoon of sounds to a premature infant in the neonatal unit, which measurably reduced the level of stress as indicated by the babies’ increasingly relaxed demeanour and induced a measurable increase on the level of oxygen saturation and a reduction of heart rate.
Bull Soc Sci Med Grand Duche Luxemb. 2008;Spec No 1:111-9.
Non linear principal component analysis and clues for a differential approach of five groups experiencing social precariousness.
We wished to develop an original way of taking care of people experiencing great social precariousness. Our purpose was to develop communication and relational skills, to stimulate expression of emotions and feelings, to bring out personal resources, to increase well-being, motivation and self-esteem, and thus favour rehabilitation. Our sample is composed of long-term unemployed people, of people benefiting from measures of integration into the working process, of people living in community homes, of drug addicts, and of drug-addicted female prisoners. Our research is based on an integrated quantitative and qualitative methodology, with rating scales for the artistic production and observational frames for items of verbal and non-verbal behaviour completing the psychometric questionnaires. It is an action research; we use art therapy, which is a common practice in the health sector, especially with subjects having problems expressing there feelings through words. We have carried out a non linear principal component analysis (PRINCALS) on the data of the projective test (Rotter), as well as a between groups comparison of the responses to the questionnaire on life satisfaction (FLZ), with the help of the Mann-Whitney test. It is from these comparisons that we are able to draw out a few clues for differential treating strategies, depending on the inclusion into the five sub-groups that we have followed.
Bull Soc Sci Med Grand Duche Luxemb. 2008;Spec No 1:75-90.
Extracting specific profiles in two clinical subgroups of patients suffering from addiction.
According to research literature, people suffering from addiction to alcohol or illegal drugs are presenting well defined troubles of identity. The aim of this study consists in showing structural similarities and differences between those two clinical subgroups, with the help of the Rorschach test which we have interpreted in an integrated quantitative and qualitative manner. We constructed a rating scale for the test of Rorschach, following the phenomenological and structural tradition of Mucchielli. This rating scale is considering as well the special phenomena as the global judgment of the experienced clinical psychologist. It is differing from the classical psychogramme by its holistic perspective, as it takes into account the interaction of different factors in a specific context. In an exploratory perspective we applied this rating scale to the Rorschach protocols of two small samples of people suffering from alcoholism and of people suffering from drug addiction. The patients belonging to both subgroups were in a state of abstinence at the period of the test. Thus their answers are reflecting an interaction of their basic personality and long term effects of the toxic products, but not the immediate effects of alcohol or illegal drugs. We have compared the answers of the two subgroups of dependent people with the help of non parametric statistics. Their specific profiles have been extracted with optimal scaling techniques. The results are discussed in relationship with structural psychopathology.
Bull Soc Sci Med Grand Duche Luxemb. 2007;(2):155-77.
History of the cesarean section “post-mortem”.
During the 18e century the catholic church insisted on christening babies suffering in the womb of their mother. Midwives and doctors were obliged to baptize the children, or inside the uterus, or after cesarian section done after death of the mother. We found 28 cesarian sections done in dead women in Luxembourg by surgeons or by midwives.
Bull Soc Sci Med Grand Duche Luxemb. 2007;(2):131-40.
Pleural effusion–which diagnosis is significant?.
Although many different diseases may cause a pleural effusion the most common causes are congestive heart failure, pneumonie, and cancer. The first step in the diagnosis of pleural effusion is the distinction between exudates and transudates. Because of their high sensitivity Light’s criteria, which differentiate transudative effusions from exudative effusions by measuring the levels of total protein and lactate dehydrogenase in the pleural fluid and serum, have become the standard method for making this distinction. Aim of this article was to mention the various parameters and their usefulness in closer characterication of pleural effusion.
Bull Soc Sci Med Grand Duche Luxemb. 2007;(2):125-30.
Creutzfeldt-Jakob disease with slow progression. A mimickry of progressive supranuclear palsy.
Huber FM, Bour F, Sazdovitch V, Hauw JJ, Heinemann U, Zanini F, Droste DW, Diederich NJ.
Sporadic Creutzfeldt-Jakob disease (sCJD) does not always present with typical clinical signs, such as myoclonus in association with periodic sharp-wave complexes. We present a 67-year old female patient with initial falls and vertical gaze palsy, suggesting the diagnosis of Progressive Supranuclear Palsy (PSP). EEG and MRI were not contributory. Typical clinical and paraclinical CJD signs were only seen after 17 months. The diagnosis was confirmed by autopsy. – CJD can be a neurodegenerative chameleon. The present case adds to the scare literature of slowly evolving CJD mimicking Parkinsonism related to tauopathies.
Bull Soc Sci Med Grand Duche Luxemb. 2007;(2):109-24.
Ongoing medical problems in the anti-doping fight.
Delagardelle C, Ries F, Feiereisen P, Urhausen A.
Over the last 20 years systematic doping has become a major threat for elite sport. So far, there is no clear information about the daily practice of doping. Repeated scandals and recent personal statements have added to our knowledge. Several more recent doping agents like Erythropoietin (EPO) and, probably, growth hormone (GH) enhance performance in a highly effective way and, together with the well known anabolic steroids (AAS), belong to the major doping categories. The introduction of EPO has really changed the paradigm in endurance sports allowing a good middle class athlete to become a champion. It is evident that doping practices are influenced by the possibilities of the anti-doping control system. Unethical, criminal medical doctors play a decisive role in the ongoing practice of major doping. Apart from the already mentioned substances AAS, EPO and GH several novel drugs appear on the horizon. They are highly effective and there is no doubt that they will be used in attempts to improve performance. During the last years, doping control systems have also been improved: EPO can now be detected in urine samples and the detection of AAS has also become much more sensitive. However GH hormone detection is not possible at the moment and this remains a major weakness of doping control. Other problems are the control procedures which are far from being optimal. In the future the quality of doping controls will be decisive and not only the quantity; controls will have to be “intelligent”. The effective fight against doping in the next years will decide about the survival of elite sport.
Bull Soc Sci Med Grand Duche Luxemb. 2007;(2):103-6.
Toward many academic years.
Bull Soc Sci Med Grand Duche Luxemb. 2007;(1):7-15.
Ethical preoccupations in the daily practice of medically assisted reproduction in the Grand Duchy of Luxembourg.
Ethical questions are daily in usual ART practice. The answers differ from the existence or not of legal resolutions. In Grand Duchy of Luxembourg, there is no law on ART practice, by now. Practice is based human sense, ethical commission guide lines and partly on French bioethical law July, 1994. We discuss several topics encountered in daily practice.
Bull Soc Sci Med Grand Duche Luxemb. 2007;(1):55-66.
Objectives and realizations in the European Federation of Medical Societies.
Bull Soc Sci Med Grand Duche Luxemb. 2007;(1):39-54.
Restless legs syndrome.
Droste DW, Diederich N.
About 7% of the population are affected by the restless legs syndrome (RLS). The most invalidating subjective complaints are dysesthesia / pain / an urge to move the legs (46%), an alteration of sleep (38%), and difficulties in performing activities of daily life (7%). The onset of the disease is variable, ranging from childhood (often unrecognised) to old age. The clinical course is generally chronic with phases of spontaneous remission. The cause of RLS is probably mainly genetic with a dysfunction of iron and dopamine metabolism accentuated by peripheral factors (neuropathy, radiculopathy, and temperature). There are secondary forms of RLS, such as iron deficiency (under debate), side effects of drugs (that can be stopped), renal insufficiency, radiculopathy, and neuropathy.
RLS can come up during pregnancy, in particular in the last trimenon. Treatment of aggravating factors and sleep hygiene are general measures. Drug treatment of the RLS comprises levodopa, dopaminergic drugs, opioids, and antiepileptic drugs; however, drug treatment is only necessary in about a third of the affected.
Bull Soc Sci Med Grand Duche Luxemb. 2007;(1):17-37.
Epidemiology of diabetes in the INTERREG III Province of Luxembourg, the Grand Duchy of Luxembourg, Lorraine.
Böhme P, Chamagne L.
Incidence and prevalence of Type 2 Diabetes, together with its long term complications is explosively rising. The trans-border project “INTERREG III” tries to explore the epidemiology in the 3 concerned countries and to tie a network between the health providers. Estimation of prevalence is around 3% of the adult population but rising for example in the Grand Duchy by 4.5% per year, meaning the number of affected patients will double in 16 years, mainly due to the increase in obesity. Chronic renal insufficiency will rise and the number of patients will double in 8 years. Cardiovascular diseases and peripheral necrosis explain the high rate of hospitalisations and the loss of Life-expectancy that seems to be reduced by 5 to 10 years. A cost analysis in this article reveals the necessity of primary and secondary prevention programs of “diabesity” in this region, together with better multidisciplinary approaches of treatment and follow-up. This article emphasizes the need of a collaboration of all actors in the field, medical and para-medical.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(3):359-86.
Research in Luxembourg from the legislative point of view.
Since the independence of the grand-duchy of Luxembourg in 1839 it has taken a long time with complicated procedures to develop research in our country. The creation of a society for research and conservation of historical monuments goes back to 1845 followed by the Society of Natural Sciences in 1850, then by the Medical Society in 1862. Those 3 societies were at the origin of the Institut Grand Ducal. The creation of a Luxembourg institute for scientific research (CLRS) on April 1977 allowed a first public financing for research. The law of March 9th 1987 defined the type of research in 3 different centers of Public Research (CRP). On May 31st 1999 the National Fund of Research (FNR) was born. The author presents the different positions of the Council of State concerning these projects. The creation of the University of Luxembourg by law on July 7th
2003 raised many problems of coordination, collaboration and competences. Some solutions of this imbroglio are suggested.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(3):435-7.
First published results of the H5N1 mission in Nigeria: Luxembourg scholarly excitement excites world-wide progress.
[No authors listed]
Bull Soc Sci Med Grand Duche Luxemb. 2006;(3):431-3.
The thyroid and autoimmunity. The 6th Merck Thyroid Symposium from 15th to 18th of June 2006 in Noordwijk, NL.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(3):407-30.
Veterinarians–notables of the cities and the country. Some stages in their social ascent from the second half of the 18th century to the start of the 20th century.
During the second half of the 18th century scientific veterinary medicine, a new profession was born as a result of economic and military needs–losses of cattle as a consequence of infectious diseases and the growing demand for treatment to be given to the horses of the armies. At first the members of the emerging occupation, who are generally of very modest origin, hardly differ from the traditional actors of animal health. At the beginning of the 19th century the governments employ a large number of veterinarians for official missions to combat infectious diseases. As from the second half of the 19th century the skills of the veterinarians as doctors for animals and zootechnicians are beginning to be recognized by the rural population, whose increased income allows them more easily to enlist a veterinarian’s services. From the 1860s onwards they also start to play a role in the monitoring of public health by controlling foodstuffs of animal origin. But it is only at the beginning of the 20th century that new technological progress, motor vehicles and the telephone (first in the cities, then in the country by way of telephone boxes), makes their work quicker and more efficient. New and strong antiseptics for external and internal use which help to combat many infectious diseases will however appear only around the
Bull Soc Sci Med Grand Duche Luxemb. 2006;(3):387-405.
Prenatal maternal serum screening during the second trimester of pregnancy using the Triple Test in Luxembourg.
Starting in 1991, it is now an established practice in Luxembourg to use prenatal maternal serum screening during the second trimester of pregnancy. Its reliability has been investigated. Half of the pregnant population is screened, with a call back rate (false positive rate) of 5.4%. The sensitivity of the screening is 81.5%, the specificity 94.6%, with a PPV of 1.5% and a NPV of 99.9%. This is in good agreement with international findings.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(3):347-58.
Cost of disorders of the brain in Luxembourg.
Bisdorff A, Sobocki P, Cloos JM, Andrée C, Graziano ME; Cost of Disorders of the Brain in Europe Study Group.
Brain disorders (psychiatric, neurological and neurosurgical diseases) are leading causes of disease and disability. According to WHO data they cause 35% of the burden of all diseases in Europe. The present study aims to estimate the cost of defined brain disorders and adds all selected disorders to arrive at the total cost for Luxembourg. A model combining published economic and epidemiological data retrieved from the OECD (Organization for Economic Co-operation and Development) and Eurostat databases on brain disorders in Europe (EU member countries, Iceland, Norway and Switzerland) was used. We transformed and converted data for a defined period into the same currency (Euro 2004) and adjusted country specific economic data for purchasing power and relative size of economy and imputed data where no local data were available. There are an estimated 123000 people in Luxembourg currently living with a brain disorder. The total annual cost of brain disorders is estimated at Euro 500 million in 2004 or an average of Euro 1100 per inhabitant. Mental disorders constitute 62% of the total cost (excluding dementia), followed by neurological diseases (excluding dementia) 22%, neurosurgical diseases excluding herniated discs 2.2%. Direct medical expenditures (outpatient care, hospitalization, drugs) have a share of 32%, direct non-medical costs (social services, informal care, adaptation, transportation) 18% and indirect costs (sick leave, early retirement and premature death) 51%.
Bull Soc Sci Med Grand Duche Luxemb. 2005;(3):359-68.
150 years of the Central Neuropsychiatric Hospital in Luxemburg. Dr. Pierre Schmit: a psychiatrist in spite of himself?.
De Smet Y, Spautz JM.
The author discusses a “case of traditional hysteria” reported by Pierre Schmit, the first physician (1855-1866) of the Centre Hospitalier Neuropsychiatrique of Ettelbruck (Luxemburg), founded in 1855. Like Louise Lateau, a celebrated Belgian mystic living in the second half of the XIXth century, the patient suffered from ecstasy and stigma. The therapies of hysteria in this time are discussed: blood-letting, electrotherapy, clitoridectomy…
Bull Soc Sci Med Grand Duche Luxemb. 2005;(3):341-58.
Historical vignettes. History of vasculitis.
This article gives a summary of the history of vasculitis through early and past descriptions. Known, reported and depicted since time immemorial those diseases are quite polymorphous, depending on type and localization of the affected vessels. Clear classification criteria were finally laid down at the end of the XXth century giving a new impulse as well to the detection and the identification of specific biological markers as to the way to treat effectively those severe diseases.
Bull Soc Sci Med Grand Duche Luxemb. 2005;(3):317-25.
HPLC analysis of generic antiretroviral drugs purchased in Rwanda.
Schuman M, Schneider S, Omes C, Wennig R, Fundira L, Tayari JC, Arendt V.
A reversed phase HPLC method using photo diode array detection for the simultaneous quantification of lamivudine, stavudine, nevirapine, zidovudine, methyl paraben and propyl paraben in solid and liquid drug formulations was developed and validated. The separation was achieved using a Waters Symmetry C8 column, using a mobile phase gradient comprising 50 mM NaH2PO4 (pH 3.8) and acetonitrile (95:5 to 45:55, v/v) and a flow gradient (0.5 to 1.0 ml/min). The limits of detection and quantification were below 19 ng/ml and 55 ng/ml respectively. The intra- and inter-day assay precisions were within 4.4% relative standard deviations. The developed method was applied to 12 different generic antiretroviral medications, consisting of tablets, capsules and solutions, produced by two Indian manufacturers and purchased by the Central Agency of Essential Drug Procurement of Rwanda for the ESTHER project in Rwanda. The average content of the antiretroviral agent(s) compared to the labeled amount(s) was 101.4%. Methyl paraben and propyl paraben, added to solutions as preservatives, were within the FDA recommended limits.
Bull Soc Sci Med Grand Duche Luxemb. 2005;(3):307-16.
Amaurosis fugax of cardiac origin.
Michaux S, Lebrun F, Beissel J.
We present the case of a 49 year old woman who was admitted to the emergency department for dyspnoea, transient amaurosis and limbs oedema. During hospitalisation a full workup revealed multisystemic thrombosis and dilated cardiomyopathy in relation with viral myocarditis due to Coxackie B infection. Diagnosis and treatment will be discussed in light of the litterature.
Bull Soc Sci Med Grand Duche Luxemb. 2005;(3):283-92.
Psychiatric comorbidity in epilepsy.
Beyenburg S, Damsa C.
Patients with epilepsy have a high prevalence of psychiatric comorbid disorders. Many comorbidities have a significant impact on the medical management and quality of life of these patients. The main psychiatric complications in epilepsy include depression, anxiety disorders, and psychosis. Depression in epilepsy is very common, particularly among patients with partial seizures of temporal lobe origin. Despite its high prevalence, depression and other psychiatric complications remain often unrecognized and untreated in patients with epilepsy, and differential diagnosis may be difficult.. Comorbidity of epilepsy may be due to a shared pathophysiological mechanism, however, coincidence or selection bias cannot always be excluded. In addition, genetic, psychosocial and iatrogenic factors may also contribute to the comorbidity. In this review, we discuss the clinical impact of main psychiatric comorbidities and demonstrate that treatment of epilepsy extends far beyond seizure control.
Bull Soc Sci Med Grand Duche Luxemb. 2005;(3):263-81.
Current pharmacotherapy of epilepsy in adults.
The availability of new antiepileptic drugs (AEDs) has expanded the spectrum of medical treatment options in epilepsy. However, the development of ten new compounds (vigabatrin, felbamate, gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, zonisamide, and pregabalin) has not changed the basic principles of epilepsy treatment. The choice of an AED depends upon seizure type or seizure syndrome, efficacy, safety, tolerability, patient age and gender, concomitant medication, and comorbid conditions. In general, most of the newer AEDs are not necessarily more effective but usually better tolerated than the traditional agents mainly because of their favorable pharmacokinetic profiles and fewer drug interactions. Because treatment options have been widened with the introduction of these new compounds, drug therapy can now be tailored to the requirements of the individual patient. Nevertheless, significant safety and efficacy issues continue to exist and there is a strong need for the development of even better agents. This clinical review focuses on current aspects of drug
therapy in epilepsy.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(2):311-25.
Multidimensional homogeneity analysis with small samples: comparison of different subgroups of people suffering from exclusion.
Schiltz L, Houbre B.
With the aim of studying the relationship between harmful biographical events and exclusion we have developed a rating scale for semi-structured biographical interviews. The rating scale was constructed in accordance with the phenomenological and structural approach and allows us gathering some clinically pertinent indicators concerning the course of life, the nature of the trauma, the composition of the original family, the life period of emotional pain and the current familiar and social support. The homogeneity or multiple correspondence analysis (HOMALS) led to the extraction of the fundamental dimensions underlying the data of three clinical subgroups of people suffering from exclusion and marginalization: homeless and long term unemployed people, immigrants, political refugees and asylum seekers, drug addicts. The results demonstrate the relevance of the multidimensional homogeneity analysis applied to this kind of data. On one hand they suggest a theoretical model of the relationship between harmful biographical events, vulnerability, exclusion and psychopathological complications. On the other hand they show that we are facing differential psychological profiles which will be studied thoroughly during the next stages of our research.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(2):281-95.
Using fairy tales and narrative strategies with the help of a sandpit with children suffering from conduct disorders].
Our research, focussed on art therapy with primary school children, guided us to the footsteps of women pioneers in the research about children’s psyche, like Anna Freud, Melanie Klein, Margaret Loewenfeld, Dora Kalff. We have been inspired by their very personal but nevertheless somehow similar type of research, to work with the children in a blue sand pit, where they could construct and play their personal fairy tales. Thus they share with us their momentary preoccupations, without being forced to talk about them. They are revealing their internal structures, and are integrating, by narration and projection on those figurines in action, their deficient defense mechanisms as well as their negative tendencies. Based on this approach, we expect that there will by an amelioration of their social skills, an enhancement of their intrinsic motivation, and a diminution of their conduct disorders. The analyze will be done by questionnaires and rating scales constructed especially for this research, as well as by sociograms, with the help of descriptive non parametric statistics.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(2):265-80.
Rating scales based on the phenomenological and structural approach.
A current tendency of research in clinical psychology consists in using an integrated quantitative and qualitative methodology. This approach is especially suited to the study of the therapeutic intervention where the researcher is himself part of the situation he is investigating. As to the tools of research, the combination of the semi-structured clinical interview, of psychometric scales and projective tests has proved to be pertinent to describe the multidimensional and fluctuating reality of the therapeutic relationship and the changes induced by it in the two partners. In arts therapeutic research the investigation of the artistic production or of the free expression of people may complete the psychometric and projective tools. The concept of “expressive test” is currently being used to characterise this method. In this context, the development of rating scales, based on the phenomenological and structural or holistic approach allows us making the link between qualitative analysis and quantification, leading to the use of inferential statistics, providing that we remain at the nominal or ordinal level of measurement. We are explaining the principle of construction of these rating scales and we are illustrating our practice with some examples drawn from studies we realized in clinical psychology.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(2):233-47.
Explanation and forecast: relapse of juvenile offenders.
On the basis of n=82 juvenile offenders from a prison for juvenile offenders in Rheinland Pfalz the model of the logistic regression is compared with a procedure from the family of the neural nets in its efficiency to explain and predict “relapse” in form of a renewed imprisonment or prosecution /police search after dismissal. The group which can be examined is limited by the population of the prison for juvenile offenders and the explaining variables for “relapse” as “addicted to drugs” present non-metric scaling. For the explanation only probabilities for “relapse” can be indicated in this connection. By means of this probability it is possible to classify the individual case. The forecast is simulated by coincidental dividing of the data: the first part of the data is used for the explanation, the second for the forecast. With the comparison of the logistic regression with the neural nets, the superiority of neural nets in the explanation of “relapse” can be shown, since the neural nets are able to consider dependence between the explaining variables and according to that they offer a differentiated explanation. Their efficiency to predict “relapse” depends on the comparability of the distribution in the two coincidentally provided samples, the training data record for determining the explanation and the test case for the use of the explanation regarding the forecast. For optimal explanation and forecast neural nets are to be preferred to the logistic regression, since in the model with the better explanation also includes the potential for a usable better forecast. Moreover the model of the logistic regression is in fact a special case of the neural net, with a reduced complexity of the net.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(2):187-99.
Various methods of dynamic functional analysis in human sciences and economics].
Including the temporal and developmental dimension into the measurement of human conduct is a fundamental concern for those who do research in natural surroundings. Observing an individual day after day may possibly give a more complete vision of how behavior works than measuring a group of individuals at a single time and analyzing the differences found among them. Unfortunately most of the tools allowing analyzing individual time series call for large numbers of repeated observations. Thus, practicable longitudinal research designs often do not involve either enough repeated measurements for traditional time series analyses nor either replicate enough individuals for traditional, large-sample analyses. Dynamic factor analysis is a rationale and procedure for both pooling relatively short time series information across limited numbers of participants and analyzing the pooled information for its dynamic, process-relevant elements.
It is a merging of two important analytical tools – multivariate time series and the common factor model, from which it distinguishes itself mainly by the fact that in dynamic factor analysis, the values of the common factors can influence the values of the observed variables both concurrently and in delayed fashion.
Dynamic factor analysis is actually a method which allows detecting structures in the time series as well as the relations between the series and the explanatory variables. We illustrate the different models used in psychology and social sciences, as well as in econometry and economics.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(1):87-107.
History of psychiatric care.
The lecture incorporates stages of the Ettelbruck jubilee-hospital into european psychiatric history of the two last centuries. Beginning with social exclusion in the sense of a Michel Foucauld (“Central Hospice”), then turning into a typical large psychiatric hospital the CHNP is nowadays a specialized clinic with national tasks within the network of mental health community care. Milestones of this evolution are: the isolation theory of the 19th and beginning of the 20th centuries; eugenics and euthanasia on patients in Nazi-Germany; the second psychiatric revolution after World War 2 and it’s impact in Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(1):37-64.
Implications and details of the responsibility of radiologists in organized screening activities.
Demuth R, Hazebroucq V, Schwebag MM.
Medical responsibility in screening activities. In 1992 a national breast cancer screening programme was launched by the ministry of health in Luxembourg. This programme refers to the “European Guidelines for quality assurance in mammography”. This screening is non-centralised: the analog mammograms are performed in 9 Hospital radiology departments. The first reading is done in the hospital department by a radiologist. The mammograms are then sent to the Coordination Centre for encoding and a second reading. If needed, a decision is reached by consensus in a third reading. The Coordination Centre is in charge of tracking positive cases, follow-up of quality assurance, training and epidemiological evaluation of the programme. Radiologists and radiographers are requested to renew their certification on a regular basis. In the frame of elaborating guidelines for good practice for all participants, radiologists have organised a debate about the legal responsibility of radiologists who are participating as first or second readers. The same was done for radiographers, secretaries, hospital administrators and the staff of the Coordinating Centre.
This debate has brought together all radiologists and representatives of the ministry of health, comprising a legal adviser and an external expert acting for the Court of Paris, being himself a radiologist which specific medical training and activities in mammography. The main conclusion of this debate is the entire responsibility of the first reader in the frame of this medical activity, which is taking place under well specified predefined procedures.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(1):29-35.
Development of the medical treatment of diabetes in Luxembourg.
Perquin M, Keipes M, Wirion R, Haas N, de Beaufort CE, Michel GH.
OBJECTIVES: The aims of the study were to estimate the prevalence of diabetes in
Luxembourg in 2002, to compare it to the prevalence reported in 1991 and to evaluate if prescription attitudes have changed since 1991.
METHODS: The prevalence of diabetes was estimated using the drug sales data. The key parameters, total amount of antidiabetic drugs sold in one year and the average daily dose or Prescribed Daily Dose (PDD), have been obtained from the National Social Security Organization and by a standardized questionnaire sent to all general practitioners and all internists and endocrinologists of the country.
RESULTS: The PDD was calculated on 2,402 questionnaires on individual diabetic patients. By this mean, the proportion of patients only treated with appropriate diet could also be obtained. Compared to 1991, the total amount of antidiabetic drugs showed a four-fold increase in biguanides tablet prescriptions. A high percentage of combined treatments was found. The prevalence of diabetes in Luxembourg was found to be 3.05% of the total population.
CONCLUSIONS: Compared to the status in 1991, prevalence of diabetes increased by 63%, which seems mainly due to type 2 diabetic patients as orally-treated diabetic patients almost doubled (2.11% vs 1.16%). A substantial change in prescriptions for diabetes has occurred, suggesting a positive influence of studies like the United Kingdom Prospective Diabetes Study (UKPDS).
Bull Soc Sci Med Grand Duche Luxemb. 2006;(1):21-8.
Involvement of the RNAse L gene in prostate cancer.
Kieffer N, Schmitz M, Scheiden R, Nathan M, Faber JC.
Prostate cancer is one of the most common cancers among men and has long been recognized to occur in familial clusters. Identification of genetic susceptibility loci for prostate cancer has however been extremely difficult, and only in 1996 was the first prostate cancer susceptibility locus HPC1 mapped to chromosome 1q24-25. Since, several additional putative loci have been identified by genetic linkage analysis on chromosome 1, 17, 20 and X (reviewed in). For three of these loci, family-based studies have identified three genes associated with inherited prostate cancer: the 3′ processing endoribonuclease ELAC2/HPC2 gene, the macrophage scavenger receptor 1 gene (MSR1), and the endoribonuclease RNase L gene (RNAse L/HPC1). Here we will focus our review on the RNAse L gene and its involvement in prostate cancer and other diseases.
Bull Soc Sci Med Grand Duche Luxemb. 2006;(1):7-19.
Prescription of physical activity in cardiology: classical and new indications (a review based on evidence based data).
Delagardelle C, Feiereisen P.
Evidence based data of physical activity in primary prevention of coronary heart disease are excellent. For secondary prevention these data still are acceptable. Although it is an important new target group for physical therapy, there are so far no favourable data for exclusive training therapy in children or adolescents presenting a syndrome of obesity, sedentary lifestyle and bad nutrition. In nearly all the studies in this field physical activity is integrated in nutrition counselling and behavioural therapy. The following recommendations for public health can be made: Each adult should exercise at least half an hour and each child or adolescent one hour a day. Physical activity is the logical response to the sedentary lifestyle and hyper caloric food intake which are continuously spreading all over the world since 3 decades. It is an excellent therapy with nearly no side effects.
Bull Soc Sci Med Grand Duche Luxemb. 2005;(1):91-106.
Increase in the wealth of emergency patients at the Central Hospital of
Luxembourg. Who are they? Why do the come?.
Scheefer S, Mancuso G, Stein-Mergen M.
As in all European countries, the CHL’s Emergency Department is faced with a constant increase in the number of patients. The demographic patient profile in the 2001 survey shows a majority of young males with traumatic problems. Mostly evoked reasons for the increase are the lack of availability of general practitioners and patients’ low level of information about the competences of GPs. The article discusses possible solutions to the bottlenecks in Emergency
Bull Soc Sci Med Grand Duche Luxemb. 2005;(1):55-65.
Limitations and possibilities of applying the positive effects of human/animal relations in the treatment of psychological ailments.
Spautz JM, Otterstedt C, Kaiser M, Nocerini L, Bastian T, Mertens C, Degn B, Servais V, Tanner EF, Otterstedt C.
For the 72nd Psychiatric Saar-Lorr-Lux Symposium (Sept. 2004 at the
Neuropsychiatric Hospital (CHNP) in Ettelbruck, LUXEMBOURG), Dr. Jean-Marie Spautz, director, brought together professionals of varied disciplines, each involved in Animal Assisted Therapy (AAT).
Bull Soc Sci Med Grand Duche Luxemb. 2005;(1):23-53.
Alcohol, pharmaceuticals, illicit drugs and driving.
Wennig R, Origer A, Bour J, Pepin G, Maurer HH, Gillard C, Verstraete A, Maurer HJ, Willekens M.
A great number of clinical, epidemiological, pharmacological and toxicological data on the influence of psychotropics on driving are available. These psychotropics include psycholeptics like ethanol, opioids, psychoanaleptics like cocaine, amphetamines and congeners, psychodysleptics like cannabis, LSD and magic mushrooms. General epidemiology and specific epidemiology for Luxembourg will be outlined. Practical aspects of roadside testing, forensic aspects as well as the place of hair testing in drugs and road safety issues will be discussed.
Bull Soc Sci Med Grand Duche Luxemb. 2005;(1):7-22.
Hereditary spherocytosis is more frequent than expected: what to tell the
Modern double beam laser technique allows screening for hereditary spherocytosis in the course of routine hematology. An incidence of 1:150 men and 1:800 women has been determined. The anomaly is symptomless in the majority of the cases. This explains the discrepancy between our values and the incidence of 1:5,000 reported in the literature. The diagnosis of hereditary spherocytosis should be reported to the physician and the patient, as it may be wayleading in case of unexpected, unspecific complications such as anemia, jaundice, cholelithiasis, liver cell damage and iron overload. Regular monitoring of plasma ferritin and glucose is recommended.
Bull Soc Sci Med Grand Duche Luxemb. 2004;(2):159-72.
25 years of toxicology in Luxembourg, contributions by the National Health Laboratory.
A historical overview of the Institution and a retrospective of the most interesting works undertaken in the toxicology department as well as the methodology used in analytical clinical and forensic toxicology will be outlined. The main activities of the department are toxicological investigations of biological specimens of intoxicated patients as well as material involved in intoxication cases asked by sanitary and governmental authorities. Scientific research activities in the department as well as development and validation of analytical methodology will be reported.
Bull Soc Sci Med Grand Duche Luxemb. 2004;(2):109-19.
Dermatomyositis-like syndrome following acute toxoplasmosis.
Saberin A, Lutgen C, Humbel RL, Hentges F.
The case of a patient who developed an acute dermatomyositis-like syndrome upon infection by Toxoplasma gondii is reported. Emphasis is given on the chronology of the anti-Toxoplasma IgM and IgG antibody rise, the muscle enzyme movements, the antinuclear antibody development in comparison to the clinical symptoms and their follow-up after Toxoplasma treatment. The close monitoring of the sequential clinical and biological pattern allows insights into the infectious and auto-immune diseases presented by this patient. Taking into account other reported cases and the clinical presentation of this patient some conclusions and recommendations are inferred.
Bull Soc Sci Med Grand Duche Luxemb. 2003;(1):63-73.
50th anniversary of the Luxembourg Society of sports medicine.
Bull Soc Sci Med Grand Duche Luxemb. 2003;(1):35-7.
Luxembourg meeting for clinical and experimental virology. Luxembourg, 27.09.02.
Bull Soc Sci Med Grand Duche Luxemb. 2003;(1):23-34.
Beta3 integrins: major therapeutic targets of the near future.
Integrins are major cell adhesion receptors which assume two important functions: first they act as anchoring molecules allowing firm cellular attachment to the extracellular matrix, and second they work as signalling receptors being able to transduce signals in both directions (outside-in and inside-out) through the plasma membrane. Their biological importance is determined by their involvement in many physiological phenomena. Furthermore, their implication in various diseases and their accessibility to drugs make them interesting therapeutic targets.
Bull Soc Sci Med Grand Duche Luxemb. 2003;(1):17-22.
Puncture-lavage-infiltration of calcifying tendinitis of the rotator cuff.
Lasar Y, Azzolin J.
Calcifying tendinitis of rotator cuff is a common and evolutive pathology of the shoulder. This article supports the efficiency of imaging-guided needle puncture trituration and lavage in rotator cuff calcifications after failure of medical treatment. Overall efficiency of this economical ambulatory treatment ranges in the literature from 49 to 100 % and no complication is noted. In our opinion this technique should be used before arthroscopic or surgical removal of the calcifying tendinitis.
Bull Soc Sci Med Grand Duche Luxemb. 2003;(1):7-16.
Review of laparoscopic and open colorectal surgery in the “Zitha” Hospital(Luxembourg) in the year 2002.
Kayser J, Faber C, Bisdorff J, Bock C, Pescatore P, Reichling J, Sand J, Turk P.
BACKGROUND: A review and outcome of laparoscopic colorectal surgery in the visceral surgery unit in the Zitha Hospital for the year 2002.
METHODS: All patients, presenting with benign or malignant disease of the colon or rectum were evaluated. Depending on the tumour size, a laparoscopic approach is advocated whenever possible. Operation and patient specific factors (age, duration of the procedure and duration of hospital stay, diagnosis of malignant tumour versus benign disease, conversion and complication rate) are presented. Patients who had to be converted are classified under the open surgery group.
RESULTS: A total of 103 laparoscopic or open procedures on the colon/rectum were performed between the 1st of January 2002 and the 31st of December 2002. 74% were treated by a laparoscopic and 26% by an open approach. 10 out of 103 patients did not undergo a colonic resection but instead an emergency colostomy/ ileostomy or oversewing of a bowel leak, in 8 cases performed laparoscopically. 44 patients have been operated for a benign disease (36 laparoscopic and 8 open procedures) and 59 patients have been treated for a malignant disease (40 laparoscopic and 19 open procedures). The average operating time for the laparoscopic resection was 160 minutes in comparison to 182 minutes for the open resection. The conversion rate (inclusive of non-resection procedures) was 5% for a benign disease and 11% for colorectal cancer. The minor complication rate was 16% in laparoscopic surgery and 30% in open surgery. We saw two major complications in both the open and laparoscopic groups (4%). Reoperation was necessary in one patient out of 103. The average postoperative hospital stay was 7.78 days for the laparoscopic and 16.6 days for the open group. The hospital mortality was 2.9%.
CONCLUSION: The laparoscopic colorectal resection is a safe and beneficial procedure for the patient when used in experienced hands.
Bull Soc Sci Med Grand Duche Luxemb. 2003;(2):111-5.
Early detection of synchronous thyroid carcinoma and malignant melanoma by fluorodeoxyglucose positron emission tomography].
Snen M, Decker G, Lasar Y, Pilloy W, Berchem G.
Functional tumor imaging using Fluorodeoxyglucose positron emission tomography (FDG-PET) is a new method in clinical oncology. The 18 FDG, is a glucose analog that accumulates in cells in proportion to the rate of glucose metabolism, and increased carbohydrate metabolism has been recognized as a feature of malignant cells versus normal cells. In addition, it permits the detection of metastases or synchronous tumours not discovered by anatomic imaging. Although detection of the primary site of disease is usually accomplished well with conventional techniques, the performance of FDG-PET may be useful to determine tumours that are not clinically evident. The authors describe a case of early detection of synchronous thyroid carcinoma by FDG-PET in a young patient opereted on for a malignant melanoma on his arm.
Bull Soc Sci Med Grand Duche Luxemb. 2003;(2):97-109.
Radiotherapy at the Grand Duchy of Luxembourg.
Metzler F, Scheifer G, Untereiner M, Staudt H, Mecellem H, Triviere N,
Lassen-Ramshad Y, Ruchaud R, Joseph S.
The Centre François Baclesse was created as National Radiotherapy Center in 2000. Oncology Radiotherapy has been developed in Luxembourg in parallel with existing medical and surgical oncology departments. Cancer is a Public Health problem in Luxembourg. More than 1800 new cases of cancer are diagnosed every year, out of wich 70 % will need radiotherapy at the time of the evolution of the disease. Technical platform and Human Resources available at this time are able to deliver high quality treatment. The activity reached a plateau in 2002 with almost 800 patients treated per year, whereas the theorical need for radiation oncology treatment is 1200 patients per year in Luxembourg. A large architectural project will add 2 new linear accelerators and will be finished by 2007-2008. Multidisciplinary oncological network has been developed together with cancer treatment units of 6 luxembourgish hospitals. Clinical Research is one of the missions of the Center. After the achievement of its extension, the Centre François Baclesse will be able to cover the need of the Regional, Luxembourgish and cross-boarder patients pool, in line with an European approach in treating cancer.
Bull Soc Sci Med Grand Duche Luxemb. 2003;(2):87-96.
The impact of crisis intervention on the management of patients with personality disorder.
Damsa C, Di Clemente T, Massarczyk O, Haupert J, Pull C.
The aim of this study was to investigate in psychiatric emergency unit at Hospital Center of Luxembourg the impact of crisis intervention on the management of patients with personality disorder. There were included in this study all the patients with the diagnosis of personality disorder (axis II, criteria DSM IV), even the reason for emergency consultation was related to a disorder diagnosed on the axis I (criteria DSM IV). Data were retrospectively collected to compare patients examined in the psychiatric emergency unit during five months, from 1st September 2001 to 31st January 2002, with those examined from 1st September 2002 to 31st January 2003 and able to benefit from a crisis intervention. The results show a significant reduction of voluntary hospitalizations and a significant increase of the number of patients with more than five outpatient consultations, after the introduction of crisis interventions. The theoretical frame of our psychotherapeutic interventions is briefly exposed. The results of this study emphasize the importance of crisis interventions in psychiatry for improving the management of patients with a personality disorder.
Bull Soc Sci Med Grand Duche Luxemb. 2004;(1):33-9.
Evaluation of the national epidemiological program of breast cancer screening in the Grand Duchy of Luxembourg, 1999-2002.
Scharpantgen A, Lux C, Wagnon MC, Shannoun F, Schank JM, Back C, Brochmann C,Hansen-Koenig D.
In 1992 a national breast cancer screening programme was launched in Luxembourg with following characteristics; invitation at 2-yearly interval, 2 views, double reading for women aged between 50 and 64 and since 2001, those aged 65-69 are as well included. From the beginning on, one of the main concern was to respect a rigorous methodology, in accordance with the recommendations of the European Commission. This paper presents the early performance indicators of the years 1999-2002 of the “Programme Mammographie”. Almost all histopathological results were obtained, because only one national pathology laboratory exists inLuxembourg, where also the national tumor’s register is located. In ten years, a total of 91.432 mammograms were performed. The results of the early performance indicators are in agreement with the European Recommendations. A 36% detection rate of small size cancers, < or = 10 mm, and since 2000, more then 70% of node negative cancers are observed among women aged 50-64 attending the Programme. The cancer rate with a good prognostic factor for the patients is high. Despite good results, the rate of interval cancers is still too high, and two conclusions can be drown: the women’s participation at screening has to be steady in time without trespassing a two years intervals, and after the detection of small cancer a high quality assessment should be followed by an adequate treatment, leading to a reduction of mortality and also to a decrease of morbidity by treatment.
Bull Soc Sci Med Grand Duche Luxemb. 2004;(1):17-31.
Cerebral apoplexy–importance of diagnosis and therapy in acute stroke.
Droste DW, Metz R, Hoffmann M, Kruger M.
Every day occur about 4 strokes in the Grand-Duchy of Luxemburg. Stroke is the third cause of death and the first cause of acquired handicap. Stroke constitutes a major individual and social problem. Stroke and TIA are neurological emergency conditions that warrant immediate hospitalisation on a stroke unit, where a dedicated equipe of neurologists, nurses, speech and occupational therapists, physiotherapists and social workers in collaboration with other medical and surgical specialties provide up-to-date diagnostic and therapeutic measures.
These include the diagnostic work-up of stroke aetiology and the vascular status, monitoring to ensure the maintenance of homeostasis, thrombolysis and revascularisation, antithrombotic drug treatment relying on individual stroke pathophysiology, treatment of risk factors and early rehabilitation. By treatment on a stroke unit, death and disability can be reduced by 27%, in the case of intravenous thrombolysis even by 45%.
Bull Soc Sci Med Grand Duche Luxemb. 2004;(1):7-16.
Prevalence of transmission of methicillin resistant Staphylococcus in home care patients.
Gelhausen E, Arendt V, Kirpach P, Henrioulle C, Hemmer R.
Methicilline-resistant Staphylococcus aureus (MRSA) is among the most important causes of hospital-acquired infections. The aim of the present study was to investigate the prevalence of MRSA carriage among home care patients as well as among the health care personnel taking care of those patients. 93 patients and 30 staff members of the team of a home care sector in the western part of Luxembourg were screened for MRSA carriage and factors associated with carriage were investigated among the patients.
Bull Soc Sci Med Grand Duche Luxemb. 2002;(2):193-9.
Curiosities of past times. Women in medicine.
Elizabeth Blackwell was the first woman in modern times to get in 1849 a diploma as doctor in medicine in the United States of America. In the 1860th some women in England, France, Switzerland and Russia managed to become medical doctors. In Luxembourg it was only in 1922 that the first lady became a dentist and in the year after the first lady a generalist in medical practice. In 1925, Dr Fr. Delvaux from Luxembourg wrote a text about the “bad genius in the history of medicine”. In his mind the woman as a doctor was such a bad genius preventing progress in medicine. An excerpt of this text concerning woman in medicine is given here.
Bull Soc Sci Med Grand Duche Luxemb. 2002;(2):171-91.
Plan to combat European swine fever in wild pigs. Plan for Luxembourg.
Initially the different methods of fighting the Classical Swine Fever in the wild boar population in Belgium, France, Germany an Luxembourg will be examined in detail. Following this, each of the four national methods will be compared and discussed, so as to produce a method specific to Luxembourg. The time-scale will reach until October 2003.
Bull Soc Sci Med Grand Duche Luxemb. 2002;(2):121-34.
Treatment of pneumonia acquired in the community.
Waschbisch T, Schlesser M, Nati R.
The community-acquired pneumonia is a common and serious illness. Pneumonia is said to be community acquired if it is contracted outside of hospital environment or if it is diagnosed within the first 48 hours of hospitalisation. The pathogen remains unknown after investigations in around 50%. The patient should initially be treated empirically, based on the likely pathogens according to the patient’s risk-factors, underlying diseases, severity of pneumonia and place of therapy. If recent guidelines are compared (American Thoracic Society, British Thoracic
Society and the Infectious Disease Advisory Board) there are differences concerning epidemiology, patients classification and the empiric antibiotic treatment. The appearance of resistances and the recent availability of new antibiotics account partially for these differences. In order to avoid further resistances but still achieving an efficient treatment, coherent antibiotic schemes considering local microbiological epidemiology and patients classifications must be applied as proposed by different guidelines.
Bull Soc Sci Med Grand Duche Luxemb. 2002;(2):107-13.
Allergy to Ficus benjamina.
Karimian-Teherani D, Hentges F.
The clinical history of 16 patients found to have specific IgE antibodies against Ficus benjamina was analyzed in terms of allergic symptoms, clinical and biological cross-sensitisation to other allergens and compared to the data found in the literature. Two different groups of patients were studied. Group A consisted of 13 patients who became sensitised through contact with ficus plants and experienced symptoms upon exposure. Their main symptoms where conjunctivitis, rhinitis, asthma, eyelid oedema or urticaria. Of these patients 11 had other atopic manifestations. Two persons had no other allergy. 10 patients experienced symptoms at home, 2 at the working place and 1 while being in a restaurant. One patient had a crossreactive food allergy to figs. Group B consisted of 3 highly atopic patients who had also a sensitization both to latex (Hevea brasiliensis) and to Ficus benjamina. They had no clinical history of allergic reactions provoked by ficus plants.
Bull Soc Sci Med Grand Duche Luxemb. 2002;(1):73-5.
Meeting Report: the thyroid and brain. 5th Merck Thyroid Symposium Seville May 30-June 2, 2oo2.
Keipes M, Klees J.
Bull Soc Sci Med Grand Duche Luxemb. 2002;(1):35-59.
Meat inspection in the second half of the 19th Century, sign of progress in applied sciences.
Meat inspection as applied science was born in the second half of the 19th Century due to research on intestinal parasites that can be carried over to man by pigs and bovine animals as well as to the study of tuberculosis. It was only during that period that meat inspection was taken over by the veterinarians from expert-butchers. During the industrialization and demographic increase in the urban areas bringing about a great need of meat, a group of professionals denied that meat coming from sick animals and especially from those infected by tuberculosis represents a danger to the population. Epidemiology and bacterial examination finally allowed to solve this problems as well as the development of modern chilling techniques assured a better conservation of the meat. At the end of the 19th Century an important legislation about meat inspection appeared throughout Europe.
Bull Soc Sci Med Grand Duche Luxemb. 2002;(1):27-33.
Bioethics of the Portuguese integration in Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 2002;(1):7-11.
The treatment of assisted reproduction–clinical and preclinical aspects, functioning of the Unit of Human Reproduction at the Central Hospital of
Since a few years the OBGYN department at the Centre Hospitalier in Luxembourg has intensified its practice of ART with the introduction of a multidisciplinary team and a decentralized IVF program. While clinical investigations, cycle-monitoring and surgery, oocyte pick-up are commonly performed at the CHL, the biological supplement is transferred to next situated Belgian laboratories. As Luxembourg has no national bio-ethical law, we apply partly the French law of 1994.
Bull Soc Sci Med Grand Duche Luxemb. 2001;(1):7-15.
Quality evaluation of the orthodontic practice for certification by ISO 9001. A procedure beneficial for medical, medico-dental or hospital service.
The accreditation of the ISO 9001 certification (ISO = International Standard Organization) is an external evaluation procedure carried out by independent experts, whose object is the analysis of the operational methods and practices of a medical care facility (e.g. hospital, private clinic, general practitioner’s or dentist’s practice) which decided to assume the concept, implementation and control of its own quality policy. The whole accreditation procedure represents the basic structure of a continuous dynamic progressiveness within a cabinet eager to offer outstanding quality. Moreover, it guarantees active and voluntary participation of every single member of the medical administration or technical team involved in the realization of this primary objective. In other words, we are talking about a very strong dynamic innovation leading to a change of views and the improvement of communication means, while simultaneously enhancing the security and quality aspects of medical care. The continuous guarantee of high quality medical care calls for precise planning and systematization of actions. First of all, these actions are defined, analyzed and listed in precise work procedures. As they are defined with the agreement of the whole team, they implicate respect and self control. This requires of course transparency of the treatment methods, whose different steps and procedures are described in detail in a logogramm set up in common.
Bull Soc Sci Med Grand Duche Luxemb. 2001;(1):39-45.
A Merkel cell carcinoma of the skin.
Reiffers-Mettelock J, Ries F.
A 79-year old female caucasian patient presented in January 91 with a nodular lesion of the right cheek that had appeared rapidly. The histologic specimen was in favour of a primary neuroendocrine skin tumor, Merkel cell carcinoma-. In March 91, a relapsing nodule had grown up and adenopathies were found on the right parotid and sub-mandibular spaces. An aggressive polychemotherapy was performed for 6 cycles and a complete remission was obtained. In November 91 the sub-mandibular lymph node had reappeared. A complete staging was again performed. After 3 cycles of chemotherapy, a regional radiotherapy completed the treatment. With a follow-up of more than 8 years the patient stays in complete remission in
Bull Soc Sci Med Grand Duche Luxemb. 2001;(1):29-36.
Lipiwatch: a study of the treatment of dyslipidemias in Luxembourg.
Michel G, Wirion R, Keipes M, Scharpantgen R, Heger G; LIPIWATCH.
LIPIWATCH is an observational study which has been initiated for 6 months in
Belgium and in Luxembourg in 1997 to evaluate if patients treated by lipid-lowering drugs could reach the recommendations of the EAS and NCEP II for LDL-C. 76 patients (31 men) with a mean age of 59.2 +/- 11.39 years were included. 96% of patients had at least one other associated cardiovascular risk factor. After 6 months of treatment, 33% of all patients and only 30% of patients with coronary heart disease or peripheral vascular disease or at least 2 other risk factors reached the recommendations of the EAS. 25% of all patients and only 20% of patients with known coronary heart disease reached the NCEP II recommendations. 55% of patients had a statin prescribed and 38% a fibrate. Mean total cholesterol and mean LDL-C was lowered by 20% and 19% after 6 months. These disappointing results confirmed an insufficient awareness by physicians and patients, inadequate dosages of drugs and a bad compliance by patients.
Bull Soc Sci Med Grand Duche Luxemb. 2001;(1):17-27.
Economic assessment of iron deficiency. Replacement of ferritin and serum iron by other parameters.
Kutter D, Kremer A.
Economic assessment of iron deficiency. Replacement of serum iron and ferritin by other parameters. Serum iron and ferritin are still widely used parameters for the assessment of iron deficiency, in spite of their poor diagnostic performance. Compared to the combined use of ferritin, zinc protoporphyrin and soluble transferrin receptors an increase of the percentage of hypochromic erythrocytes (PEH) was found to be highly sensitive and specific for iron deficiency. We suggest to use it in a two phase strategy. Normal PEH excludes iron deficiency. Increased PEH may be confirmed by zinc protoporphyrin and/or soluble transferring receptors.
Bull Soc Sci Med Grand Duche Luxemb. 2000;(1):9-16.
15 years of exercise for cardiac patient in the Grand Duchy of Luxembourg: balance sheet and perspectives.
Bull Soc Sci Med Grand Duche Luxemb. 2000;(1):55-73.
History of aspirin in the Grand Duchy of Luxembourg.
Altzinger G, Reckel P.
Bull Soc Sci Med Grand Duche Luxemb. 2000;(1):31-8.
Sleep apnea syndromes and traffic accidents.
Schlesser M, Tiete J, Leyen P, Knauf-Hubel D, Nati R.
The sleep apnea syndrome (SAS) is an independent and important risk factor of traffic accidents. The risk is further increased by cofactors such as alcohol intake or poor visibility driving conditions. It is still difficult to prospectively identify apneic patients at forseeable driving risk; previous accidents, reaction tests, steering simulation tests as different polysomnographic parametres appear to be the most promising markers. The initiation of nocturnal nasal continuous positive airway pressure treatment (nCPAP) normalizes patient’s accident risk. Unfortunately there does not exist any accurate European nor national regulation dealing with issuing a driving licence for persons with sleep apnea disorder.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(4):65-9.
Integrated document management–key technology for successful undertakings and organizations in health services.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(4):55-6.
Date manipulation in the area of health services. The example of SAP R/3.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(4):49-54.
Significance of electronic security in health services in the German Republic.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(4):35-9.
Home care services in Luxembourg–innovative activity of the CPL Group.
[No authors listed]
Bull Soc Sci Med Grand Duche Luxemb. 1999;(4):33-4.
Fresenius Kabi “From product to home care service provider”.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(4):11-9.
Address of the Minister of Health and Social Security Carlo Wagner at the 10th International Congress CALASS (23 September 1999).
Bull Soc Sci Med Grand Duche Luxemb. 1999;(4):9-10.
“Health Forum”. “Overstepping the limits of efficient cooperation in the field of health systems”.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(3):97-104.
Risk management in an ambulatory surgery clinic.
The special conditions in ambulant surgery in hospital require a preventing risk management to reach a security for patients which is comparable to stationary therapy. These requirements will be outlined concisely. At the example of organisation of ambulant surgery at the Ilmtalklinik Pfaffenhofen (Germany) a system of risk management is described. There defined running offs and developed checklists and their relation to risk management will be represented. In meaning of the authors risk-management is an essential part of general quality management.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(3):91-6.
“Risk management in the practice field of ambulatory surgery in the intersectioof home and hospital practice”, with the practical example of the Ilmtal Clinic in Pfaffenhofen.
Caring for patients in out-patients departments with ambulant surgery requires new thinking, new organizational structures and administration in hospitals. Ilmtal-Clinic in Pfaffenhofen has designed a model system to facilitate procedures with a high standard and risk management.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(3):87-9.
The D10med patient clarification system.
Doctors have to inform their patients about their disease, the procedures and risks of the treatments which will follow. This information is an essential topic in risk-management of our health care systems. DIOmed has designed over 500 checklists in different languages and for different medical treatments. These sheets facilitate the procedure and guarantee a high quality of information.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(3):41-51.
Risk management in gynecology and obstetrics. Forensic questions in connection with operative gynecology and obstetrics.
Scharf A, Steinborn A, Geka F, Sohn C.
Due to the avalanche-like increase of malpractice suits, it has become mandatory for doctors in hospitals and private practices to acquire a profound knowledge relating to modern management and to become familiar with the legal aspects of medical procedures. The article at hand reviews the standards of medical documentation and risk information within the scope of operative gynaecology and obstetrics and provides guidelines for a structured behaviour once an incident has occurred. The typical sources of complications are presented and strategies to avoid them are outlined: professional clinical management including the definition of competences for all therapists working together in a hospital. By observing these principles a professional medical level even in administrative respect is provided and thus enables an atmosphere of mutual confidence among doctors and patients.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(3):35-40.
The place of arbitration agencies in practice.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(3):27-34.
Professional incompetence: significance, definition, cost investigation.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(3):23-5.
Personal risk management: private services for the aged.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(3):17-21.
Medical liability insurance. Risk management from the view of the insurance.
Vellguth J, Dettmer J, Schweitzer D.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(2):73-81.
External quality assurance in heart surgery at INCCI at the St Elizabeth Clinic using the modified Cleveland Scores].
Wendt G, Bourg NP.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(2):59-71.
[Recurrent abortion. Etiology and occurrence].
Van Linthout C, Ahrendt J.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(2):45-57.
Diagnosis of lung cancer.
Schlesser M, Berchem GJ, Nati R.
Due to the frequent diagnosis at a late inoperable stage and the bad prognosis of metastatic disease, lung cancer has become the first cause of cancer mortality. Early detection is thus the only way to influence mortality as there is no good treatment available for advanced disease. In the eighties, large screening studies using standard chest X Ray and sputum cytology have not been able to show a significant reduction in global lung cancer mortality. However these studies are now largely criticized for their methodological flaws. Recently, a new technique using auto-fluorescence fibroscopy has been developed, which is able to detect dysplastic and in situ neoplastic lesions which are invisible to standard fibroscopic techniques. This technique holds great promise in the detection of early lesions. In addition, molecular biology techniques are being developed which aim at detecting early invasive lesions at a stage where surgical treatment is still curative. The addition of these two techniques will probably in the future increase the efficiency of lung cancer screening. Therefore we think that new large scale screening studies are needed.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(2):37-43.
Cholesterol embolism: an often unknown disease; a report of two cases.
Rauh S, Simon M, Harf C, Welter R, Duhoux P.
We report on a case of post-invasive acute renal insufficiency and a case of acute necrotizing pancreatitis, both histologically proven to have been caused by cholesterol embolisms. A survey of the literature with discussion of diagnostic
and therapeutic options is given.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(2):29-36.
Complications and hospitalisation–duration after chemoembolisation for liver metastases.
Rauh S, Duhem C, Ries F, Dicato M.
In a retrospective study, all patients of the hemato-oncology department of the Centre Hospitalier who were treated from 1988 to 1997 by chemoembolisation for liver metastases were analysed for treatment-related hospitalisation duration, side effects and complications, in order to assess the treatment burden. Major side-effects were: pain in 17 of 29 patients, nausea in 8, vomiting in 7, persistent hickup in 3, fever in 12, a temporary confusional state in 4 patients. 1 patient experienced syncope, 2 patients developed homolateral pleral effusions, 1 patient suffered transient supraventricular arrhythmias. Major complications included 1 hemoperitoneum (under anticoagulant therapy), 1 hemorrhagic gastritis, 1 acute cholecystitis due to inflammatory tumoral choledochal obstruction and one iatrogenous acute pancreatic ischemic necrosis. Two patients died of post-embolic acute hepatic insufficiency, one 10 days, one 41 days after the last treatment session). In summary, chemo-embolisation of liver metastases is a complication-burdened treatment in a strictly palliative setting with inestimable efficacy. The treatment modalities have to be discussed with the patient beforehand and preferably in controlled study setting. Large randomised trials may indicate patients’ subgroups for benefit.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(2):24-8.
“The twilight of the gods” (of neurology).
Bull Soc Sci Med Grand Duche Luxemb. 1999;(1):103-22.
Science and medicine in 18th Century Luxembourg.
During the 18th century science and medicine are poorly developed in Luxembourg (present part of the former duchy). Leprosy is vanishing and black death belongs to the past, whereas dysentery, typhoid fever and other epidemical diseases are thriving. In some specific diseases people claim help from protective saints such as St. Hubert (rabies) and St. Willibrord or the Blessed Virgin Mary. Besides these aspects the paper gives a concise outline of the situation in Luxembourg during the 18th century concerning hospitals, physicians, pharmacists and popular medicine.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(1):96-101.
Dragon’s blood. A glance into the history of pharmacognosy.
Dragon’s blood, a red resin, which is often used as a dry powdered “herbal” remedy in traditional medicine, has different origins which are briefly discussed. This contribution however focuses on the species of the genus Dracaena Vand ex L., belonging to the Agavaceae and native to the Old World and the Canary Islands. H.J.N. Crantz, a botanist and medical doctor turned pharmacologist (born in 1722 near Luxembourg), had published a brief and very uncommon treatise on this group of plants, which he only knew from botanical gardens. The pharmacognostical and historical background of dragon’s blood use is at the core of this contribution–the drug itself being of no major importance in today’s medical care.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(1):74-95.
De duabus draconis arboribus botanicorum.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(1):65-73.
Selenum carvifolia versus Peucedanum carfifolia. An historical look back on a botanical review and the first observation of the botanical work of H.J.N.Crantz.
The case history of Peucedanum carvifolia Vill. and Selinum carvifolia L.
(Apiaceae/Umbelliferae) is on one hand the occasion for a first attempt of a historical review of H.J.N. Crantz’s (1722-1797) publications on the
Umbelliferae, and on the other hand the opportunity for a discussion of the taxonomical and nomenclatural peculiarities of both species.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(1):45-63.
Animal nutrition in the dietetics of the 18th Century with “Materiae Medicae” by H.J.N. Crantz as an example.
H.J.N. Crantz (1722-1797), a physician and botanist born in the Duchy of
Luxembourg and practising in Vienna under the Empress Maria Theresia during the 18th century, deals in his “materiae medicae et chirurgicae”, written in Latin language, also with animal foodstuff. Animals from various species are commented on the utility of their meat and products to maintain health or to recover it after illness. The items of the text are described in free translation and in summary. Some more explanations are added.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(1):41-3.
H.J.N. Crantz. His rank, its origin and significance.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(1):23-39.
“Climate of knowledge, professional career and outside interests” using H.J.N. Crantz (1722-1797) as an example.
Bull Soc Sci Med Grand Duche Luxemb. 1999;(1):19-21.
“Crantz” from the “Biographie Luxembourgeoise” (“Luxembourg Biographies”).
[No authors listed]
Bull Soc Sci Med Grand Duche Luxemb. 1999;(1):15-8.
“Cranz” from “Das Gelehrte Osterreich” (“The Scholary Austrian”).
[No authors listed]
Bull Soc Sci Med Grand Duche Luxemb. 1999;(1):10-3.
Who am “I”? An essay on the dubious nature of the curriculum vitae.
198. Bull Soc Sci Med Grand Duche Luxemb. 1998;135(1):51-8.
The threat of premature labor: new aspects for management.
Wertz JP, Frising M, Arendt J.
Genital inflammation may play a major role in the pathogenesis of preterm labor. Screening and early treatment of subclinical genital tract infections (bacterial vaginosis, heavy group B streptococci colonization, primary genital HSV infection and other silent intra-uterine infections) seem to offer promise for the prevention of preterm labor. New factors have been studied in order to appreciate their benefit in the evaluation of the risk of preterm labor. None of these biologic markers (fetal-fibronectin, maternal interleukin-6, vaginal pH measuring) have enough sensitivity to permit efficient screening. Home uterine activity monitoring seems to be interesting for early identification of women with increased risk of preterm delivery, but can’t be used on a large scale because of its costs. New tocolytic agents are investigated in order to protect from an adverse outcome. Atosiban exhibits more oxytocin selective and antagonistic activity without side-effects, and nimesulide seems to have a lack of effects on fetal functions.
Bull Soc Sci Med Grand Duche Luxemb. 1998;135(1):43-50.
Results of field studies using Stellamune mycoplasma vaccine in Luxembourg.
Enzootic pneumonia caused by Mycoplasma hyopneumoniae is responsible for major economic losses in pig herds worldwide. M. hyopneumoniae can also act as a primary agent of swine respiratory disease followed by bacterial or viral infections. Vaccines have been developed to prevent enzootic pneumoniae. In this experiment, an inactivated vaccine against mycoplasma, also sold under the name Stellamune mycoplasma (Pfizer Animal Health) was used in 2 farms with a known history of M. hyopneumoniae infection. The objective of the study was to evaluate the effect of the product on lung lesions caused by M. hyopneumoniae and on economic performance of the pigs under field conditions.
200. Bull Soc Sci Med Grand Duche Luxemb. 1998;135(1):39-42.
Spontaneous regression of pulmonary metastases in renal cancer.
Rauh S, Duhem C, Ries F, Dicato M, Lamy S, Lens V.
Spontaneous regression of lung-metastases in kidney cancer (a case report) A case is reported of a 56-year old woman with renal cell carcinoma operated and treated adjuvantly for a year with Interferon alpha. Ten months thereafter the patient had histologically proven a large pulmonary metastatic disease that regressed spontaneously. Duration of the spontaneous remission was 8 months.
Bull Soc Sci Med Grand Duche Luxemb. 1998;135(1):11-23.
Prostatic cancer in the Grand Duchy of Luxembourg. Role of PSA.
Lamy S, Hein T, Wilmart JF, Capesius C, Scheiden R, Gilson G, Humbel RL.
We reviewed the trends in prostate cancer incidence and mortality in Luxembourg between 1983 and 1995 to discuss the importance of total and free PSA in early detection. The study was performed on all the new cases recorded by the National Cancer Registry (Registre Morphologique des Tumeurs). Total and free PSA were measured with the automated Immulite System (DPC, Los Angeles) using a chemoluminescent immunometric assay. The performance of free-to-total serum PSA was analysed by a hospital based study of 113 patients (55 PC, 58 BPH). The age standardized incidence rate increased from 29.3/100,000 in 1983 to 71.5/100,000 in 1995. Mortality rates only changed slightly. The widespread use of PSA testing from 1988 on is probably the main cause of this incidental increase; however no major changes in the age-specific-incidence have been found suggesting the absence of a systematic screening policy by the PSA. The superiority of free-to-total serum PSA ratio in discriminating between cancer and benign condition was confirmed. Early health-conscious man over 50 should be proposed prostate cancer screening by digital rectal examination and PSA. However a systematic screening policy cannot been recommended since a benefit in survival after early treatment has not yet been proven.
Bull Soc Sci Med Grand Duche Luxemb. 1997;134(2):43-9.
Will we all be poisoned?.
Since several years there is a great concern in the general population, that all people will be poisoned by food additives, drug and pesticide residues in food and by environmental pollution. There is a great confusion about the real risk due to these issues. The author tries to explain these misunderstandings by some typical examples. Toxicity testing procedures used for the evaluation of chemical safety are enumerated. Misinterpretation of experimental studies and epidemiology
studies are at the origin of these fears. Except for acute industrial accidents, suicide attempts and drug abuse the risk of poisoning is rather low. Often the excellent performances of modern analytical technologies are at the origin of many incorrect conclusions. The concept of acceptable daily intake, safety factors, relative risks of deaths and other safety issues are discussed.
Bull Soc Sci Med Grand Duche Luxemb. 1997;134(2):27-30.
Adenosarcoma and other uterine sarcomas.
Schindler S, Gratia P, Müllenberger G, Arendt J.
Sarcomas are tumors of conjunctive origin, rarely relating to the gynaecological sphere; among these, the adenosarcoma only represent one particular aspect. From one clinical case and from literature, the authors attempt to sum up the situation on the different clinical, para-clinical and therapeutic aspects of those bad-know neoplasia.
Bull Soc Sci Med Grand Duche Luxemb. 1997;134(2):17-22.
Factor V Leiden and thrombophilia.
Mahassen P, Dicato M.
Bull Soc Sci Med Grand Duche Luxemb. 1997;134(2):11-5.
The neuropathies of IgM monoclonal gammopathies.
Humbel RL, Schmit P, Gilson G.
A peripheral polyneuropathy is often associated with an IgM monoclonal
gammapathy. The monoclonal protein often binds to carbohydrate epitopes on glycoproteins and/or glycolipids of the human peripheral nerve. The clinical syndrome is related to the antigen-specificity of the IgM protein. Detection of anti-myelin antibodies and further characterization of their immunogenic specificity provide an important aid in the differential diagnosis of late-onset chronic polyneuropathies.
Bull Soc Sci Med Grand Duche Luxemb. 1997;134(1):9-12.
Injectable phenytoin: problems of stability in solution.
Francés A, García Martí A, Bruck M.
Because of its efficient antiseizure activity, intravenous phenytoin remains a major agent in acute therapy, although it is associated with many pharmacokinetical and toxicological problems. This contribution focuses on the difficulties in finding the appropriate mode of intravenous administration, a matter which is of considerable clinical importance. The fact that precipitations of phenytoin occur when the product is incorrectly diluted is common knowledge–yet the pharmacy department is frequently contacted because of an improper handling of the products available. A review of the factors contributing to precipitation problems, the i.v. products in use in the Grand-Duchy of Luxembourg and the possible i.v. dilutions for these products are discussed.
Bull Soc Sci Med Grand Duche Luxemb. 1997;134(1):31-51.
Smallpox: an historical review.
The first protection against smallpox, a disease known already in old China and India, consisted in rubbing infectious material from smallpox patients into the scratched skin of children. Lady Montagu brought this method from Turkey to England in 1721. This “variolation”, however dangerous, was adopted in Europe during the eighteenth century mainly by the aristocracy. But it was Edward Jenner (1749-1823) who in 1796 used cowpox to protect against smallpox without the risk of acquiring the disease. During more than 60 years the “vaccination” was carried
out from “arm to arm” with a certain risk of transmission of syphilis. From 1864 on the vaccine was mainly produced on cows to avoid this risk. The WHO managed in 1978 to eliminate smallpox from the planet by vaccination. The smallpox outbreaks, the inoculation, the vaccination and the production of cowpox vaccine in Luxembourg are described.
Bull Soc Sci Med Grand Duche Luxemb. 1997;134(1):25-9.
Prenatal serum screening of aneuploidy and of neural tube defects in the second trimester of pregnancy among the population of Luxembourg. Evaluation of risk by the triple test (AFP+THCG+UE3).
AIM: The value of the antenatal maternal serum screening by triple test during second trimester pregnancy has been examined for the Luxembourg population.
SUBJECT: In collaboration with the gynaecologists using our triple test, the performance of the screening has been evaluated against the outcome (before and at birth) of all the pregnancies screened between end of 1991 and 28.02.1996. In particular, the effectiveness of Down’s syndrome (Trisomy-21) detection has been ascertained.
RESULTS: A total of 6760 pregnancies has been screened. Women’s age ranged from 16 to 44 years, with a mean age of 28.4 years, 5.68% had > or = 35 years. The screening has been positive (at higher risk) for 7.25% pregnancies, wherein 5.98% were at higher risk for Trisomy-21 and 1.27% at higher risk for Neural Tube Defects (NTD). Among the screen positives, 20.79% were aged > or = 35 years and 79.21% were < 35 ans. There have been 12 Down’s cases present among the 6760 pregnancies, 9 of them had in the screening a calculated risk higher than the cut-off (1:250). The detection rate (sensitivity) for Trisomy-21 was 75%, the specificity was 94.15% and the predictive value of a positive test was 2.23%.
CONCLUSION: This study shows that our antenatal maternal serum screening compares favorably with the other screenings realized by reference centres and the results produced are reliable.
Bull Soc Sci Med Grand Duche Luxemb. 1997;134(1):21-4.
New diagnostic approaches to deep venous thrombosis.
Rauh S, Dicato M, Duhem C, Ries F.
This review summarizes a number of recent articles reconsidering the use of phlebography as the golden standard for deep venous thrombosis. Compression ultrasound and color-coded duplex doppler seem to be reasonably sensitive to provide safety in detecting lower limb thrombosis while less invasive. A clinical risk factor panel may further enhance diagnostic security.
Bull Soc Sci Med Grand Duche Luxemb. 1997;134(1):5-8.
Radiological diagnosis and therapy of pulmonary arteriovenous fistulae in a patient with an atypical clinical history: a case report.
Debaere C, Lens V, Hermes G, Kurdziel JC.
Pulmonary arteriovenous fistulae were first managed nonsurgically by Porstmann in 1977 with homemade metallic coils (1). During the intervening twenty years better catheterization techniques have been developed and our understanding of the clinical outcomings of these lesions has improved. This report discusses the natural history of pulmonary arteriovenous fistulae, including the neurological and other complications, the importance of family screening in the detection of
asymptomatic family members, the diagnostic strategy and the description of improved techniques for embolotherapy with stainless steel coils.
Bull Soc Sci Med Grand Duche Luxemb. 1996;133(2):5-12.
Prevention of sudden death in Luxembourg.
Caeymaex L, Schroell M.
Bull Soc Sci Med Grand Duche Luxemb. 1996;133(2):27-33.
Immunophenotyping in the diagnosis of non-Hodgkin lymphomas: a literature review.
Rauh S, Duhem C, Mahassen P, Ries F, Dicato M.
Bull Soc Sci Med Grand Duche Luxemb. 1996;133(2):13-25.
The health care system of the Grand Duchy of Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 1996;133(1):43-6.
Peculiarities from the past: ABC of rural medical practice.
Bull Soc Sci Med Grand Duche Luxemb. 1996;133(1):25-9.
Clinical study enabling improvement of inpatient psychotherapeutic treatment and after care of patients admitted in a specialized center.
Bull Soc Sci Med Grand Duche Luxemb. 1996;133(1):13-24.
Autoantibodies in nervous system diseases.
Humbel RL, Schmit P, Gilson G.
Bull Soc Sci Med Grand Duche Luxemb. 1996;133(1):5-12.
MHC-genotyping of IDDM patients in Luxembourg. Evidence for a pediatric patient subgroup.
Hentges FR, Michel GH, Hoffmann AJ, De Beaufort CE, Thill RR, Wirion RP, Thill MJ, Glaesener GM.
Bull Soc Sci Med Grand Duche Luxemb. 1995;132(3):43-7.
Drug monitoring in the Grand Duchy of Luxembourg and in the European Community in 1995.
Bull Soc Sci Med Grand Duche Luxemb. 1995;132(3):19-26.
Resistance to chemotherapy: current therapeutic approach.
Ries F, Pauly M, Poeckes L, Duhem C, Dicato M.
Bull Soc Sci Med Grand Duche Luxemb. 1995;132(2):67-8.
The role of Mondorf in the European context.
Bull Soc Sci Med Grand Duche Luxemb. 1995;132(2):33-40.
In-situ hybridization in the detection of trisomy 12 in chronic lymphatic leukemia.
Duhem C, Poeckes E, Molitor P, Heintz D, Ries F, Dicato M.
Bull Soc Sci Med Grand Duche Luxemb. 1995;132(2):17-20.
Type B Haemophilus influenzae infections. Experience at the Pediatric Hospital of Luxembourg.
De Jonghe M, Glaesener G.
We have made a retrospective study of invasive Hib infections which have occurred in the Children’s Hospital since 1980 to the end of July 1994; and we have been able to notice that since the introduction of vaccination against Hib, especially since it is free, the incidence of invasive Hib infections in the Grand Duchy of Luxembourg is in great decline.
Bull Soc Sci Med Grand Duche Luxemb. 1994;131(1):7-11.
“Liewen Dobaussen”, an example of deinstitutionalization for nonpsychotic patients.
De Smet Y.
Bull Soc Sci Med Grand Duche Luxemb. 1994;131(1):49-58.
Pharmacology and clinical drug research in 18th-century Vienna.
“The history of medication and early clinical pharmacological research in Vienna in the 18th century” is starting on a broad summary of nearly two millenniums of medical therapy and “materia medica”. Commencing with the antique Hippocratic school and progressing in a rapid overview of the most important and commonly known facts on medication and therapy, this contribution leads into a more extensive investigation trying to emphasize the importance of the so-called “First Viennese Medical School” and the scientific works of two Viennese medical doctors originated from Luxemburg, H. J. Crantz and H. J. Collin, in the investigation and propagation of new remedies and the progress of therapy.
Bull Soc Sci Med Grand Duche Luxemb. 1994;131(1):39-48.
Apoptosis and cancer.
Duhem C, Ries F, Dicato M.
Bull Soc Sci Med Grand Duche Luxemb. 1994;131(1):31-7.
Pregnancy toxemia. Current aspects, therapy and literature review.
Bull Soc Sci Med Grand Duche Luxemb. 1994;131(1):17-30.
Implantable insulin pumps: evaluation after more than 3 years experience.
Keipes M, Michel G, Pinget M.
Since the beginning of insulin therapy the improvement of treatment in IDDM is mainly for acute metabolic complications than for chronic degenerative complications. The DCCT could recently prove for the first time that the incidence of chronic complications (retinopathy, nephropathy and neuropathy)could be diminished by reaching glycemic control in more than 700 patients. One of the problems explaining the failure of classical treatment is due to the variability of absorption in the sub-cutaneous tissue. The patients treated by insulin pumps are all IDDM. The aim of this study is to evaluate safety and feasibility of implantable programmable pumps with intraperitoneal insulin infusion. We found three cases of irreversible catheter obstruction. Defects of external communicators and the slow-downs of insulin infusion in infusaid pumps were observed. No acceleration in insulin infusion was found. Acute metabolic complications were two severe hypoglycemic events, but no acito-cetosis. After more than two years for most of the patients we observed a global improvement in glycemic control, demonstrated by a better mean glycemia and lower HbA1c values. The standard deviation of the glycemia was lowered significantly, this value reflects daily fluctuability. The number of hypoglycemias was also lowered. Our
study shows a more stable glycemic control than the one in the DCCT study. The safety and feasibility seem to be highly satisfying.
Bull Soc Sci Med Grand Duche Luxemb. 1994;131(1):13-6.
Hastert F, Moscariello A, Arendt V, Beissel J, Pesch C, Delagardelle C.
Bull Soc Sci Med Grand Duche Luxemb. 1994;131(2):9-17.
Production and characterization of monoclonal antibodies directed against high and low molecular weight kininogens.
Hentges F, Kohnen M, Grigioni F, Reichert P, Humbel R, Schneider F.
HMWK and LMWK were purified from human plasma by ion exchange and affinity chromatography and used to raise anti-kininogen monoclonal antibodies. The Ig class and affinity of these Mab’s that are directed at the heavy chain of the kininogens, were determined. Plasma samples of two patients, one with acquired C1-inhibitor deficiency and angioedema and one with idiopathic angioedema were analized by immunoblotting with these Mab’s. Both were found to have cleaved HMWK during clinical attacks.
Bull Soc Sci Med Grand Duche Luxemb. 1994;131(2):5-8.
Severe neutropenia in infectious mononucleosis.
Duhem C, Ries F, Dicato M.
Bull Soc Sci Med Grand Duche Luxemb. 1994;131(2):31-4.
Coexistence of 2 distinct populations of neutrophil granulocytes, one totally, the other partially deficient in myeloperoxidase.
Kutter D, Niedner A, Lieners C.
Bull Soc Sci Med Grand Duche Luxemb. 1994;131(2):25-9.
Indications for and limitations of vaginal hysterectomy.
Bull Soc Sci Med Grand Duche Luxemb. 1994;131(2):19-23.
De Jonghe M, Schroell M, Degremont-Weitzel C.
Joubert’s syndrome is clinically characterized by attacks of tachypnea
alternating with respiratory pauses, abnormal ocular movements, psychomotor retardation, and ataxia. Anatomic anomalies include cerebellar vermis agenesis with dilatation of the fourth ventricle. It is an autosomal recessive disorder; onset is in the neonatal period and prognosis is severe.
Bull Soc Sci Med Grand Duche Luxemb. 1993;130(1):61-3.
Doctors’ attitudes towards patients who smoke and opinions on the role of the medical profession in policies to control tobacco use.
Schneider JC, Adriaanse HP.
Bull Soc Sci Med Grand Duche Luxemb. 1993;130(1):57-60.
Theophylline and seizures.
Moscariello A, Jacob F, Harf C, Welter R.
Bull Soc Sci Med Grand Duche Luxemb. 1993;130(1):5-9.
Chemoprevention: a new strategy in the fight against breast cancer?.
Berchem G, Ries F, Dicato M.
Bull Soc Sci Med Grand Duche Luxemb. 1993;130(1):45-56.
The first 7 months of activities in a psychogeriatric unit in Luxembourg.
Since September 1991 a new unity has been opened in the Neuro-Psychiatric
Hospital: a ward of 26 beds for psychogeriatric patients. 50 persons (half women and half men) have been admitted during the first seven months. By the end of this study (June 1992) 76% are no more staying in the hospital. Besides the five deaths, most of the people have returned to their previous home. With a mean stay of two to three months we believe that our psychogeriatric ward will be able to admit about 70 or 80 new patients by one year.
248. Bull Soc Sci Med Grand Duche Luxemb. 1993;130(1):37-43.
Heat shock proteins.
All cells, procaryotic and eucaryotic, respond to a rise in environmental
temperature by a rapid synthesis of a set of specific proteins: the heat shock proteins (HSPs). These HSPs appear to be among the most conserved proteins in nature and certain members of the HSP family are present in non-stressed cells.
These observations are reflecting the fact that HSPs serve vital physiological functions as well in normal cells as in stressed cells. In the past few years, various fields of medicine have shown growing interest in the role that the HSPs may play in cellular mechanisms. In this paper we are briefly summarizing the actual knowledge of HSP involvement in carcinogenic and immunological processes.
Bull Soc Sci Med Grand Duche Luxemb. 1993;130(1):25-36.
Fetal and adrenal transplantation in Parkinson disease: theoretical bases and clinical results.
Diederich NJ, Goetz CG.
Bull Soc Sci Med Grand Duche Luxemb. 1992;129(2):5-10.
National scheme of external evaluation of the quality of clinical biological analyses.
Hansen G, Schartz M.
Bull Soc Sci Med Grand Duche Luxemb. 1992;129(2):31-5.
Launois-Bensaude disease: the value of preoperative facialembolization and combination surgery-lipoaspiration. Apropos of 2 case reports.
Sainte-Rose G, Serrière N, Calteux N.
Bull Soc Sci Med Grand Duche Luxemb. 1992;129(2):25-9.
Thrombopenia secondary to heparin.
Le Moine F, Meyer S, Ries F, Dicato M.
Bull Soc Sci Med Grand Duche Luxemb. 1990;127(1):9-13.
Fractures of the odontoid process: osteosynthesis using direct screwing.
Dang PT, Roilgen A, Mailliet JP.
Bull Soc Sci Med Grand Duche Luxemb. 1990;127(1):45-9.
Cysticercosis of the 4th ventricle.
Sandt G, Beissel L, Roilgen A.
Bull Soc Sci Med Grand Duche Luxemb. 1990;127(1):41-3.
Camembert, Listeria and the immunocompromised patient.
Ries F, Dicato M, Hemmer R, Arendt F.
Listeriosis is a rare but well known infectious complication in pregnant women and immunocompromised patients. Epidemiological studies have shown an association between listeriosis and alimentary contamination by listeria of a variety of foodstuff including soft, ripened cheeses. We describe two case-reports of listeria meningitis with high evidence of food-related illness due to the consumption of contaminated camembert. These observations urged our State Department of Health to formulate a communication about alimentary listeriosis at the intent of all health care professionals, including recommendations for patients at risk.
Bull Soc Sci Med Grand Duche Luxemb. 1990;127(1):35-9.
An epidemiological study of hypercholesterolemia in the Grand Duchy of
Michel G, Bouckaert A.
Epidemiology of hypercholesterolemia in the Grand Duchy of Luxembourg was studied by the mean of a questionnaire filled out by 17 physicians. 113 patients (50 men and 63 women) were recruited. 43 patients had an isolated hypercholesterolemia(type IIa) and 63 patients had a type IIb. Analysis of associated risk factors showed large variations (13.2% of patients had diabetes, 61% were sedentary).
However, 33.5% of patients had at least one associated risk factor. The
nutritional assessment showed the well-known dietary errors. A two month’s treatment with ciprofibrate has shown a 20% decrease of total cholesterol and a 32% decrease of triglycerides. No serious adverse events were reported.
Bull Soc Sci Med Grand Duche Luxemb. 1990;127(1):29-33.
Meyer S, Ries F, Dicato M.
Bull Soc Sci Med Grand Duche Luxemb. 1990;127(1):23-7.
A case control study of cigarette smoking and lung cancer in Luxembourg.
Mahon GA, Dicato MA, Ries F, Muller R, Sand J, Scheiffer G, Hansen-Koenig D,Margue C.
Bull Soc Sci Med Grand Duche Luxemb. 1990;127(1):15-21.
Aluminum in hemodialysis.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:93-4.
The Sacré-Coeur Hospital.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:9-25.
The Bulletin de la Société des Sciences médicales du Grand-Duché de Luxembourg,from its origins til our days (1864-1989).
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:85-91.
Contribution of the Sisters of Ste. Elisabeth to the care of patients and to social welfare in the past 150 years.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:81-3.
Various problems in mental health from the perspective of the Hospital for Neuropsychiatry.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:77-80.
The National Laboratory of Health.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:71-5.
The medical school from 1818 to 1988.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:63-9.
History of dental medicine in Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:39-61.
Veterinary chronicle. The Luxembourg veterinarian from 1790 till our days.
Theves G, Kremer J.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:33-8.
History of the medical society of the Grand Duchy of Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:27-32.
From the past of Luxembourg medicine: citation from Dr. Franz Delvaux.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:113-22.
History of the Ste-Thérèse Hospital from its beginnings till today.
Welter E Jr.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:109-12.
Chronicle of the Eich Hospital.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:101-7.
The Hospital Center of Luxembourg, a nearly successful experience.
Bull Soc Sci Med Grand Duche Luxemb. 1989;Spec No:1-129.
Jubilee number for the 125th anniversary of the Society for Medical Sciences of Luxembourg.
[No authors listed]
Bull Soc Sci Med Grand Duche Luxemb. 1986;123(2):57-9.
Determination of hormone receptors in cancer of the breast. Presentation of 5-year results in Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 1986;123(2):117-28.
Present status of pneumology.
Schneider JC, Parini JP.
Bull Soc Sci Med Grand Duche Luxemb. 1986;123(2):103-10.
Burgdorfer’s borreliosis or Lyme disease. The first Luxembourg cases.
Reiffers-Mettelock J, Glaesener G, Schroell M.
Bull Soc Sci Med Grand Duche Luxemb. 1985;122(1):11-7.
Frequency of congenital abnormalities in the Grand Duchy of Luxembourg. Apropos of 7015 births occurring from 1980 to 1982.
Hansen-Koenig D, De Wals P.
Bull Soc Sci Med Grand Duche Luxemb. 1984;121(1):13-22.
Intestinal eukaryotic parasites in Luxembourg–decline, eradication and future perspectives.
Fox E, Liesch C, Schneider F.
Bull Soc Sci Med Grand Duche Luxemb. 1984;121(2):39-52.
History of toxicology in Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 1983;120(2):31-6.
Socioeconomic factors intervening in the treatment of alcoholics. A description of the therapeutic sequence.
Bull Soc Sci Med Grand Duche Luxemb. 1983;120(1):43-9.
Possible correlations of principle parameters in alcoholics: apropos of 100 cases in Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 1982;119(2):35-49.
Psychodiagnosis of alcoholism in Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 1981;118(2):29-32.
Therapeutic Center of Useldange. Appreciation of the therapeutic efficiency of the Center over a period of 2 years.
Bull Soc Sci Med Grand Duche Luxemb. 1981;118(1):73-87.
Management of scoliosis with vertebral traction.
Sienne G, Cotrel Y, de la Caffiniere JY.
Bull Soc Sci Med Grand Duche Luxemb. 1981;118(1):61-71.
Results of 10 years’ detection of scoliosis organized in the Grand Duchy of Luxembourg.
Konsbruck R, Cotrel Y.
Bull Soc Sci Med Grand Duche Luxemb. 1981;118(1):53-60.
Health policies regarding the problem of scoliosis in the Grand Duchy of
Bull Soc Sci Med Grand Duche Luxemb. 1981;118(2):23-7.
2 years’ experience with laboratory of chemical toxicology and pharmacology in the framework of emergency toxicology in Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 1980;117(2):3-10.
The Therapeutic Center of Useldange. A specialized treatment service for
alcoholics: report of 1979 activities.
Bull Soc Sci Med Grand Duche Luxemb. 1979;116(2):225-9.
Survey of medical periodicals in Luxembourg.
Klincker J, Dicato M.
Bull Soc Sci Med Grand Duche Luxemb. 1979;116(2):205-15.
Survey on smoking in students.
Bull Soc Sci Med Grand Duche Luxemb. 1978;115(2):89-97.
Alcoholism in the Grand Duchy of Luxembourg. Statistical data and organization of a specialized treatment service.
Bull Soc Sci Med Grand Duche Luxemb. 1972 Oct;109(2):187-96.
Ergonomic research in the siderurgy of Luxembourg.
Foehr R, Vogt JJ.
Bull Soc Sci Med Grand Duche Luxemb. 1971 Oct;108(2):163.
Tribute to Doctor René Koltz.
Bull Soc Sci Med Grand Duche Luxemb. 1969 Mar;106(1):9-48.
Perinatal infant mortality at the Maternite Grande-Duchesse Charlotte,
Luxembourg. Analytic, critical and comparative study of obstetrical service from 1956 to 1967.
Bull Soc Sci Med Grand Duche Luxemb. 1968 Nov;105(2):9-33.
Rabies in the Grand Duchy of Luxembourg.
Kohn A, Maar L.
Bull Soc Sci Med Grand Duche Luxemb. 1968 Nov;105(2):5-6.
Neuen J: [In memory of Doctor Pierre Felten].
Bull Soc Sci Med Grand Duche Luxemb. 1968 Nov;105(2):51-9.
Anti-D feto-maternal immunization and its prevention.
Bull Soc Sci Med Grand Duche Luxemb. 1966 Nov;103(2):1-260.
“The human factor in relation to safety.” Study of the practical value, in the prevention of work accidents, of clinical, biological and psychometric tests in the iron industry of Luxembourg.
Muller G, Noesen R, Putz C, Rauchs A, Robert A, De Bisschop G, Hamus P, Hoffmann A.
Bull Soc Sci Med Grand Duche Luxemb. 1965 Nov;102(3):305-16.
Occupational deafness in Luxembourg.
334. Bull Soc Sci Med Grand Duche Luxemb. 1965 Jun;102(2):261-5.
Study on rehabilitation-reeducation.
Heintz N, Koltz R, Noesen R, Thyes A, Wolter E.
335. Bull Soc Sci Med Grand Duche Luxemb. 1965 Jun;102(2):243-50.
Critical report on the prosthetic equipment for the extremities.
Bull Soc Sci Med Grand Duche Luxemb. 1965 Jun;102(2):223-32.
The vocational rehabilitation of patients with stabilized pulmonary tuberculosis in the Centre de Gondreville.
Cahen G, Wagner E, Boisseau J.
Bull Soc Sci Med Grand Duche Luxemb. 1965 Jun;102(2):191-202.
The pyrogenous shock by magnesium in polygraphical recordings.
Mosinger M, Noesen R, de Bisschop G.
Bull Soc Sci Med Grand Duche Luxemb. 1965 Jun;102(2):145-64.
The service of respiratory reeducation and physiotherapy at Mondorf-Les-Bains.
Bull Soc Sci Med Grand Duche Luxemb. 1965 Jun;102(2):137-43.
Report on the creation of respiratory reeducation in the center for physical rehabilitation at Mondorf-Les-Bains].
Noesen R, Hostert A.
Bull Soc Sci Med Grand Duche Luxemb. 1965 Mar;102:67-102.
A CONDITIONED DEFICIENCY IN COPPER IN THE RUMINANTS IN THE INDUSTRIAL ZONE OF THE SOUTH OF THE GRAND DUCHY OF LUXEMBOURG.
BIENFET V, LOMBA F, CHAUVAUX G, FUMIERRE I, GOTTAL C, KOHN A.
Bull Soc Sci Med Grand Duche Luxemb. 1964 Nov;101:299-302.
NECROBACILLOSIS OF THE LIVER FOUND IN CATTLE IN THE GRAND DUCHY OF LUXEMBOURG.
GOTTAL C, KOHN A.
Bull Soc Sci Med Grand Duche Luxemb. 1964 Mar;101:35-8.
ON THE ANTIGENIC RELATIONSHIP BETWEEN CORYNEBACTERIUM OVIS AND BACTERIA OF THE BRUCELLA GROUP. APROPOS OF 2 CASES OBSERVED IN THE GRAND DUCHY OF LUXEMBOURG.
Bull Soc Sci Med Grand Duche Luxemb. 1964 Mar;101:21-30.
THE ADJUSTMENT OF HEARING AIDS IN LUXEMBOURG. STUDY CARRIED OUT ACCORDING TO DATA GATHERED IN THE AUDIOMETRY CENTER FROM 1958 TO 1963.
FABER E, BOHLER J.
Bull Soc Sci Med Grand Duche Luxemb. 1963 Oct;100:369-73.
POLIOMYELITIS IN ESCH-SUR-ALZETTE IN 1963.
MOLITOR L, RISCHARD CE.
Bull Soc Sci Med Grand Duche Luxemb. 1963 Jun;100:161-73.
Reflections on extra-hospital psychiatric assistance and applications in the Grand Duchy of Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 1963 Mar;100:7-11.
ACUTE MESENTERIC ADENITIS CAUSED BY PASTEURELLA PSEUDOTUBERCULOSIS. WITH REGARD TO 3 CASES DIAGNOSED IN LUXEMBOURG.
Bull Soc Sci Med Grand Duche Luxemb. 1963 Mar;100:69-101.
CONTRIBUTION TO THE HISTORY OF THE NATIONAL BACTERIOLOGICAL LABORATORY.
Bull Soc Sci Med Grand Duche Luxemb. 1963 Mar;100:39-41.
THE RESPONSIBILITY OF THE PHARMACIST AND DRUG CONTROL.
Bull Soc Sci Med Grand Duche Luxemb. 1961 Oct;98:599-629.
Methodical and analytical table of subjects contained in the Bulletin de la Societe des Sciences Medicales du Grand-Duche de Luxembourg from 1864 to 1961 inclusively.
Bull Soc Sci Med Grand Duche Luxemb. 1959 Mar;96(1):7-12.
Two cases of meningitis caused by Listeria monocytogenes in Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 1957 Dec;50:83-90.
Medical applications of radioisotopes in Luxembourg medical practice.
Bulletin, index par sujet de 1864-1963
1. Santé publique – Statistique
v. a. les Nos 159, 186, 189, 190, 480, 538.)
109 PUENDEL, Léon: Essai sur la réorganisation du Service sanitaire du Grand-Duché de Luxembourg. – 1921, 83-130. 3 tabl.
110 FONCK, G(ustave) : Übersicht der Sterbefälle, Gebuten und Trauungen in der Gemeinde Luxembourg während des Jahres 1876… – 1877, 91-92.
111 FONCK, G(ustave) : Öffentliche Gesundheitspflege. Sterblicjkeitsverhältnisse der Stadt Luxembourg im Jahre 1878, statistisch zusammengestellt. – 1879, 121-122.
112 RAPPORTS et documents se rattachant à la question de la constatation des décès recuillis par la Commission nommée le 29 octobre 1898. (Annexes. La constatation des décès dans les autres pays. France, Belgique, Angleterre, Autriche, Allemagne.) – 1899, Supplément, 3-73.
2. La profession
(v. a. les Nos 417, 503, 572.)
113 DISPOSITIONS législatives et administratives concernant l’art de guérir dans le Grand-Duché de 1882-1899. – 1899, 53-84.
114 PROJET de loi sur l’exercice de l’art de guérir. – 1901, 1-29.
115 PROJET de loi sur l’organisation et les attributions du Collège médical. – 1901, 31-60.
116 FABER, Aug(uste) : Considérations sur le projet de loi sur l ‘organisation et les attributions du Collège Médical présentées à l ‘assemblée de juillet de la Société des Sciences médicales. – 1901, 113-123.
117 CHAMBRE des Députés. Session législative de 1900-1901. Projet de lois sur l’exercice de l’art de guérir. Rapport de l Section centrale. – 1901, 125-133.
118 CHAMBRE des Députés. Session législative de 1900-1901. Projet de loi concernant l’organisation et les attributions du Collège médical. Rapport de la Section centrale. – 1901, 135-139.
119 DISPOSITIONS législatives et administratives concernant l’art de guérir dans le Grand-Duché de 1900 à 1901. – 1901, 201-232.
120 DELVAUX, Fr(ançois) : ‘T ass en âlen Dokter, dén elei schwätzt. – Décembre 1948, 87-102.
121 DUREN, S. : Les carrières médicales au Congo belge. Conférence. – Juin 1949, 105-115.
122 LOUTSCH, H(enri) : La collation des grandes en médecine. Lettre du Dr H. Loutsch, président de la Société des Sciences médicales, à Monsieur le ministre de l ‘Education nationale. – Juin 1949, 199-122.
123 WELTER, Eloi : A propos du nouveau Centre médico-pédagogique. – Juin 1950, 73-77.
124 KOLTZ, René : Note préliminaire sur l’institution d’un ordre des médecins du Grand-Duché de Luxembourg. – Juin 1950, 107-113.
125 VONCKEN, J. : L’état actuel de la législation médicale internationale. – Juin 1951, 7-25.
126 PUNDEL, J(ean)-Paul : A propos de la loi luxembourgeoise sur la collation des grandes en médecine – Février 1953, 111-116.
127 SCHAUS, Raymond : The changing trends of medecine. – Novembre 1958, 107-109.
128 WORRE, Félix : Le fichier international des médecins. – 1960, No 1, 123-124.
3. Hôpitaux – Laboratoires
(v. a. le No. 189.)
129 DISPOSITIONS concernant le fonctionnement du Laboratoire pratique de bactériologie de l’Etat à Luxembourg. – 1897, XXXIII – XXXIX.
130 LECLERE, Prosper : Rapport sur la construction et l’organisation d’un nouvel hôpital pour les membres de la Caisse de secours de la Société anonyme des Hauts-Fourneaux et Forges de Dudelange. – 1901, 185-199. 2 pl.
131 PRAUM, (Auguste) : Le Laboratoire pratique et bactériologique du Grand-Duché de Luxembourg. – 1917, 1-18. Fig.
132 FELTGEN, Ernest : Rôle particulier des dispensaires antituberculeux. Février 1940, 13-15.
133 WEISS, J(ean)-P(ierre) : Neuere Arbeitsmethoden im klinischen Laboratorium- – Décembre 1948, 71-75 ; Juin 1950, 63-70.
134 SCHMIT, P(ierre) : Notice sur le Comité central luxembourgeois de secours aus militaires blessés. – 1870, 111-116.
135 SCHMIT, P(ierre) : Œuvre de la Croix-Rouge. Rapport sur les services rendus par le Corps médical luxembourgeois dans la guerre de 1870 à 1871. – 1871, 1- 43.
136 URBANY, (Albert) et Prosper LECLERE : Verwaltung des Luxemburgischen Roten Kreuzes. Bericht über die Behandlung und Verpflegung der verwundeten Offiziere und Soldaten in den Spitälern der <<ARBED>> in Düdelingen. – 1917, 19-25.
137 WEBER, A(uguste) et (Guillaume) SCHOLTES : Verwaltung des Luxemburgischen Roten Kreuzes. Bericht über das Wirken, die Behandlung und Verpflegung der verwundeten Offiziere und Soldaten im Spital der <<ARBED>> in Beggen. – 1917, 27-31.
138 FABER, Jean : La mission du Corps médical luxembourgeois pendant la guerre. Rapport présenté à l ‘Assemblée générale de la Société des Sciences médicales du 8 octobre 1939. – Février 1940, 7-12.
(v. a. les Nos 472, 644.)
139 KOCH, Paul : De la voix humaine. – 1874, 139-176. 4 fig.
140 DELVAUX, François : Glossen zur Frage der künstlichen Befruchtung beim Menschen. – Décembre 1950, 93-102.
Radiobiologie – Radioactivité et Isotopes
v. a. les Nos 85, 153, 198..
141 KIOES, Camille : A propos du danger des radiations ionisantes. – 1961, No 1, 147-154. (Bibliographie de 43 titres.)
142 RISCHARD, Charles-Edouard et Paul KAYSER : A propos du danger des radiations ionisantes. – 1061, No 3. (Bibliogr. De 8 titres.)
143 SCHAUS, Raymond : Le traitement par les isotopes radioactifs en médecine interne. – 1957, No 1, 53-56.
144 RESPONSABILITE (La) du Corps médical dans l’emploi des rayons X et autres rayonnements ionisants. – Décembre 1957, (No 3), 67-72.
145 SCHAUS, Raymond : Un cours du British Council : Radioactiv(e) isotopes in medecine. – Décembre 1957, (No 3), 75-79.
146 SCHAUS, Raymond : Les applications médicales des isotopes radioactifs dans la perspective luxembourgeoise. – Décembre 1957, (No3), 83-90.
147 ENGEL , Robert : Le contrôle de ka radioactivité atmosphérique et des eaux de pluie au Centre nucléaire des Saclay. – 1959, No 3, 331-337. 2 fig.
VII. METHODES DE LA MEDECINE
Radiologie – Radiographie Radiodiagnostic – Radiothérapie et Electrothérapie
(v. a. les Nos 280, 330, 337, 338, 366, 386, 466, 469, 496, 499.)
148 GOERENS, Paul : Examens radiologiques en série dans le Grand-Duché. – Mai 1948, 70-74.
149 Hertz, Simon : Intérêt de la baryte épaisse dans l’examen radiologique de l’estomac. – Décembre 1950, 11-15. 2 pl.
150 DEMOULLIN, M(athias) : Hernie diaphragmatique et éventration diaphragmatique. – Mars 1954, 55-60.
151 PAULY, (Norbert) : Heilung von Magenschwüren durch Röntgentherapie. – 1917, 63-65.
152 THIBEAU, André : Intérêt de la radiothérapie pré-opératoire dans le traitement du cancer du sein, du larynx des sarcomes osseux etc. Conférence du Docteur BACLESSE… – 1959, No 3, 347-350.
153 KIOES, Camille : L’utilisation de l’idole radioactif dans les maladies de la thyroïde. I. Diagnostic. II. Thérapie. – 1960, No 2, 161-166. 4 fig. ; No 3, 277-283. (Bibliogr. De 34 titres.)
VIII. LES DIFFERENTES DISCIPLINES
1. Médecine interne
(v. a. le No 143.)
a) Maladies infectieuses
v- a. les numéros 72, 92, 132, 148, 281, 378, 381, 396, 402, 403, 408, 482-487, 508, 536, 556.)
154 FELTGEN, (Jean) : Über einige seltenere Verlaufsformen des Ileotyphus und die Wichtigkeit des Ileocoecalgeräusches als diagnostisches Zeichen bei dieser Krankheit. – 1864, 22-32.
155 SCHMIT, (Pierre) : Etude sur le choléra épidémique. – 1865, 1-26. (Bibliogr. Marginale.)
156 Bivort, J(ean) – B(aptiste) – A(lbert) : Observations et études sur les causes, la prophylaxie et le traitement de la fièvre typhoïde dans les communes rurales, suivies de considérations nouvelles sur la nature de cette maladie. – 1867, 13-87. (Bibliogr. D. l. t.),
157 FONCK, G(ustave) : Cholera und Morbus miliaris. Eine medizinische Skizze. – 1867, 122-120. (Bibliogr. Marginale.)
158 BIVORT, (Jean-Baptiste-Albert, Jean) FELTGEN, (Pierre)
SCHMIT : Rapport sur les épidémies de choléra et de suette qui ont sévi dans le Grand-Duché de Luxembourg pendant les années 1865 et 1866, fait à la Société… par la commission nommée par elle dans le but d’étudier ces épidémies… – 1868, 1-314, ill.
159 BIVORT, J(ean) – B(aptiste) – A(lbert) : Statistique et histoire des épidémies de choléra et de suette qui ont sévi pendant les années 1865 et 1866 dans la ville et les communes du district de Luxembourg. – 1868, 5-63. 6 tabl.
160 FELTGEN, (Jean) : Rapport sur les épidémies de choléra dans le district de Mersch en 1866. – 1868, 65-104. tabl.
161 SCHMIT, (Pierre) : Le choléra dans le district de Diekirch en 1866. – 1868, 105-124. 2 tabl.
162 ROEBE, (Victor) de : Renseignements sur la marche du choléra dans le district de Grevenmacher en 1866. – 1868, 125-130. 3 tabl.
163 BIVORT, j(ean) – B(aptiste) – A(lbert) : Considérations générales sur l’épidémie cholérique qui a sévi en 1865 et 1866 dans le Grand-Duché de Luxembourg. – 1868, 131-314. 3 cartes h.-t. (Bibliogr. D. l. t.)
164 BUFFET, (Adolphe-Nicolas) : A propos d’une épidémie de dysenterie dans la commune d’Asselborn. – 1869. 46-81.
165 FELTGEN, (Jean) : Contagium, Miasma, Parasitismus. – 1869, 82-100. (Bibliogr. Marginale.)
167 PICARD, Lambert-A. : Observations sur l’épidémie de fièvre jaune à Montevideo pendant l’année 1873. – 1874, 209-212.
168ARENS, Ed(ouard) : Beobachtung und Bemerkungen über die im Jahre 1870-1871 in Weiswampach grassierende Thyphusepidemie. – 1879, 95-104.
169 LEHNERTS, (Jean-Pierre) : Observation d’un cas d’hydrophobie rabique chez un homme de 49 ans. – 1882, 1-8.
170 MEYERS, J(ean) : Pocken und Schutzpocken in Esch an der Alzette (1881-82). – 1882, 96-115.
171 FELTGEN, (Jean) : Erysipelas und Puerperalfieber. – 1886, 113-124.
172 SIEGEN, Ch(arles) : L’actinomycose au point de vue de l’alimentation publique. – 1886, 213-222.
173 WELTER, (Michel) : Allgemenes über Infectionskrankheiten. Eine Studie. – 1890, 89-118.
174 WELTER, M(ichel) : Etude sur le choléra asiatique dans le Grand-Duché de Luxembourg (en 1854 et de 1865 à 1866). – 1893, 40-64.
175 PUENDEL, Leo : Ein aetiologisch und prognostisch intressanter Typhus_blutstuhl. – 1897, 151-155.
176 FELTGEN, Ernest : Beitrag zur Lehre über die Incubationszeit bei Tetanus traumaticus. – 1899, 29-31.
177 LECLERE, Prosper : Etudes sur la peste faites à l’Institut Pasteur en septembre 1900. – 1901, 145-157. (Bibliogr. De 3 titres.)
178 PUENDEL, Leo : Die Typhusepidemie Wormeldinfen von 1899. – 1901, 169-183. 1 fig.
179 PAULY, (Norbert) : Eine neue Behandlungsmethode von Echinokokkuserkrankung. – 1917, 49-56.
180 LOUTSCH, (Henri) : La vaccination antitétanique. – Mai 1939, 26-32.
FELTGEN, Ernest : Contributions à l’histoire de la pathologie et de la thérapie du mal tuberculeux. – Mai 1939, 38-43.
182 SCHERER, (Eugène) : A propos d’un cas de tuberculose du larynx. – Mai 1939, 50-53. 4 fig.
183 FABER, Jean : Le traitement des septicémies à streptocoques. – Février 1940, 41-48.
184 HARPES, Jean : La peste au Luxembourg. – Mai 1948, 79-87 ; Décembre 1948, 105-119.
185 HARPES, Jean : Un cas d’aspergillose pulmonaire. – Juin 1949, 57-61. 2 fig. (Bibliogr. De 8 titres.)
186 KOLTZ, René : La tuberculose pulmonaire au Grand-Duché de Luxembourg de 1945 à 1949. – Juin 1950, 80-94. 9 tabl.
187 NORGAARD: Die Tuberkulose in Dänemark und ihre Bekämpfung. – Décembre 1950, 83-87.
188 HIPPERT, Frédéric: Considérations statistiques et pratiques sur les maladies du groupe typhoparatyphique. – Juin 1951, 49- 52.
189 HOSTERT, Arsène: Résultats immédiats du traitement de la tuberculose pulmonaire ouverte en milieu sanatorial. Années 1946- 1951. Etude statistique de 180 cas. – Février 1953, 73-89. 12 tabl. [ Bibliogr. de 3 titres.]
190 HOSTE.RT, A[rsène]: Etude statistique de 160 cas d’aspiration endocavitaire. – Mars 1954, 63- 70. [Bibliogr. de 16 titres.]
191 NE PAS CONFONDRE : Méningo-encéphalite et poliomyélite. Une étude publiée par l’OMS met en lumière une nouvelle maladie à virus. – 1957, N° I, 47- 49.
192 VANBREUSEGHEM, R.: Les mycoses dans la pratique médicale quotidienne. – Décembre 1957, (No 3), 9-18. (Bibliogr. de 11 titres)
193 MOLITOR, Léon: A propos de la rage. – 1959, No 1, 69-71. (Bibliogr. de 5 titres.)
194 ORGANISATION moniale de la Santé: La variole en Europe. 1959, No 1, 125.
195 CANDAU, G.: L’eradication du paludisme: Un défi au monde. Jusqu’à la découverte du demier cas. – 1960, N° 2, 211-214.
b) Hématologie (v. a. les Nos 183, 260.)
196 SCHAUS, Raymond: Le stade silencieux des leucémies chroniques. – Juin 1958, 21-32. [Bibliogr. de 19 titres.]
197 HUART, Francois d’: La fibrinolyse en chirurgie. – 1960, N° 3, 369-388. 3 fig.
198 KIOES, Camille: Utilisation du Phosphore 32 dans les polyglobulies et les leucémies chroniques. – 1961, N° 3
c) Circulation – Coeur – Vaisseaux
(v. a. les Nos 87, 226, 249, 293, 428.)
199 WELTER, M[ichel]: Un cas d’asphyxie locale (Raynaud). – 1893, 25-29. [Bibliogr. de 5 titres.]
200 DELVAUX, Léon: Considérations sur la symptomatologie de l’anévrysme disséquant de l’aorte. – Décembre 1948, 35-43.
201 PUNDEL, [Jean-]Paul: La prophylaxie et le traitement des thromboses et embolies postopératoires par les anticoagulants. – Juin 1949, 65-75.
202 STEICHEN, F[élicien]: Des complications de l’aortographie. – Juin 1958, 9-16. [Bibliogr. de 15 titres.]
203 SCHAUS, Raymond: Un syndrome de perturbation électrolytique. – Juin 1958, 51-52.
204 SCHAUS, Raymond: La cardiopathie de la maladie de Friedreich. – Novembre 1958, 31- 43. 4 fig. [Bibliogr. de 16 titres.]
205 STORCK, L. et H. METZGER: Au sujet de troubles électrocardiographiques observés dans un cas d’intoxication barbiturique. – Novembre 1958, 97-103. 2 fig. h.-t. [Bibliogr. de 12 titres.]
206 DYRBYE, Martin 0.: The mucopolysaccharides in the aging of human arterial tissue. – 1959, N° 1, 75-77. [Bibliogr. de 20 titres.]
207 SCHAUS, Raymond: Le rétrécissement mitral. I. Mise au point générale. II. Présentation d’une observation. III. Les souffles diastoliques chez les mitraux. – 1959, N° 2, 207-216; N° 3, 311-315; 1960, N° 2, 185-189. [Bibliogr. de 15 titres.]
208 NATIONAL Health Education Committee. – Artériosclérose. – 1960, N° 3, 391-395.
209 METZ Henri: Les maladies cérébrovasculaires à la lumière des acquisitions récentes. – 1961, N° 1, 75-82. [Bibliogr. de 18 titres.]
210 CUNY, Gérard: Le traitement par les anticoagulants dans les accidents vasculaires cérébraux. – 1961, N° 1, 85-92. 3 tabl.
211 COMEL, Mario: Phlébologie et histangéiologie dans le cadre de l’angéiologie générale. – 1961, N° 2, 215-225. 5 tabl.
212 HURIEZ, Claude: Données tirées de l’étude de 1785 ulcères hospitalisés à la Clinique dermatologique universitaire de Lille de 1943 a 1959. – 1961, N° 2, 235- 237.
213 DE LANGEN, Cornelis D.: L’éffet de l’adrénaline sur les communications artérioveineuses périphériques. – 1961, N° 2, 239- 241.
214 BIRGER, Inge: Constatations anatomiques au cours de la chirurgie des varices. – 1961, N° 2, 243- 246.
215 VAN LIMBORGH, Jan, Dorita A. BANGA, Cornelis J. H. MEIJERINK et Johannes H. H. LUIGIES: Démonstration d’un modèle anatomique des veines de l’extrémité inférieure. – 1961, N° 2, 247-254, 4 fig.
216 MAES, Ernest: De l’opportunité d’une nomenclature international des veines du member inférieur. – 1961, No 2, 257-258.
217 SCHOOP, Werner: La stase veineuse et la circulation sanguine périphérique. – 196, No 2, 261-265. 4 fig.
218 HAID, Helmut et Freya HAID-FISCHER: Le diagnostic des inflammations veineuses aiguës du member inférieur et la valeur thérapeutique de la compression élastique de Fischer. – 1961, No 2, 269-277. 26 fig.
219 REINHAREZ, Didier: Les troubles circulatoires causes par le bruit. Incidences vasculaires du syndrome traumato-vibratoire. – 1961, No 2, 281-286.
220 ECKSTEIN, Harry: Les indications de la resection des veines profondes du member inférieur. – 1961, No 2, 289-293.
221 OOSTERHUIS, Koenraad: La possibilité de regeneration de la paroi veineuse. – 1961, No 2, 295-298.
222 VAN DER STRICHT, Jean P., Maurice GOLDSTEIN, Patrick VANDERHOEFT, Sabine GODARD, Jacques LITVINE et Albert FENKENBERG: Varices de jambs. Etat actuel de la question à la lumière de notre experience personnelle. – 1961, No 2, 301-312.
223 IMMINK, Eduard A. M.: Remarques sur la chirurgie veineuse. – 1961, No 2, 315-320. 7 fig.
224 GROSS, Dieter: La pathogénie de la douleur dans les affections veineuses des membres inférieurs. – 1961, No 2, 323-324.
225 SCHAUS, Raymond: Considérations pratiques sur l’hypertension artérielle diastolique et sur son traitement. – 1961, No 3. (Bibliogr. de 91 titres.)
d) Appareil digestif – Métabolisme
(v. a. les Nos 149-151, 260, 298, 351, 354, 356, 358, 359, 361, 363, 487, 628, 634.)
226 SCHMIT, (Pierre): Etude sur les hydropisies en general et plus spécialement sur leur pathogénie et leur traitement. – 1869, 13-45.)
227 FONCK, G(ustave): Hepatitis acuta mit Übergang in Abcessbildung. Heilung. – 1873, 31-33.
228 FELTGEN, J(ean): Leber-Abcess in Folge von Gallensteinen. – Durchbruch des Abcesses und Abgang der Steine nach Aussen. – Heilung. – 1873, 35-39).
229 SCHMIT, (Pierre): Diabète. – 1877, 11-12.
230 FABER, (Auguste): Ein Fall von recidivirender Speichelsteine. – 1893, 20-24.
231 BOEWER, Jean et Paul KOCH: Corps étranger de l’oesophage. – 1893, 79-82.
232 BUFFER, Lucien: Zur Casuistik der intestinalen Autointoxications-Psychosen. – 1897, 1-11.
233 KROMBACH, Wilhelm: Über eine Cholecystotomie wegen Hydrops vesicae fellae. – 1899, 37-44.
234 DELVAUX, Fr(ançois): Zur operative Behandlung der kompletten Mastdarmfisteln. – 1909, 259-262. (Bibliogr. de 2 titres.)
235 PAULY, (Norbert): Künstlicher Pylorusverschluss bei Gastroenterostomie. – 1917, 57-61.
236 PAULY, (Norbert): Ileus chronicus durch Inkarzeration des Dünndarms über einem Strang. – 1917, 71-74. 1 fig.
237 LOUTSCH, H(enri): A propos de deux cas de rétécissement cardio-oesophagien, traits par l’opération de Heller. – Août 1938, 83-89. 4 fig.
238 SENEQUE, J(ean): Les troubles secondaires consécutifs à la gastro-entérostomie. Conférence le 12 mars 1939… – Mai 1939, 18-25.
239 FABER, Jean: Volumineux ,,Calcul d’obstruction’’ du canal cystique. – Mai 1939, 47-49. 2 fig.
240 REILES, Mathias: A propos de trois cas de péritonites post-abortum. — Mai 1948. 23-30.
241 MEYERS, Hubert: Uber die Pankreatitis. – Mai 1948, 49-54.
242 HERTZ, Simon: Les hépatites dues au sérum humain (Homologous serum jaundice. – Décembre 1948, 21-32.
243 HIPPERT, Fréd[éric]: Cirrhose hépatique hypertrophique pigmentaire simple. – Décembre 1948, 45-47.
244 MALLET-GUY, Pierre: Les dystonies biliaires. – Juin 1949, 7-17.
245 STAHL, J. et Ch[arles] MAURER: Aspects actuels de la thérapeutique diététique des cirrhoses. – Juin 1949, 19-41. 7 fig. 5 tab!. [Bibliogr. de 17 titres.]
246 PAULY, Norbert et Simon HERTZ: Le problème diagnostique et thérapeutique de l’ulcère gastrique. – Juin 1950, 7-13. 2 illustr.
247 HIPPERT, Frédéric: Sur un cas d’hépatomégalie infantile isolée. – Décembre 1950, 23-25.
248 MUGLER, A.: La goutte viscérale, existe-t-elle? – Juin 1951, 53-57. [Bibliogr. de 5 titres.]
249 LOUTSCH, H[enri]: Les manifestations cardiaques des cholécystites. – Février 1953, 7-29. nombr. fig. [Bibliogr. de 29 titres.]
250 HERTZ, Simon: Sur un cas de sténose congénitale de l’oesophage. – Février 1953, 33-36. 1 fig.
251 HUART, Francois d’: L’occlusion intestinale. – Février 1953, 39- 60.
252 HUART, Francois d’: L’importance de la radiomanométrie biliaire peropératoire dans la chirurgie de la voie biliaire principale. – Fevrier 1953, 63-70.
253 WEINACHT, Daniel et Raymond DUPUY: Etude de l’acidité gastrique sans tubage. – 1956, N° 2, 127-134. [Bibliogr. de 10 titres.]
254 LOUTSCH, Henri: Quelques réflexions au sujet d’un cas de rétrécissement cicatriciel de l’oeso-phage. – 1956, N° 3, 55-60. [Bibliogr. de 5 titres.]
255 LOUTSCH, Henri: A propos d’une observation d’hypoglycémie pancréatique. – 1956, N° 3, 63-66. [Bibliogr. de 4 titres.]
256 HUART, François d’: Le flirt appendiculo – diverticulaire. A propos d’une observation personnelle. – 1960, N° 1, 7-15. [Bibliogr. de 31 titres.]
257 HUART, François d’: Les péritonites périodiques. – 1960, N° 3, 265-274. 1 fig. [Bibliogr. de 13 titres.]
258 HUART, François d’: Les hernies hiatales. A propos de 10 cas opérés. – 1961, NI° 1, 171-192.
259 HERTZ, Simon: Sur un cas de migraine grave associée à une lésion cholédocienne guéri par la chirurgie. – 1961, N° 3.
260 HUART, François d’: Le syndrome de l’anse stagnante. Contribution à l’étude des avitaminoses B 12 d’origine intestinale. 1961, N° 3. [Bibliogr. de 27 titres.]
261 LOUTSCH, Henri, Le rôle des névromes du moignon cystique dans les séquelles de la cholécystectomie. – 1961, N° 3. [Bibliogr. de 15 titres.]
262 NICKELS, Jean: Komplikationen des Meckel’schen Divertikels. – 1961, N° 3.
263 SCHWACHTGEN, Fernand: De l’intérêt chirurgical de certains pancréas aberrants. A l’occasion d’un cas de pancréatite canaliculaire aiguë, survenue dans un pancréas aberrant, siégeant dans la région pyloroduodénale. – 1961, N° 3.
264 HARF, [Carlos]: Communication à la Société française d’Allergie [au sujet de deux cas d’allergies hormonales]. – Décembre 1957, [N° 3], 93-94. [Bibliogr. de 7 titres.]
265 EICHHORN, Alfred: Les allergies en dermatologie. – 1960, No 2, 169-182. 1 fig. [Bibliogr. de 10 titres.]
f) Appareil respiratoire
(v. a. les Nos 148, 181, 182, 185-187, 189, 190, 281, 295, 298, 352, 354, 360, 368, 369, 540- 542.)
266 BIVORT, Hean] – B[aptiste] – A[lbert]: Note sur un cas remarquable d’emphysème pulmonaire observé en 1854 dans le service de M. Frankinet, à l’hôpital de Bavière a Liège. – 1865, 27-32.
267 FELTGEN, [Jean]: Lungenabcess in Folge von Pneumonie. – Perforation der Pleura-Pyämie. – Heilung. – 1871, 73-81.
268 MEYERS, [Jean]: Neueste operative Behandlung der eitrigen Brustfellentzündung, bestehend in der Eröffnung der Brusthöhle durch Resection eines Rippenstückes. – 1882, 13-23. 1 pl. h.-t.
269 KOCH, Paul: Corps étranger siégeant à la bifurcation de la trachée. – 1885, 12-16.
270 KOCH, Paul: Sur les corps étrangers résidant dans les premières voies respiratoires. – 1886, 23- 29. 1 fig.
271 KOCH, Paul: Sur la bronchite fibrineuse essentielle chronique. – 1895, 152-155. 3 pl. h.-t.
272 KLEIN, [Martin, Victor] THILGIS et P [aul] KOCH: Fève dans la bronche gauche d’un enfant. Appréciation des symptômes cliniques fournis par les corps étrangers des premières voies aériennes. – 1897, 91-103. [Bibliogr. dans le texte.]
273 HARP, Carlos: Asthme des fumeurs et chimie de la cigarette. – 1956, N° 1, 61-68.
274 LOUTSCH, Henri: Aspects chirurgicaux de l’emphysème pulmonaire bulleux. – 1959, N° 1, 53-66. 10 fig.
275 HOSTERT, Arsène, Madame CLAUDE et Mathias DEMOULLIN: La bronchoscopie et la bronchographie sous anesthésie générale. – 1960, N° 1, 19-24, 8 fig.
276 SCHAUS, Raymond: Emphysème médiastinal spontané. A propos d’une observation personnelle. – 1960, N° 3, 311-313. [Bibliogr. de 7 titres.]
(v. a. les Nos 153, 264, 339, 348, 367, 427, 440, 471, 473, 474, 573, 628.)
277 SCHMIT, [Pierre]: Sur quelques formes du goître. – 1865, 33-39.
278 KOCH, Paul: Gas intéressant de goître kystique présenté à la Société des Sciences médicales de Luxembourg. – 1882, 83-87.
279 MAILLIET, Edm [ond]: Morbus Cushing und Interrenalismus. – Août 1938, 73-76. 1 fig.
280 PRIM, Jos[eph]: Zur Bestrahlung des FaIles S. von Morbus Cushing. – Août 1938, 79-80.
281 HIPPERT, Frédéric: Un curieux syndrome polyviscéral. – Juin 1950, 43-45.
282 LOUTSCH, Henri: Le traitement préopératoire des hyperthyroïdies. – Décembre 1950, 1-8.
283 DAHL-IVERSEN, E.: Problèmes chirurgicaux des surrénales. Conférence… – Mai 1955, 7-16. 4 fig.
284 ABEL: Les insuffisances surrénales et leur traitement. – 1956, N° 2, 7-23.
285 FAIVRE, Gabriel: Les données actuelles du traitement médical de l’hyperthyroïdie. – 1956, N° 2, 27-33.
286 KISSEL, P.: Les syndromes neuroendocriniens. – 1956, N° 2, 51-56.
287 GENNES, L. de, M[arcel] LEMMER, H. BRICAIRE et B. Mathieu de FOSSEY: L’épreuve à la Desoxy – corticosterone dans le diagnostic des syndromes polyuro-polydipsiques. – Juin 1958, 35-42.
288 LEMMER, Marcel: A propos d’un cas <<d’agénésie ovarienne>> (Syndrome de Turner-Albright). (Turnérienne de 44 ans, génétiquement femelle, dépistée à l’occa-sion d’un goître). – Novembre 1958, 15-27. ill. [Bibliogr. de 16 titres.]
289 LEMMER, Marcel: Les comas endocriniens. I. Les comas hypopituitariens. – 1961, N° 3.
h) Maladies provoquees par des agents physiques
290 FABER, Jean: Sur un cas de brûlures des os du crâne et du cerveau par le courant électrique. – 1921, 1-16. 3 fig. [Bibliogr. de 26 titres.]
291 FELTEN, [Pierre]: Exposé sur <<le traitement des brûlures par arme atomique>>… 1956, N° I, 51-58.
292 GENAUD: Le problème des irradiés en cas de pertes massives. – Novembre 1958, 49-57.
(v. a. les Nos 28, 197, 201, 212, 214, 220, 223, 234-239, 244, 246, 251, 252, 256, 258-263, 268, 274, 282, 283, 323, 329, 332, 345, 346, 348, 413, 433-435, 437, 439, 456, 468, 500, 506, 519, 526.)
293 BIVORT, J[ean] – B[aptiste]-Al-bert]: Plaie de l’artère radiale. – Inflammation et anévrysme traumatique consécutifs. – Ièsucces de la compression digitale. – Tentative inutile de ligature d’une artère dans une plaie enflammée. – Ligature de l’artère radiale au lieu d’élection. – Guérison. Mémoire. – 1864, 33-36.
294 FELTGEN, [Jean]: Rapport sur le mémoire de M. le Dr Bivort, intitulé: Plaie de l’artère radiale, etc. – 1864, 86-89.
295 SCHMIT, [Pierre]: L’amputation offre-t-elle encore quelque chance de succès dans les tumeurs blanches en voie de suppuration et de désorganisation, alors que le malade présente, en apparence, les principaux symptômes de la phtysie pulmonaire? – 1864, 37-39.
296 SCHMIT, [Pierre]: Amputation partielle du pied, pour cause traumatique, suivie de gangrène, de phlébite et de pyémie grave. Guérison. – 1864, 40-42.
297 SCHMIT, [Pierre]: Lésions graves et nombreuses. – Guérison remarquable. – 1864, 42-45.
298 SCHMIT, [Pierre]: Souvenirs de ma pratique. (Calcul pulmonaire. Calcul formé dans le foyer d’une carie. Calculs biliaires. Corps étrangers dans les voies respiratoires. Aiguille avalée par la bouche et extradite 1/2 heure après à l’épigastre. Polypes utérins.) – 1867, 121-129.
299 NIEDERKORN, J[ean-Baptiste]: Beiträge zur conservativen Chirurgie. – 1869, 157-168.
300 FELTGEN, [Jean]: Zur Casuistik und Methode des Bruchschnittes. – 1871, 45-71.
301 AUBERT, [Pierre-Francois]: Du pansement de Lister. – 1877, 47-56.
302 NIEDERKORN, [Jean-Baptiste]: Ein Fall schwerer Verwundungen und Heilung derselben. – 1879, 87-93.
303 METZLER, N[icolas]: Zur Casuistik des antiseptischen Verbandes. – 1879, 105-113.
304 LEHNERTS, J[ ean-Pierre] : Plaie pénétrante de la poitrine avec issue du poumon droit. Guérison. – 1882, 9-12.
305 MEYERS, J[ean]: Zur Behandlung der eingeklemmten Unterleibsbrüche. Subcutane Taxis. – 1882, 24-36.
306 MULLER, Franz, Adolphe CARY et Paul KOCH: Plaie pénétrante du cou par tentative de suicide. – 1893, 83-86. 2 fig.
307 LECLERE, [Prosper]: De la greffe animale. Un cas de grave brûlure du IIIe degré, guéri d’après la méthode de Thiersch. – 1895, 116-119, 1 photogr. h.-t.
308 LECLERE, P[rosper]: Ein Fall von complicierter Schädelfractur mit Knochendepression und konsecutiver vollständiger Paraphlegie. Trepanation. Heilung. – 1897, 115-119.
309 KROMBACH, Wilh[elm]: Über eine Haematocele in der rechten Schultergegend. – 1899, 45-52, 2 fig.
310 DELVAUX, Fr [ançois]: Die Technik der Radikaloperation der Leistenbrüche. Mit XVIII Figuren im Text. – 1909, 1-253. [Bibliogr. marginale.]
311 DELVAUX, Fr[ançois]: Der gebrochene Hautschnitt bei Schenkelhemien. – 1909, 255-258. 1 fig. [Bibliogr. de 3 titres.]
312 PAULY, [Norbert]: Radikaloperationen von Leistenhernien. – 1917, 75-78. fig.
313 FABER, Jean: La réparation immédiate des grandes pertes de substance de la main. – Fe-vrier 1940, 21-27. 4 fig. [Bibliogr. de 2 titres.]
314 HARF, CIarlos] M.: Expériences d’anesthésie aux Etats-Unis d’Amérique. – Mai 1948, 66-69.
315 HERBERT, J. J.: Résultats de la chirurgie restauratrice de la hanche dans le rhumatisme. – Mars 1954, 17-25. [Bibliogr. de 5 titres.]
316 HEINTZ, Norbert: Les indications de l’opération de Judet. – Mars 1954, 27-35.
317 RICHARD, André et Norbert HEINTZ: Les têtes humérales en acrylique. – Mars 1954, 39-45. 4 fig. [Bibliogr. de 2 titres.]
318 KNAFF, Marc, Yvon RONDEAU und Michael V. KEERI-SZANTO: Penthotal-Numorphan – N2O Kombinationsnarkose. – 1961, N° 1, 157-160.
319 NICKELS, Jean: Considérations sur six traumatismes exceptionnels. – 1961, N° 3. (Bibliogr. de 36 titres.]
3. Os – Articulations – Muscles
(v. a. les Nos 152, 315-317, 317, 362, 434, 628, 631.)
320 WACQUANT, [Théodore – Willibrord] de: Description d’un appareil fort simple, destié à maintenir la réduction du pied hot chez les enfants en bas-âge. 1864, 46-47.
321 LAYEN, [Jean-Baptiste]: Etude statistique sur les infirmités et le défaut de taille considérés comme cause d’exemption du service militaire dans le Grand-Duché de Luxembourg. – 1870, 1-109. 23 tabl., 17 pl. [Bibliogr. marginale.]
322 LEHNERTS, [ Jean-Pierre ] : Observation d’une épidemie de rhumatisme articulaire general aigu pendant l’hiver 1881-1882. – 1885, 1-6.
323 METZLER, P[ierre]: Zur Casuistik der Gelenkresectionen. – 1886, 125-137.
324 WEBER, Aug[uste]: Beiträge zur Therapie bei engem Becken. – 1886, 179-184.
325 FABER, August[e]: Ein Fall von centralem Osteosarcom des Vorderarmknochen. – 1890, 199- 202.
326 KNAFF, [Edmond]: Ein Fall von spontaner Abstossung und Heilung eines Fusses nach Gangrän. – 1897, 137-141. 3 fig. h.-t.
327 PUENDEL, [Léon]: Ein Fall von isolirter Fussluxation im Talo-Tarsalgelenk. – 1897, 143-149. 328 FELTGEN, Ernest: Eine leichte Form der Luxation des Oberschenkelkopfes. – 1899, 21-23.
329 KNAFF, [Edmond]: Incomplete Luxation der Tibia nach aussen. Einrichtung. – Heilung. 1901, 159-162.
330 KNAFF, [Edmond]: Ein Fall von Ellbogengelenkbruch mit Röntgenstrahlen untersucht. – 1901, 163-168. 1 fig., 1 illustr. [Bibliogr. de 1 titre.]
331 HAMANT, A.: Ostéoarthrites chroniques non tuberculeuses de la hanche. Conférence faite le 27 novembre 1938… – Mai 1939, 33-37.
332 FABER, Jean: La réduction non sanglante de la luxation du sémilunaire. – Mai 1939, 44-47. 4 fig.
333 GRABER-DUVERNAY, Jacques : Traitement actuel des polyarthrites chroniques. – Mai 1948, 39-46. [Bibliogr. de 5 titres.]
334 THYES, Aug [uste]: La gymnastique orthopédique dans le traitement des déformations de la colonne vertébrale. – Mai 1948, 55-60.
335 GRABER-DUVERNAY, Jacques et Guy VAN MOORLEGHEM: Les sels de l’acide morrhuique dans le traitement des polyarthrites chroniques. – Juin 1949, 77-81.
336 GRABER-DINERNAY, Jacques et Guy VAN MOORLEGHEM : L’iode et le soufre retard dans le traitement du rhumatisme chronique dégénératif (et plus particulièrement de la Coxarthrose). – Juin 1950, 51-53.
337 DEMOULLIN, M[athias]: Über Recklinghausensche Knochenkrankheit. – Février 1953, 93- 107. [Bibliogr. de 30 litres.]
338 DEMOULLIN, M[athias]: Ostéopathia condensans disseminata. – 1956, N° 1, 71-76. 3 fig. [Bibliogr. de 32 titres.]
339 LOUYOT, P.: Glandes endocrines et rhumatismes. – 1936, N° 2, 83-93.
340 FRANCON, François: Erreurs et préjugés en rhumatologie. – 1956, N° 3, 7-29.
341 MICHOTTE, L. J.: Etat actuel de la thérapeutique médicale de la polyarthrite chronique évolutive. – Décembre 1957, [N° 3], 21- 33. 6 tabl.
342 FRANCON, François et Madame RAMEAUX-VAREILLE: Spondylarthrite ankylosante chez deux frères. – 1959, N° 3, 265-271. 1 tabl. [Bibliogr. de 6 titres.]
343 SCHAACK, Robert: Luxation congénitale de la hanche. La prévention est-elle possible? – 1960, N° 3, 315-317. [Bibliogr. de 1 titre.]
344 FRANCON, François: Le déclin de la maladie de Bouillaud. – 1960, N° 3, 319-323. [Bibliogr. de 9 titres.]
345 SCHAACK, Robert: L’ostéotomie de direction dans la coxarthrose. – 1961, N° 3.
(v. a. les Nos 325, 387, 388, 468, 469, 475.)
346 NIEDERKORN, [Jean-Baptiste] : Einiges über bösartige Geschwülste. – 1873, 49-56.
347 KOCH, Paul: Contribution à l’étude du cancer laryngien. – 1882, 59-63.
348 KOCH, Paul: Contribution à l’étude du sarcome primitif du corps thyroïde. – 1885, 7-11. [Bibliogr. d. I. t.]
349 BALDAUFF, [François-Valentin]: Über einen Fall von multiplen Sarcomen, wahrscheinlich im Anschluss an ein intracranielles Sarcorn. – 1886, 148-152.
350 ARENS, Ed[ouardl: ITher Orbitaltumor. Irrtum in der Diagnose. – 1886, 185-188.
351 FABER, Aug [uste]: Carcinosis generalis. – 1890, 169-172.
352 KOCH, Paul: Sur les tumeurs de la trachée. – 1893, 10-14.
353 KOCH, Paul: Fibrome du larynx. – 1895, 148-151. 5 fig.
354 LECLERE, P[rosper]: Carcinome de l’oesophage, de la trachée et du larynx, avec communication entre l’oesophage et la trachée. – 1897, 121-124.
355 MEDERNACH, Ed [ouard]) und Franz DEMUTH: Présentation de malades. Fin Fall von Fibroma pendulum giganteum ausgehend von der Vulva. – AotIt 1938, 98.
356 HERTZ, [Simon]: Tumeur bénigne dégénérée de l’estomac. – Février 1940, 16-20. 2 illustr.
357 FLORENTTN, Pierre: Le problème biologique du cancer. – Mai 1948, 9-22.
358 HERTZ, Simon: Y a-t-il un diagnostic précoce des cancers digestifs? – Mai 1948, 31-38.
359 HERTZ, Simon: Sur un cas de cancer de l’estomac. Communication. – Mai 1948, 95-99. 3 fig.
360 LOUTSCH, Henri: A propos du diagnostic précoce du cancer pri-mitif du poumon. – Décembre 1948, 15-19.
361 HIPPERT, Fréd [éric]: Tumeur abdominale. – Juin 1949, 55-56.
362 DELVAUX, Léon: Sur un cas de myélomatose décalcifiante diffuse. – Juin 1950, 47-49.
363 HERTZ, Simon: Sur un cas de cancer de l’intestin grêle. – Décembre 1950, 17-20. 2 illustr.
364 HUART, François d’: Quelques considérations sur le traitement des tumeurs malignes du sein. – Mars 1954, 47-51.
365 DEMOULLIN, M[athias]: La maladie de Sturge-Weber. – Mai 1955, 37-43. 3 fig. [Bibliogr. de 18 titres.]
366 DEMOULLIN, M[athias] : L’importance de l’urographie intraveineuse dans le traitement par radiothérapie du cancer inoperable du col utérin. – 1956, N° 1, 81-84. [Bibliogr. de 11 titres.]
367 FLORENTIN, Pierre: Le traitement hormonal des tumeurs. – 1956, N° 2, 35-48.
368 HOSTERT, Arsène: La lutte actuelle contre le cancer bronchique est-elle sans espoir? – 1960, IV’ 2, 153-158.
369 PERLIA, Charles-P.: Reflexion on breast cancer. – 1961, NT’ 3. [Bibliogr. de 17 titres.]
(v. a. les Nos 350, 490, 492.)
370 FONCK, G[ustave]: Drei am grauen Staare Erblindete, mit Erfolg operiert. – 1864, 48-53.
371 FONCK, , G[ustave]: Totalstaphylom des linken Auges. Operation. – Heilung. – 1864, 54-56.
372 FONCK, G[ustave]: Ein neues Staarmesser, zur Operation des rechtseitigen Staares mit der rechten Hand. – 1865, 59-60. 3 fig. h.-t.
373 ARENS, Ed[ouard] : Fin Fall von Cerebral-Amaurose des rechtes Auges. Heilung. – 1874, 195- 200.
374 ARENS, Ed [ouard]: Einige Bemerkungen über die 1873-1874 im Waisenhause zu Itzig grassirende granüläre Ophthalmie. — 1874, 201-207.
375 ARENS, Ed [ouard] : Beitrag zur Lehre der Reflexneurose des Opticus. Ein Fall von Amblyopia bedingt durch Parametritis chronica atrophicans. – 1877, 21-25.
376 ARENS, Ed[ouard]: Amaurosis alcoolica acuta. Plötzliche Erblindung durch Übergenuss alcoolischer Getranke. – 1877, 27-29.
377 ARENS, Ed[ouard]: Beitrag zur Lehre der Reflexneurose des Opticus. Ein Fall von Amblyopia fere amaurotica hysterica ex onania. – 1877, 37-45.
378 ARENS, Ed [ ouard 1 : Ein Wort über Augendiphtheritis. – 1885, 59-67.
379 ARENS, Ed[ouard]: Über Hornhautverknöcherung. – 1885, 68-70.
380 ARENS, Ed[ouard]: Augenverletzung durch Kugelschuss. Panophthalmitis. Sympathische Erkrankung des andern Auges. Entfernung des Bulbus mit der vorhandenen Kugel. Heilung des sympathisch erkrankten Auges. – 1885, 71-76.
381 ARENS, Ed[ouard]: Beitrag zur Pathogenese des grauen Staars nach Typhus. – 1885, 77-79.
382 ARENS, Ed [ouard]: Spontane Kataraktresorption im Verlaufe von Meningitis Cerebralis. – 1885, 80-82.
383 ARENS, Ed [ouard]: Studie über Glaucoma fulmimans. – 1886, 189-194.
384 ARENS, Ed [ouard]: Über Exophthalmus. – 1886, 195-196.
385 METZLER, P[ierre]: Ein Fall von akuter Retinitis albuminurica ex graviditate, geheilt durch künstliche Frühgeburt. – 1893, 15-19.
386 FABER, Ad[olphe] et [Joseph] PRIM: Traitement des affections herpétiformes de l’oeil par les rayons X. – Août 1938, 57-59.
387 ISRAEL, Charles: A propos d’un cas de Pseudo-tumeur inflammatoire de l’orbite. – Août 1938, 90-94. [Bibliogr. de 15 titres.]
388 KETTER, Al [oyse]: Tumeur primitive de l’iris. Extirpation et conservation de l’oeil. – Août 1938, 95-97.
389 LOOS, Emile: Etude clinique sur l’emploi de l’alpha-chymotrypsine dans la chirurgie de la cataracte. A propos de 40 observations personnelles. – 1961, N° 3. [Bibliogr. de 35 titres.]
6. Oto – rhino – laryngologie
(v. a. les Nos 139, 152, 182, 347, 353, 354.)
390 [KOCH, Paul]: Cas intéressant de laryngite catarrhale chronique suivie d’une hypertrophie de la corde vocale supérieure gauche. – 1874, 177-180. 3 fig. [Bibliogr. de 6 titres.]
391 KOCH, Paul: Construction d’un fantôme devant servir à s’exercer dans la laryngoscopie et dans les opérations qui se pratiquent à l’intérieur du larynx. – 1874, 181-184.
392 KOCH, Paul: Contribution à l’étude des affections laryn-giennes. – 1879, 1-86. [Bibliogr. d. 1. t.]
393 KOCH, Paul: Considérations cliniques sur la paralysie des muscles crico-arytenoidiens postérieurs. – 1882, 37-56. [Bibliogr. d. 1. t.]
394 KOCH, Paul: Plaie du larynx occasionnée par une fourche à foin. – 1882, 57-58.
395 KOCH, Paul: Paralysie respiratoire aiguë du larynx. – 1882, 64-65.
396 KOCH, Paul: Rétrécissement laryngien après la fièvre typhoïde. Considérations sur le laryngo-typhus. – 1882, 66-71
397 KOCH, Paul: Sur l’ignipuncture dans les affections des premières voies aériennes. – 1882, 72-76.
398 KOCH, Paul: Paralysie laryngienne chez une jeune enfant. Considérations cliniques sur les paralysies laryngiennes de l’enfance. – 1882, 77-82.
399 KOCH, Paul: Sur les effets du traitement mécanique des sténoses laryngiennes. – 1882, 88-95. [Bibliog. de 2 titres.]
400 KOCH, Paul: Sur la paralysie des muscles dilatateurs de la glotte. – 1885, 17-24. [Bibliogr. d. 1. t.]
401 KOCH, Paul: Contribution à l’étude des polypes fibreux du sinus maxillaire supérieur. – 1885, 17-24. [Bibliogr. d. 1. t.]
402 KOCH, P[aul]: Contribution à l’étude du laryngo-typhus. – 1886, 1-16. [Bibliogr. d. 1. t.]
403 KOCH, Paul: Affection des cartilages laryngiens pendant la convalescence de la fièvre typhoïde. Rétrécissement laryngien consécutif. Trachéotomie neuf ans plus tard. Guérison. – 1886, 17-20.
404 KOCH, Paul: Contribution à l’étude des corps étrangers des fosses nasales. – 1886, 21-22.
405 KOCH, Paul: Contribution à lti﷽﷽﷽﷽﷽﷽﷽﷽tion. 17dextra mit Ra-r’étude des polypes fibreux du sinus maxillaire supérieur. – 1886, 30-32.
406 KOCH, Paul: Contributions laryngologiques. – 1890, 119-167. 2 fig. [Bibliogr. d. 1. t.]
407 KOCH, Paul: Sur les corps étrangers du larynx. – 1893, 6-9. 2 fig. h.-t.
408 HEINS, [François]: Deux cas d’otite moyenne postgrippale. – 1893, 65-66.
409 KOCH, Paul: Anomalie rare de la luette. – 1895, 143-144.
410 KOCH, Paul: Un cas de polype sous- glottique. – 1895, 145-147. 2 fig.
411 KROMBACH, Wilh[elm]: Über einige interessante Beobachtungen und therapeutische Erfolge. Zwei Fälle von Sinusitus frontalis mit positivem Wassermann. Sinusitus frontalis dextra mit Radikaloperation. Über günstige Erfolge bei Behandlung von chronischen Mittelohreiterungen mit Heissfluftduschen. Über intravenöse Einspritzungen mit koncentrirten Neosalvarsanlösungen und ihren Erfolg bei syphilitischen Erkrankungen. Über einen Fall von Hyposodia perinealis. – 1917, 41-47. [Bibliogr. de 10 titres.]
412 KROMBACH, Guill [ aume]: Les atrésies et les occlusions du nez et du naso-pharynx. Leur influence sur la croissance du squelette et le développement de l’intelligence chez l’enfant. – 1921, 59-65. [Bibliogr. de 11 titres.]
413 WILLEMS, Aloyse: Méthodes personnelles de plastique laryngée par greffes de Thiersch appliquées aux laryngectomies partielles et aux pharyngo-laryngectomies. – Mai 1955, 45-53. 11 fig. [Bibliogr. de 11 titres.]
414 WILLEMS, Aloyse: Méthodes personnelles de plastique laryngée dans les laryngectomies et les pharyngo-laryngectomies. – 1961, N° 3.
415 NIEDERKORN, J [ ean-Baptiste ] : Douleur vive provoquée par l’éruption de la dent de sagesse et simulant une névralgie, guérie par une incision gingivale cruciale. – 1864, 17.
416 BIVORT, [Jean – Baptiste – Albert]: Rapport sur les observations de M. le Dr Niederkom, lues en séance générale le 3 septembre 1863, par M. le Dr Biwort [sic.]. – 1864, 80-82.
417 SCHNEIDER, E [mest]: 1862- 1937. Deux étapes dans l’histoire dentaire au Grand-Duché. Août 1938, 39-45. 2 illustr.
418 KLEES, L [ouis] et R[obert] PHILIPPART: Vers un nouveau traitement de la carie dentaire. – Mai 1948, 75-77.
419 KLEES, Louis et Robert PHILIP(P)ART: L’infection focale odontogène. – Décembre 1948, 53-61. 4 fig.
420 BISDORF[F], Norbert: Importance de la prophylaxie dentaire. – Décembre 1948, 77-81.
421 SCHUMACHER, Ernest: Ersetzen abgebrochener Zähne auf Brükken durch Kunstharzzähne. – Juin 1950, 59-61.
422 BRABANT, H., L[ouis] KLEES et R[obert] PHILIPPART: Coalescence, fusion, gémination et concrescence dentaires. – Décembre 1950, 51-57. 20 illustr. h.-t.
423 KLEES, Louis: Quelques conclusions tirées de l’étude histologigue des rapports entre les formations organiques de l’émail et le développement des caries dentaires. – 1961, N° 3.
8. Dermatologie – Venereologie
(v. a. les Nos 192, 212, 265, 355, 440, 586.)
424 BUFFET, A [dolphe-Nicolas] : Trois cas d’Elephantiasis Arabum, observés dans le Grand-Duché – 1874, 185-194.
425 WELTER, M [ichel] : Vier Fälle von acutem Blasenausschlag aus der Influenzazeit. – 1893, 30-39. [Bibliogr. d. 1. t.]
426 FELTGEN, Ernest: Eine Hautentzündung von sehr grosser Ausdehnung. – 1899, 25-27.
427 DEMUTH, Franz: Dermatologisches zu einem Fall von Cushingscher Krankheit. – Août 1938, 77-78.
428 HURIEZ, Claude: Antibiocorticothérapie de l’eczéma. – 1961, N° 2, 227-232. 3 tabl.
(v. a. le N° 411.)
429 ORGANISATION mondiale de la Santé. Une seule cure de pénicilline peut-elle guérir la syphilis? Résumé des entretiens internationaux de Paris. – Décembre 1950, 89-90.
(v. a. les Nos 197, 578, 629.)
430 NIEDERKORN, [Jean-Baptiste]: Hydatides logées dans les reins et expulsées avec l’urine. – 1864, 18-19.
431 BIVORT, [Jean-Baptiste-Albert]: Rapport sur les observations de M. le Dr Niederkorn, lues en séance générale le 3 septembre 1863. – 1864, 80-82.
432 FELTGEN, [Jean]: Ein Fall von vielfach complizirter Erkrankung der Hamrtöhre. – 1865, 40-58.
433 MEYERS, [Jean]: Ein Nierenstein als Ursache eines geschwulstähnlichen, perinephritischen Abscesses. Operation (Nephrotomie). – 1886, 138-147.
434 METZLER, N[icolas]: Kurze Mittheilung einiger nicht uninteressanter Krankheitsfälle. [Blaschenscheidenfistel. Osteomyelitis. Blasenstein. Schwere Verletzung.] – 1886, 153-168.
435 WEBER, Aug [uste]: Eine neue Methode der Vereinigung der Blasenwunde nach Sectio alta. – 1886, 169-178. 1 pl. h.-t.
436 HEINS, François: Néphrite aiguë avec urémie convulsive. Guérison rapide après une saignée. – 1893, 70-73.
437 WACQUANT, [Théodore-Willibrord] de: Innocuité et facilité d’exécution de la ponction hypogastrique de la vessie avec sonde à demeure. – 1895, 114-115.
438 KROMBACH, Wilh [elm]: Über einen günstig verlaufenen Fall von subcutaner Ruptur der Harnröhre in der pars membranacea, mit nachfolgender Harnfiltration und Septikämie. – 1899, 33-36.
439 PAULY, [Norbert]: Prostatektomie in zwei Zeiten und in Lokalanästhesie. – 1917, 79-81.
440 DEMUTH, Franz: Die klinische Bedeutung der Porphyrie. – Août 1938, 60-63.
441 HIPPERT, Fréd[éric]: Un cas de néphrose lipoïdique rebelle au traitement classique. – Mai 1948, 47-48.
442 THOMA, Joseph: Corps étrangers flottant dans la vessie. – Décembre 1948, 49-51. [Bibliogr. de 3 titres.]
443 DENNEWALD, Fernand et Simon HERTZ: Sur un cas d’urémie grave par insuffisance surrénalienne. – Mai 1955, 29-34.
444 SCHAUS, Raymond: Le diagnostic des infections urinaires à l’aide de la réaction de Griess. – 1956, N° 3, 83-89. [Bibliogr. de 19 titres.]
445 KUTTER, Dolphe: Perturbations médicamenteuses de la recherche de l’urobilinogène dans l’urine. – 1959, N° 2, 201-204. [Bibliogr. de 4 titres.]
446 NICKELS, Leon et Mathias DEMOULLIN: Calixdivertikel der Nieren. – 1959, N° 3, 275-283. 4 fig. [ Bibliogr. de 19 titres.]
447 KUTTER, Dolphe: Inhibition de la glucose-oxydase par des urines à colibacille. – 1960, N° 3, 259- 262. [Bibliogr. de 4 titres.]
(v. a. le N° 206.)
448 SCHAUS, Raymond: Faits et idées en gérontologie. – 1956, N° 1, 37-46.
11. Gynecologie et obstetrique
(v. a. les Nos 83, 171, 233, 240, 288, 298, 324, 355, 364, 366, 369, 375, 385, 562, 642.)
449 BIVORT, [Jean-Baptiste-Albert]: Note sur un nouveau mode de tamponnement pour arrêter les hémorrhagies dans les cavités. – 1864, 57-61.
450 FELTGEN, [Jean]: Rapport sur un mémoire présenté… par M. le Dr Bivort, s’intitulant: Note sur un nouveau mode de tamponnement pour arrêter les hémorrhagies dans les cavités. – 1864, 90-92.
451 FELTGEN, [Jean]: Ein Fall von Eclampsia parturientium mit glücklichem Ausgange. – 1865, 61-69.
452 BUFFET, Ad [olphe-Nicolas]: Atrésie congénitale de l’hymen avec hématocolpos, hématomêtre et hématosalpinx. – 1877, 13-19.
453 FELTGEN, [Jean]: Haematocele ante-uterina. – 1882, 116-125.
454 GRECHEN, M[athias]: Beiträge zur operativen Gynäkologie. – 1885, 28-58. [Bibliogr. d. 1. t.]
455 RAZEN, Fr [ançois]: Über das Hydramnion. – 1885, 83-90. [Bibliogr. de 10 titres.]
456 GRECHEN, Mathias: Chirurgisch-gynakologische Mittheilungen. [Acht FäIle von Laparotomie. – Über Dysmenorrhoea membra-nacea.] – 1886, 58-112. [Bibliogr. d. 1. t.]
457 KLEINWACHTER, Ludwig: Zur Behandlung des Wochenbettes. – 1890, 203-207. [Bibliogr. de 2 titres.]
458 LECLERE, [Prosper]: Einiges über Puerpuralfieber [sic]. – 1890, 209-220.
459 RAZEN, Fr[ancois]: Mittheilun-gen aus der Praxis. [Blasenmole.] – 1890, 221-224. 460 RAZEN, Fr[ançois]: Hochgradig verengtes, namentlich in der Richtung der Conjugata vera verjüngtes Becken. – 1890, 225- 231.
461 HEINS, [François]: Délivrance artificielle pour adhérence complète du placenta. – 1893, 67-69.
462 LECLERE, [Prosper]: Zur Casuistik der Haematocele retouterina. – 1893, 87-91.
463 FELTGEN, Ernest: Eine Blasenmole. – 1898, 39-42. 1 fig. h.-t. dans le volume de 1899.
464 PÜNDEL, Leo: Ein Fall von Doppel-Inversion des prolabirten Uterus vor die invertirte Scheibe [sic] wahrend der Nachgeburtsperiode. – 1898, 49-57. 4 fig.
465 DELVAUX, Fr[ançois] et C[onslant] KNEBGEN: 664 hystérectomies abdominales pratiquées la clinique St Joseph à Luxembourg au cours des vingt dernières années (1917 – 1937). – Août 1938, 52-56.
466 PRIM, Jos[eph]: Präliminäre Bestrahlung aus vitaler Indikation. Août 1938, 64-66.
467 REILES, M[athias]: L’épreuve de l’insufflation dans la prophylaxie de la rétention placentaire partielle. – Juin 1949, 43-52.
468 MILES, M[athias]: A propos de deux cas de myomectomie vaginale. Communication. – Juin 1950, 15-22.
469 DEMOULLIN, M[athias]: Avantages en radiothérapie antitumorale de l’irradiation intravaginale en gynécologie. – Juin 1950, 25-39. fig. [Bibliogr. de 49 titres.]
470 REILES, M[athias]: Malformation congénitale. Monstre double. – Décembre 1950, 27-28. 1 fig.
471 PUNDEL, J[ean-lPaul: Les oestrogènes ont-t-il [sic] une action abortive au cours de la grossesse humaine? – Juin 1951, 65-74. I Bibliogr.]
472 PUNDEL, J[ean-]Paul: Le test post-coïtal de Hühner, test de base de l’exploration étiologique de la stérilité conjugale. – Juin 1951, 75-83. [Bibliogr. de 8 ti-tres.]
473 HARTMANN, J.: L’hiperfolliculine. Que faut-il en penser? – 1956, N° 2, 59-79.
474 LEOPARDI, G. et C. PARUC-CINI-KRIEPS: Les anti-histaminiques synthétiques dans la pathologie de la menstruation. – 1956, N° 3, 69-80. [Bibliogr. de 52 titres.]
475 HIPPERT, Frédéric et Jean NICKELS: Hémorragie spontanée à localisation peu commune. – Juin 1958, 47-48.
476 KUTTER, Dolphe: A propos du diagnostic chimique de la grossesse. – 1960, N° 1, 27-30. [Bibliogr. de 11 titres.]
477 HUART, François d’: A propos d’un cas de grossesse tubaire bilatérale. – 1961, N° 2, 329-333.
478 LUKAS, Karl Hermann et Henri GLEES: Notre préparation psychologique à l’accouchement – 1961, N° I, 131-145. [Biblio-graphie de 15 titres.]
(v. a. les Nos 247, 250, 320, 497, 512, 536.)
479 PUTZ-KINN, Armande: La situation de l’enfance déficiente au Grand-Duché de Luxembourg. – Juin 1949, 85-102.
480 KOHNER, Ginette et Mathias REILES: La mortalité infantile au Grand-Duché de Luxembourg. – Décembre 1950, 59-81.
481 NEIMANN, N.: La puberté et ses maladies. – 1956, N° 2, 95-103.
482 MOLITOR, L[eon]: La vaccination contre la poliomyelite. – 1956, N° 3, 33-38. [Bibliogr. de 8 titres.] 483 LA VACCINATION contre la poliomyélite. – 1957, N° 1, 7-11.
484 HIPPERT, Frédéric: Notes pratiques sur le diagnostic des paralysies poliomyélitiques. – 1957, N° 1, 15–22.
485 THYES, Aug[uste]: Le traitement des lésions poliomyélitiques de l’appareil moteur. (Aperçu général. – La rééducation fonctionnelle.). – 1957, N° 1, 25-33. [Bibliogr. de 4 titres.]
486 FABER, Robert P. et Roger FROMES: Le traitement moderne de la poliomyélite. – 1957, N° 1, 37-43.
487 OST, Eugène: Le coli pathogène. – 1959, N° 2, 191-198. [Bibliogr. de 13 titres.]
13. Neurologie – Psychiatrie Medecine psychosomatique
(v. a. les Nos 74, 78, 191, 204, 209, 210, 232, 259, 286, 308, 365, 373, 375, 377, 382, 478, 482, 483-486, 626, 640).)
488 FELTGEN, [Jean]: 17ber Aetiologie und Wesen der Chorea. – 1867, 88-111.
489 FELTGEN, [Jean]: Über Aetiologie und Wesen der Chorea. Nachträgliches. – 1869, 101-111.
490 ARENS, Ed[ouard]: Abcessus Cerebri in regione Ganglii Gasserii. Diagnose durch Obduction bestätigt. – 1877, 31-35.
491 BUFFET, Ad [olphe-Nicolas]: Zur Lehre von den Localisationen im Grosshirn. – 1886, 33-57, 7 fig. h.-t.
492 ARENS, Ed [ouard]: Neurosismus in Bezug auf Hyperaesthesia Retinae. – 1886, 197-209.
493 FELTGEN, Ernest: Ein Fall von Gehirnverletzung mit Gehirnverlust ohne Beeinträchtigung der psychischen Thätigkeiten. – 1898, 47-48.
494 PAULY, [Norbert]: Trigeminusneuralgie und ihre Behandlung mit Alkoholinjektion. – 1917, 67-70.
495 BASTIAN, Ph[ilippe]: Ein kleiner Beitrag zur Kenntnis der Wirkung des Neosalvarsans auf luetische Erkrankungen des Nervensystems. – 1921, 73-75.
496 NOESEN, Roger: Le radio-diagnostic lipiodolé dans le syndrome de compression médullaire. Communication. – Mai 1948, 89- 93. 2 fig.
497 KLOTZ, H.-P.: Les composantes étiologiques de la spasmophilie de l’adulte, maladie constitutionnelle et familiale. – Décembre 1948, 7-13. [Bibliogr. de 1 titre.]
498 COSSA, Paul: Classification actuelle des épilepsies. – Juillet 1952, 25-29.
499 PHILIPPIDES, D.: A propos de l’artériographie cérébrale. – Juillet 1952, 31-36. 8 fig. h.-t.
500 PHILLIPPIDES, D. et B. MON-TRIEUL: Traitement chirurgical des lombo-sciatiques rebelles (d’après 300 cas opérés dont 234 hemies discales). – Juinet 1952, 39-45.
501 MISCHO, Léon: Possibilités et limites de l’électro-encephalographie. Ses indications pratiques. – Juillet 1952, 85-99. 2 fig.
502 SHAMMAS-KNAFF, Jeanny: Quelques notes sur la pratique neuro-psychiatrique en Irak. – Mars 1954, 77-78.
503 STUMPER, Ernest: Instincts, pulsions et psychoses. – Mai 1955, 19-27. [Bibliogr. de 7 titres.]
504 SHAMMAS, Jules et Jeanny SHAMMAS-KNAFF: Polynévrite sélectant la branche ophtalmique du trijumeau. – Mai 1955, 59-60.
505 STUMPER, E[mestl: Conférence faite le 15 octobre 1955 a l’occasion du Centenaire de la Maison de Santé à Ettelbruck. – 1956, N° 1, 7-20.
506 HEINTZ, Norbert: Le traitement de la paraplégie. – 1956, N° 1, 89-94.
507 HASTERT, F[emand] et P. DA-NILLON: Traitement par la réserpine de 100 malades mentaux et étude d’une méthode d’application de nature à éliminer les effets secondaires. – Décembre 1957, [N° 3], 51-63. [Bibliogr. de 15 titres.]
508 FELTEN, Pierre et Raymond SCHAUS: A propos d’un cas de méningite lymphocytaire aiguë bénigne. – Novembre 1958, 9-12.
509 BETZ, Arsène: A propos de deux cas de méningite à Listeria monocytogènes au Luxembourg. – 1959, N° 1, 7-11. [Bibliogr. de 13 titres.]
510 MULLER, Georges: Les épilepsies. Quelques aspects médicaux et sociaux. – 1959, N° 1, 17-35. 5 fig. [Bibliogr. de 21 titres.]
511 THIEBAUT, François: Conception actuelle de l’épilepsie. – 1960, N° 3, 247-257.
512 HASTERT, Fernand: Orientation générale de la neuro-psychiatrie infantile. – 1961, N° 1, 95-105. [Bibliogr. de 7 titres.]
513 MOSINGER, Michel, Henri FIORENTINI et Guy DE BISSCHOP: Etudes des critères d’objectivité dans le syndrome subjectif posttraumatique crânien. – 1961, N° 1, 11-25.
514 SCHMIT, [Pierre]: Observation de névrose compliquée d’extase et de stigmates. – 1877, 1-5.
515 BUFFET, Ad[olphe-Nicolas]: A travers asiles. Notes et souvenirs d’un étudiant-psychiatre. [Andernach. Marbourg. Eisenach. Leipzig. Alt-Scherbitz.] – 1980, 1-87. 3 pl. h.-t.
516 KOCH, Paul: Quelques observations sur le mutisme hysterique. – 1893, 1-5.
517 BUFFET, Ad [olphe-Nicolas]: Réflexions sur les causes principales de la folie et ses progrès dans notre pays. – 1897, 13-89. [Bibliogr. d. 1. t.]
518 NOESEN, Roger: Quelques aspects de la psychiatrie moderne. – Mai 1948, 61-65.
519 NOESEN, Roger: Actualités neuro-psychiatriques. I. Psychochirurgie. – Décembre 1950, 45-49.
520 MINKOWSKY, E.: Tour d’horizon en suivant le cheminement de la notion de schizophrénie. – Juillet 1952, 7-22.
521 STUMPER, Ernest: Quelques problèmes de psychiatrie de 1852 à 1952. – Juillet 1952, 47-68.
522 WELTER, Eloi: Au delà du Freudisme. – Juillet 1952, 71-83.
523 NOESEN, R[oger]: L’examen et le traitement du délinquant. – JuiIlet 1952, 107-112.
524 WELTER, Eloi: Von der psychoanalytischen zur psychosomatischen und anthropologischen Medizin. – Juin 1951, 27-46.
525 REICHEL, Ch[arles] et R[ogerl NOESEN: La pyrochoc-therapie. – Juillet 1952, 101-104.
526 PADOVANI, Paul: Réflexions d’un chirurgien devant la médecine psychosomatique. – 1961, N° 1, 61-72.
527 NOESEN, Roger: Hygiène mentale et activité professionnelle. – 1961, N° 1, 121-127.
528 SIVADON, Paul Daniel: L’hygiène mentale de l’étudiant. – 1961, N° 1, 107-118.
14. Hygiene – Bacteriologie Immunologie – Parasitologie
(v. a. les Nos 72, 129, 131, 165, 179, 180, 188, 430, 447, 546, 548, 549.)
529 SCHMIT, [Pierre]: De l’eau au point de vue sanitaire. – 1877, 71-81.
530 WELTER, M [ichel] : La question des eaux potables. – 1895, 1- 113. tabl.
531 KNAFF, [Edmond]: Demonstration eines Präparates von Leptus autumnalis. – 1893, 74-75. [3 fig. h.-t.]
532 SIEGEN, Charles: De la stérilisation des viandes provenant d’animaux tuberculeux. – 1898, 59-68.
533 OST, Eugène: Les tests de sensibilité. Quelques observations faites au Laboratoire de l’Etat à Luxembourg. – Mars 1954, 73-75.
534 BORDET, Paul: Les fondements de l’individualité. – 1959, N° 2, 219-225.
535 OST, Eugène: Considérations pratiques sur deux parasites intestinaux. – 1960, N° 1, 33-34.
536 BETZ, Arsène: L’élimination de virus par les matières fécales dans une institution d’enfants infectée par le virus poliomyélitique du type 1. – 1961, N° 3.
537 OST, Eugène: Le bacille pyocyanique (Pseudomonas Aeruginaosa). – 1961, N° 3.
15. Medecine du Travail
(v. a. les Nos 76, 77, 513.)
538 LECLERE, P[rosper]: Statistique sur l’état sanitaire des ouvriers faisant partie de la caisse de secours de la Société anonyme des Hauts-foumeaux et Forges de Dudelange pendant l’année 1894. – 1897, 125-136.
539 HIPPERT, Frédéric: La pratique de l’inspection médicale au moulin à scones (m. a sc.) de Dudelange. – Décembre 1948, 83-85.
540 HARPES, Jean: Introduction à l’étude de la silicose dans le Grand-Duché de Luxembourg. – Juin 1951, 59-63.
541 MOLITOR, Léon, M [ichel] MOSINGER, J[oseph] BARTHEL, H[ugues] HEYART et G. PERINET: Recherches sur les poussières de laminoir et leur capacité pathogène. Les sidéroses pulmonaires. – 1957, [NO2], 9-135. 170 fig. [Bibliogr. de 36 titres.]
542 MOLITOR, Léon et Michel MOSINGER: Les poussières en pathologie humaine et expérimentale. (Silicose et silico-an-thracose, sidérose et sidéro-sili-cose), par Léon Molitor et Michel Mosinger en collaboration avec C. Putz, J. Barthel, H. Heyart, H. Fiorentini, A. Gras, M. El Feki, C. Cartouzou, C. Souchon et G. de Bisschop. I. Plan et première partie. II. Deuxième partie (Partie expérimentale). III. Troisième partie (Pathogénie et traitement). – 1959, N° 2, 147-188; 1960, N° 1, 37- 103; N° 3, 331-363. 18 fig., 18 tabl. [Bibliogr. de 91 titres.]
543 NOESEN, Roger: Die Rehabilitation der Hirnverletzten. – 1961, N° 1, 27-31.
544 PIERQUIN, Louis et Pierre LAMBERT: La rééducation psycho- et neuromotrice. – 1961, N° 1, 33-50. [Bibliogr. de 7 titres.]
545 NOESEN, Roger, Jules BERGER et François BOURONE: La réhabilitation et le centre de Mondorf-les-Bains, – 1961, N° 1, 51- 58. 3 fig.
16. Phamiacologie – Phannacie – Pharmacognosie – Toxicologie
(v. a. les Nos 108, 181, 205, 213, 318, 428, 474, 495, 507, 525, 627, 638.)
546 NIEDERKORN, Flores Brayerae contre le Taenia 19.
547 BIVORT, [Jean-Baptiste-Albert]: Rapports sur les observations de M. le Dr Niederkorn, lues séance généralele 3 septembre 1863. – 1864, 80-82.
548 SCHMIT, [Pierre]: La racine de fougère mâle considérée comme taeniafuge. – 1864, 20-22.
549 BIVORT, [Jean-Baptiste-Albert]: Rapport sur la communication de M. le Dr Schmit, relativement au traitement du ténia par la racine de fougère mâle. – 1864, 83-85.
550 ROTHERMEL, Franz: Über Bieranalysen. – 1864, 75-79.
551 KROMBACH, Henri: Aufbewahrung von Radix filicis maris in Glycerin. – 1865, 70-71.
552 KROMBACH, Henri: Aufbewahrung des ferrum sulphuricum purum. – 1865, 72.
553 MEYER, J[ean]: Pepsinum. Abhandlung. – 1867, 138-144.
554 FELTGEN, [Jean]: De l’arséniate d’antimoine. Emploi thérapeutique, préparation chimique, dosage et formule d’administration. – 1869, 169-171.
555 MAYER: Vortrag über Desinfektionsmittel am 9. Februar 1872. (Verhandlungen des nat.-med. Vereins zu Heidelberg. Bd. VI.) – 1871, 83-100.
556 BUFFET, Ad [olphe-Nicolas]: Considérations sur l’action thérapeutique de l’hydrate de chloral, à propos de la guérison par ce médicament de deux cas de tétanos traumatique. – 1874, 117-138.
557 GUSENBURGER, H [ubert-Laurent]: Über das Auffinden von Mutterkom in andern Substanzen. – 1882, 146-150.
558 SCHOUE, P [ierre] -E [loy] : Über ein kohlensäurehaltiges Wasser mit Dreibasisch phosphorsaurem Kalk (phosphorsaurem Kalk der Knochen). – 1882, 151-154.
559 GUSENBURGER, H(ubert-Laurent): Die Untersuchungen der Schmieröle und Fette mit specieller Berücksichtigung der Mineralöle. – 1885, 97-133.
560 GUSENBURGER, H [ ubert-Laurent]: Ferrosuffat und Ozon. – 1886, 223-224.
561 HUSS, Nicolas: Verunreinigung mehrfach kohlensaurer Alkalien durch kohlensaures Zynkoxyd. – 1886, 225-229.
562 RAZEN, Fr[ançois]: Menthol gegen unstillbares Erbrechen der Schwangeren. – 1890, .
563 GUSENBURGER, H [ubert-Laurent]: Antrophore. 1 pl. h.-t. – 1893, 98-99.
564 GUSENBURGER, H [ubert-Laurent]: Die rohen Kresole als Desinfectionsmittel. – 1893, 100- 108.
565 HUSS, N[icolas]: Über eine mit Sapo kalinus bereitete Quecksilberjodidsalbe. – 1897, 169-172.
566 HUSS, N [icolas] : Trennung der Metalloxyde der Gruppen II, III und IV bei Gegenwart von Chrom, Phosphorsäure und Oxalsäure als Beitrag zur qualitativchemischen Analyse. – 1897, 173-178.
567 GUSENBURGER, H [ubert-Laurent]: Tanosal. – 1898, 71-72.
568 GUSENBURGER, H [ubert-Laurent]: Silesin und Maxeïn. – 1898, 72-75.
569 GUSENBURGER, H [ubert-Laurent]: Antibitine. – 1898, 75.
570 GUSENBURGER, ]Hubert-Lau-rent]: Zusammensetzung einiger neuerer Geheimmittel und Spezialitäten. [Pilules Pink du Dr Williams. Dormiol. Ovules. Péricols. Granulés.] – 1901, 141- 143.
571 SCHNEIDER, [Ernest]: Über das Rosten der Injektionsspritzen im Alkohol, und dessen Verhütung durch Alkali-Zusatz. – 1921, 67-71.
572 HARPES, Jean: Vieilles officines et vieux apothicaires de Luxembourg. – Mars 1954, 81-100. Nombr. illustr.
573 TIEREXPERIMENTELLE Betrachtungen über ein neues orales Antidiabetikum. – 1956, N° 1, 99- 102.
574 WINTON, Sigmund S. et E. CHESSROW: Étude clinique d’une association d’antibiotiques: tetracycline et oléandomycine (Sigmamycine). Extrait et traduit d’un rapport de ces auteurs <<A Clinical Study of Combined Chemotherapy: Tetracycline et Oleandomycin.>> publié dans <<Antibiotics Annual 1956-1957>>…. – Juin 1958, 63-67.
575 SCHAUS, R[aymond]: Les complications du traitement par le chlorothiazide. – 1959, N° 1, 109-110.
576 VAN OS, Hugo et Joseph DEMEULEMEESTER: L’utilisation clinique du phénylpropionate de nor-androsténolone. – 1959, N° 3, 287-307. 2 fig., 1 tabl. [Bibliogr. de 59 titres.]
577 MONDY, B.: La triamcinolone. – 1959, N° 3, 343-344.
578 EYSCHEN, Joseph: Considérations sur l’emploi d’émulsions de graisses intraveineuses [sic.]. – 1961, N° 1, 163-167. [Bibliogr. de 8 titres.]
579 SCHMIT, [Pierre]: Observation d’empoisonnement par l’usage de poires blettes. – 1877, 7-9.
580 KNAFF, Edm[ond]: Über einige Fälle von wahrscheinlicher Nahrungsmittelvergiftung. – 1890, 173-194.
581 BALDAUFF, François[-Valentin]: Beitrag zur Diagnose der chronischen Bleivergiftung. – 1890, 195-197.
582 KNAFF, [Edmond]: Fleischvergiftung? – 1893, 76-78.
583 FELTGEN, Ernest: Eine Vergiftung mit Potasche. – 1898, 43- 45.
584 CLASEN, Friedrich und Edmund KNAFF: Käsevergiftung? – 1917, 33-35.
585 KNAFF, Edmund und Friedrich CLASEN: Wurstvergiftung. Beob-achtung. – 1917, 37-40.
586 SHAMMAS, Jules et Jeanny SHAMMAS-KNAFF: Réaction toxique à la chloromycétine. Mai 1955, 55-56.
587 SCHWACHTGEN, Fernand: L’empoisonnement par l’E 605 ou parathion. (A l’occasion de trois cas observés au Luxembourg.) – 1956, N° 3, 41-53.
588 SCHWACHTGEN, Fernand et Eugène NITSCHKE: Au sujet d’une intoxication par l’alcool méthylique. – 1959, N° 1, 39-48. [Bibliogr. de 12 titres.]
589 HIPPERT, Frédéric: Sur un cas de fausse scarlatine. – 1960, N° 3, 305-308. [Bibliogr. de 11 titres.]
590 SCHWACHTGEN, Fernand: Brève notice concemant les intoxications par la margarine hollandaise <<Planta>>. – 1960, N° 3, 327-328.
17. Medecine veterinaire
(v. a. les Nos 107, 169, 172, 532.)
591 FISCHER, E[ugène]: Observation d’une maladie intestinale particulière chez le cheval, occasionnée par la présence d’un entozoaire. – 1864, 62-67. [Bibliogr. d. 1. t.]
592 FABER, Ch[arles]: Rapport sur le mémoire présenté par M. Eug. Fischer intitulé: Maladie intestinale particulière chez le cheval, occasionnée par la présence d’un entozoaire. – 1864, 92-96.
593 FISCHER, E[ugène]: Extraction d’un calcul vésical chez le cheval. – 1864, 68-70.
594 WIRTGEN, P[ierre]: Rapport sur le mémoire présenté par M. Eug. Fischer, intitulé: Extraction d’un calcul vésical chez le cheval. – 1864, 97-98.
595 FISCHER, E[ugène]: Note relative à la fécondité des femelles issues d’une naissance jumelle [chez l’espèce bovine]. – 1864, 70-71.
596 BIVORT, H[ippolyte]: Rapport sur le mémoire de M. Eugène Fischer, intitulé: Note relative à la fécondation [sic] des femelles issues d’une naissance jumelle. – 1865, 94-95.
597 FISCHER, E[ugène]: Empoisonnement des chevaux d’une écurie par la paille rouillée. – 1864, 72-74.
598 KROMBACH, Nicolas: Rapport sur un mémoire présenté par M. E. Fischer, … au sujet de l’empoisonnement des chevaux d’une écurie par la paille rouillée. – 1865, 91-93.
599 FISCHER, Eug[ène]: Du panaris chez le cheval. – 1865, 73-90.
600 SIEGEN, Charles: Rapport sur le mémoire de M. Eug. Fischer, … intitulé: Du panaris chez le che-val. – 1867, 159-164.
601 MEYER, J[ean]: Formules magistrales vétérinaires ordinairement employées dans le Grand-Duché de Luxembourg. – 1867, 130-137.
602 FISCHER, Eug[ène]: Observation d’un cas de pneumorrhagie essentielle chez le cheval. – 1867, 145-148.
603 NEYEN, J[ean-Auguste]: Rapport sur le mémoire de M. Eug. Fischer, intitulé: Observation d’un cas de pneumorrhagie essentielle chez le cheval. – 1867, 148-151.
604 BIVORT, [Hippolyte]: Observation d’une ovarite chronique et épizootique chez l’espèce porcine. – 1867, 152-153.
605 FISCHER, Eugène: Rapport sur l’observation d’une ovarite chronique et epizootique chez l’espèce porcine, présentée par M. Bivort. – 1867, 154-155.
606 SIEGEN, Ch[arles]: Plaie pénétrante de l’abdomen. Eventration épiploïque. Excision de l’épiploon. Guérison. – 1867, 156- 158.
607 SIEGEN, Charles: Du torticolis chez le cheval. Observation. – 1869, 172-174.
608 FISCHER, Eug[ène]: Rapport sur l’observation présentée par M. Ch. Siegen, intitulée: Du torticolis chez le cheval. – 1869, 175-176.
609 FISCHER, Eug [ène] : Observations pratiques sur un nouveau mode de traitement des exomphales chez les poulains, et en même temps rapport sur une brochure [i. e. Manuel de l’éleveur du cheval croisé en Belgique, par M. Foelen], envoyée à la Société. – 1869, 176-178.
610 SIEGEN, Ch[arles]: Hernie inguinale étranglée. – Herniotomie sous-cutanée. – 1873, 57- 64.
611 SIEGEN, Ch[arles]: Corrélation entre la rétivité des chevaux et les altérations profondes des principaux viscères de l’organisme. – 1879, 115-119.
612 SIEGEN, Ch [ arles] : Des oblitérations artérielles chez le cheval. – 1882, 140-145.
613 SIEGEN, Charles: Note sur deux tissus hétérotopiques. – 1885, 91-96.
614 SIEGEN, Charles: Contribution au diagnostic de la tuberculose bovine. – 1893, 92-96.
615 SIEGEN, Charles: La tuberculose de la chèvre. – 1893, 97.
616 SIEGEN, Ch[arles]: Les progrès de l’industrie laitière et la tuberculose du porc. – 1895, 120- 122.
617 SIEGEN, Charles: Tuberculine et tuberculose. – 1897, 157-163. [Bibliogr. de 3 titres.]
618 MACKEL, N[icolas]: Drei Fälle von Torsion des Uterus mit lethalem Ausgang. – 1897, 165- 167.
619 SIEGEN, Charles: Bacilles du règne végétal ressemblant aux bacilles de la tuberculose. – 1898, 69 [Bibliogr. de 3 titres.]
620 SIEGEN, Charles: Sclérodermie. – 1898, 70.
621 SPARTZ, L(éandre): Opération césarienne avec amputation de la matrice chez une chienne. – 1909, 301-302.
622 SPARTZ, L(éandre): Rapport sur la tuberculose bovine dans le Grand-Duché de Luxembourg. – 1921, 47-57.
623 SPARTZ, Léandre: Deux cas de tuberculose congénitale chez le veau. – Août 1938, 67-72.
624 RIES J(ean) – N(icolas): Contribution à l’étude de la paralyse pharyngée chez le cheval. – Août 1938, 81-82.
625 SCHMIT, (Nicolas-Dominique): Etude sur les actions physiologique et thérapeutique de la source therme de Mondorff. – 1869, 113-135. (Bibliogr. marginale.)
626 MARCHAL, Ch(arles): Etude sur l’action des eaux de Mondorf, dans les paralysies cérébrales ou hémiplegies. – 1873, 1-29.
627 SCHOUE, P(ierre) – E(loy): Die künstlichen Mineralwässer. – 1877, 83-90.
628 SCHUMACHER, (Auguste): L’arthritisme. L’eau de Mondorf dans les manifestatons de la goutte, du diabète, de l’obésite, de la phosphaturie, du rhumatime chronique. – 1921, 17-45. (Bibliogr. de 18. Titres.)
629 MUGLER, A.: Amélioration du test fonctionnel de la Phénol-Sulfone-Phtaléine (P. S. P.) par la cure de Vittel. – Juin 1950, 55-56.
630 JONES, Ch(arles): Voyage medical aux thermes de l’est de la France. Aperçu sur les bases d’un thermalisme efficace. – Décembre1950, 105-117.
631 GRABER-DUVERNAY, Jacques: La maladie traumatique locale. Ses rapports avec les rheumatismes chroniques. Sa prévention par la crénothérapie. – Mars 1954, 7-13.
632 JONES, Ch[arles]: Voyage médical à Ostende thermal. – Mars 1954, 103-107.
633 JONES, Ch[arles]: Voyage d’études thermales et climatiques en Italie. – Mars 1954, 109-117.
634 AMMON, R. et G. WERTH: Essais sur I’effet cholérétique des eaux de Mondorf. (Première communication sur les eaux de Mondorf.) Travail de l’Institut de chimie physiologique de l’Université de la Sarre, à Hormbourg/Sarre. (Traduction du travail original paru dans la <<Zeitschrift fur Bäder- und Klima-Heilkunde 1956>>). – 1956, N° 1, 23-33. 5 fig. [Bibliogr. de 20 titres.]
635 JONES, Charles: Voyage thermal aux Thermes de l’Auvergne (1956). – Décembre 1957, [N° 3], 37-47.
636 JONES, Charles: Voyage médicothermal aux stations balnéaires des Pyrénées (22- 29 juin 1958). – 1959, N° 1, 83-106. 2 photogr.
637 JONES, Charles: Voyages. – 1961, N° 3.
19. Medecine legale
(v. a. les Nos 587, 588, 590.)
638 FONCK, G [ustave], J[ean] – B[aptiste] – A [lbert) BIVORT, J[ean] MEYER und G[ustave] SCHOMMER: Tödtliche Phosphorvergiftung eines siebenjährigen Mädchens durch dessen Stiefmutter. Mitgetheilt von den mit der medico-legalen Untersuchung beauftragten Experten. – 1869, 136-156.
639 FONCK, G[ustave]: Mania transitoria a potu. Ein gerichtsärztliches Gutachten. – 1886, 210- 212.
640 NOESEN, Roger: Die Narkoanalyse in der psychiatrischen und gerichtsärztlichen Praxis. – Décembre 1950, 31-42.
20. Medecine sportive
(v. a. les Nos 86, 334.)
641 JONES, Ch[arles]: Le sport féminin à la lueur des données physiologiques et biologiques modernes. Conférences… – 1956, N° 2, 107-123.
642 JONES, Ch[arles]: Les reflets pathologiques de la gymnastique et des sports sur l’organisme de la femme. – 1956, N° 3, 91-109.
643 DECKER, Robert: Les expériences scolaires de Vanves. Le mi-temps pédagogique et sportif et la classe de neige. – 1959, N° 3, 319-327. [Bibliogr. de 9 titres.]
644 JONES, Charles: L’importance des facteurs exogènes dans le sport juvénile. – 1960, N. 2, 193- 200.
645 DECKER, Robert: L’aptitude physique générale des élèves de l’enseignement secondaire. – 1960, N° 3, 285-303. [Bibliogr. de 1 titre.]
21. Medecine militaire
(v. les Nos 79-81, 84, 134-138, 321.)